Navigation Links
Vioxx Problems Known Years Before Recall
Date:11/23/2009

od and Drug Administration approval are too short and are usually not designed to uncover safety problems, Ross said.

"There is no mandate to publish the trials, so if you don't have access to the FDA records, you don't know what the drug risk is," he said. "Once it's approved, maybe or maybe not, the trial continues to be studied, and even then, there is no mandate to publish the findings."

The report, published in the Nov. 23 issue of the Archives of Internal Medicine, should be used to better understand drug safety, Ross said.

Ross's group set out to test the truth of a statement by Merck's chief executive officer before a U.S. Senate committee in November 2004 that earlier clinical trials showed no difference in the risk of heart events between patients taking Vioxx (rofecoxib) and those taking a placebo.

The researchers found 30 trials with a total of 20,152 patients, comparing the anti-inflammatory medication with placebo.

Twenty-one of those trials had been completed by the end of December 2000, and a risk of heart attack, stroke and death among patients taking Vioxx was clear and should have led to a safety warning, Ross said.

The risk for those cardiovascular events was 35 percent higher among patients taking Vioxx compared with those taking placebo. The association grew as more trials were completed, increasing to 39 percent in April 2002, when newer data was analyzed, and to 43 percent in September 2004, according to the study.

"Physicians and the public deserve to be in a position to make informed choices about risks and benefits, and the disclosure and dissemination of information about potential risk immediately after its recognition is absolutely essential. Our study provides insight into what should have been known about the risks of rofecoxib," the authors wrote. "If we are to detect harms early and protect the public's health, while ensuring the availability of new, clinic
'/>"/>

Copyright©2009 ScoutNews,LLC.
All rights reserved

Page: 1 2 3 4

Related medicine news :

