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‘Path to 2025’ Alzheimer’s Disease Summit: Reforms Urgently Needed to Streamline Road to Alzheimer’s Prevention and Treatment as Global Prevalence is Set to Triple
Date:11/6/2013

ent Currently Three Times Industry Average

One of the significant findings in the report is that the major bottlenecks in identifying an effective Alzheimer’s disease treatment are the high cost and risk of drug development and research, particularly large clinical trials of thousands of patients over multiple years that test a single drug. The report estimates that the total cost of bringing an effective Alzheimer’s treatment to market currently approaches $6 billion – nearly three times the industry average for drug development. (Total cost includes expenditures on an effective drug and on the failed drugs preceding it.)

The report considers the likely economic impacts of adopting a series of recommendations made by government agencies, expert panels, and other bodies to streamline how Alzheimer’s drugs are developed and tested. Among the reforms recommended are:

  • Developing reliable disease markers to predict the progression of Alzheimer’s disease in different patients and better match people with treatments likely to work for them;
  • Making clinical trials more efficient and less costly by establishing global trial-ready cohorts of eligible clinical trial participants as well as using adaptive trial designs that will enable the testing of multiple drugs, in combination, tailored for different at-risk populations;
  • Establishing data-sharing arrangements for companies to share precompetitive research results so that other scientists can learn more rapidly how to slow or stop Alzheimer’s; and
  • Promoting public-private partnerships that pool resources from governments, academia, industry, and patient advocates to co-invest in Alzheimer’s drug development and testing.

The report estimates that implementing these and other reforms to Alzheimer’s drug development would reduce the total cost of developing an effective Alzheimer’s treatment by nearly
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