1. Vioxxs Heart Risk Lingered Long After Use Ended
2. Merck Wins Appeal of First VIOXX(R) Case to go to Trial
3. The Lanier Law Firm Will Appeal Court Reversal of Jury Award to Widow in Nations 1st Vioxx Trial
4. Pennsylvania Attorney General Corbett Announces a Multi-state, $58 Million Settlement With Merck Over Deceptive Advertising Concerning the Safety of Vioxx
5. Vioxx Disclosure Emphasizes Need for New Web Resource that Answers Questions About Anti-Epileptic Medication Use
6. Key Vioxx Research Was Written by Merck, Documents Allege
7. Special Masters Appointed in Program to Resolve U.S. VIOXX(R) Product Liability Lawsuits
8. In Post-Vioxx Era, Biologics are Reviving the Arthritis Treatment Market
9. Merck Pays More Than $400 Million to Settle Federal, State Medicaid Fraud Investigation Sparked by Qui Tam Whistleblower Case Detailing Marketing Schemes for Vioxx(R), Zocor(R), Several Other Drugs
10. Vioxx Settlement Announced
11. Vioxx Settlement Puts Painkillers Back in the Spotlight
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2015)... , ... September 02, 2015 , ... ... combining both naturopathic and allopathic medicine, opens its second location this week at ... features roughly 1000 square feet of lounge space for patients to relax while ...
(Date:9/2/2015)... , ... September 02, 2015 ... ... nation’s largest and fastest-growing interim clinical staffing companies, has completed a recapitalization ... Group.         , BPOC and Heritage Group each offer extensive expertise ...
(Date:9/2/2015)... , ... September 02, 2015 , ... ... announced today. The two day international investment and business conference will be hosted ... 2015 in Beijing China. The full-weekend networking conference will feature leading EB-5 industry ...
(Date:9/2/2015)... ... September 02, 2015 , ... World Patent Marketing, a vertically ... safety invention that protects people from crime and other hostile situations. , "The ... CEO and Creative Director of World Patent Marketing. "The industry is growing at ...
(Date:9/2/2015)... ... September 02, 2015 , ... EDAC Systems, Inc., a leading ... and services to both government and commercial clients, today announced the release of ... IBM’s Datacap document capture platform. EDAC PurePAGE processes and enhances the images ...
Breaking Medicine News(10 mins):Health News:The Hydration Room Opens New Location In Laguna Beach, California 2Health News:The Hydration Room Opens New Location In Laguna Beach, California 3Health News:The Hydration Room Opens New Location In Laguna Beach, California 4Health News:Medical Solutions Completes Recapitalization with Beecken Petty O’Keefe & Company and Heritage Group 2Health News:Medical Solutions Completes Recapitalization with Beecken Petty O’Keefe & Company and Heritage Group 3Health News:Medical Solutions Completes Recapitalization with Beecken Petty O’Keefe & Company and Heritage Group 4Health News:The 2015 China Overseas Investment and Entrepreneurship Summit (COIES) Announced 2Health News:What Should You Be Watching As You Walk Alone At Night - World Patent Marketing's Hand Free Pocket Cop Invention 2Health News:What Should You Be Watching As You Walk Alone At Night - World Patent Marketing's Hand Free Pocket Cop Invention 3Health News:What Should You Be Watching As You Walk Alone At Night - World Patent Marketing's Hand Free Pocket Cop Invention 4Health News:What Should You Be Watching As You Walk Alone At Night - World Patent Marketing's Hand Free Pocket Cop Invention 5Health News:What Should You Be Watching As You Walk Alone At Night - World Patent Marketing's Hand Free Pocket Cop Invention 6Health News:What Should You Be Watching As You Walk Alone At Night - World Patent Marketing's Hand Free Pocket Cop Invention 7Health News:EDAC Systems, Inc. announces a new version of its Image Enhancement and Image Re-Sizing utility EDAC’s PurePAGE® 2Health News:EDAC Systems, Inc. announces a new version of its Image Enhancement and Image Re-Sizing utility EDAC’s PurePAGE® 3
... the University of East Anglia have found that gold ... particles they say reveal the presence of poisons far ... back to a lab. This they hope would help ... led by Professor David Russell use of gold nanoparticles ...
... health care despite the fact that health care expenditure ... the results of a multi-national survey that was concluded ... that United States had spent $6,280 per capital on ... countries. ,US patients reported more diagnostic errors, ...
... out of 800 samples sent to a lab from ... for bird flu, official sources say.//, ,The samples ... sent till March 17 from Burhanpur, Barwani, Khargone, Jhabua, Balaghat, ... shadow of bird flu that broke out in Jalgaon district ...
... New Delhi. The Delhi High Court Monday issued notice ... Delhi government on a public interest litigation seeking legal// ... through a repeal of section 377 of the Indian ... is a criminal offence and punishable with imprisonment up ...
... Women approaching menopause are likely to face depression, says a ... treatment.//, ,Depression is a substantial illness with significant morbidity ... that can be managed, reports the health portal WebMd. , ... Massachusetts General Hospital studied 460 Boston women aged 36 to ...
... it has been found that if there is Intrahepatic cholestasis ... on.// ,This case control study was performed ... result. Intrahepatic cholestasis of pregnancy (ICP) is an itchy skin ... ,The study is published in the April 2006 issue ...
Cached Medicine News:Health News:Gold Nanoparticles Are Good Detectors Biological Toxins 2Health News:Intrahepatic cholestasis during pregnancy predisposes to later liver disease 2
(Date:9/2/2015)... , Sept. 2, 2015 Unilife Corporation ... ASX: UNS), a developer, manufacturer and supplier of injectable ... third-party initiated expressions of interest, the Company,s Board of ... conduct a review of strategic alternatives to maximize shareholder ... explored and evaluated during the review process may include ...
(Date:9/2/2015)... , September 2, 2015 According ... by Product (Digital & Computed Radiography, Ultrasound, Computed & ... PACS) by Application (Oncology, Cardiology, Neurology) - Global Forecast ... to reach USD 2.8 Billion by 2020 growing at ... Br owse 240 Tables and 44 ...
(Date:9/2/2015)... Boston Scientific Corporation (NYSE: BSX ) is scheduled to ... September 17, in New York City . ... Dan Brennan , executive vice president and chief financial ... regarding the company with the host analyst beginning at approximately ... question and answer session will be available on the Investor ...
Breaking Medicine Technology:Unilife Announces Review of Strategic Alternatives 2Veterinary Imaging Market Worth USD 2.8 Billion by 2020 2Veterinary Imaging Market Worth USD 2.8 Billion by 2020 3Veterinary Imaging Market Worth USD 2.8 Billion by 2020 4Veterinary Imaging Market Worth USD 2.8 Billion by 2020 5Boston Scientific To Participate In 2015 Morgan Stanley Global Healthcare Conference 2
...
...
... At the entry-level, Philips Zymed 1810 Series ... preview, which gives the operator the flexibility ... complex arrhythmia. Choose an application beyond the ... flexibility. Select the interactive or automatic style ...
... Zymed 2010 plus Holter Software for ... application as easy to install, use ... data presentation as comprehensive as a ... superimposition, prospective paging and QuickScan, which ...
Medicine Products: