Navigation Links
Stomach Bacteria Might Trigger Rheumatoid Arthritis
Date:6/17/2010

Combination of genetics, environment caused mice to develop disease, study finds

THURSDAY, June 17 (HealthDay News) -- In early experiments with mice, scientists have found a bacteria living in the gut may trigger an immune response that can result in rheumatoid arthritis.

The gut of all mammals is populated with thousands of different types of bacteria, many of which are essential for developing a normal immune system. But some of these bacteria also appear to have a part in the development of autoimmune diseases, the researchers explained.

"This is an important, rather young, area of investigation," said lead researcher Diane Mathis, a professor of pathology at Harvard Medical School.

While these experiments in mice are still preliminary, and animal studies often fail to produce similar results in humans, the findings could lead to a new way of looking at autoimmune diseases and might even result in new ways to treat or prevent them.

"It may eventually be possible to ameliorate or protect from human autoimmune diseases, arthritis and others, by treating with probiotics, antibiotics or other inhibitors of bacterial products," Mathis said.

The report is published in the June 25 issue of Immunity.

For the study, Mathis and colleagues raised mice genetically prone to developing arthritis in a germ-free environment. These mice had fewer arthritis-causing antibodies than mice raised in a normal environment.

However, when the mice were put in a non-germ-free environment and had segmented filamentous bacteria placed in their stomachs, which is a common gut bacteria, the animals quickly started making antibodies and developed arthritis within four days, the researchers found.

"It is important to recognize that individuals do not 'catch' arthritis via bacterial infections," Mathis said. "Rather, the bacteria trigger a program to play out on a genetically susceptible background."

In this case, the bacteria cause the mice to make more of a type of white blood cell. The immune system reacts to these cells as threatening antibodies that in turn trigger rheumatoid arthritis, Mathis explained.

The research was funded by the U.S. National Institutes of Health.

The notion that bacteria in the stomach can affect the development of autoimmune diseases such as rheumatoid arthritis is not that farfetched since these bacteria have been linked to irritable bowel syndrome and other such diseases.

For example, stomach ulcers are caused by bacteria and successfully treated with antibiotics.

Dr. Nancy Klimas, a professor of medicine at the University of Miami Miller School of Medicine and a specialist in immunology, said that "this concept of the gut flora being important to human health is considered a rather radical concept, but it's been embraced more and more recently."

Klimas noted that a severe type of arthritis called reactive arthritis, formerly known as Reiter's syndrome, is caused by a genetic susceptibility and triggered by infection.

"You can cruise through your whole life with that little gene hanging out there and never ever have a health problem, but if you get certain acute infections those infections can trigger a huge inflammatory response and then you are left with this lifelong arthritis condition," she said.

In the future, changing the bacteria in the gut could prevent or treat some of these diseases, Klimas said. "This is an exciting new way of thinking, and it could certainly change the way we practice medicine."

Klimas speculated that the overuse of antibiotics may be changing the bacterial environment in the stomach and causing drastic increases in diseases.

"This raises the possibility that when you see illnesses that seem to be inflammatory or autoimmune, this flora of the gut may well be playing a role," she said.

More information

For more on arthritis, visit the U.S. National Library of Medicine.



SOURCES: Diane Mathis, Ph.D., professor, pathology, Harvard Medical School, Boston; Nancy Klimas, M.D., professor, medicine, University of Miami Miller School of Medicine; June 25, 2010, Immunity


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Brewing up a gentler java: Dark-roasted coffee contains stomach-friendly ingredient
2. Mumbani™ Fresh Face Pillow, an Anti-Aging and Anti-Wrinkle Sleep Accessory for Side and Stomach Sleepers!
3. Some People Cant Stomach the New 3-D Movies
4. Stomach Cancer on the Rise Among Young, White Adults
5. Stomach Acid Drugs Come with Dangers, Studies Show
6. Shape matters: The corkscrew twist of H. pylori enables it to set up shop in the stomach
7. Scientists Find Way to Track Flesh-Eating Bacteria
8. Bacterial phylotype alterations in irritable bowel syndrome
9. New Tests Confirm Wood Pallets Harbor Deadly Food Poisoning Bacteria
10. Bacteria make the artificial blood vessels of the future
11. Cavity-Causing Bacteria May Have Originated in Gut
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
 Stomach Bacteria Might Trigger Rheumatoid Arthritis 
(Date:3/30/2017)... DC (PRWEB) , ... March 30, 2017 , ... ... and organizations submitted a letter to President Trump expressing their support for an ... medical doctors, two Ph.D. scientists and one medical journalist, will hold a press ...
(Date:3/29/2017)... ... March 29, 2017 , ... In the United States alone, ... each year develop other types of metastatic brain tumors(3). Though most meningiomas are benign, ... efforts focus on finding more effective treatment options, the San Diego Gamma Knife ...
(Date:3/29/2017)... ... ... the main cause of hay fever in the United States, with an estimated 95 percent ... to July each year; with the worst time for sufferers being June and July. ... ) provide an effective defense against grass pollen; they are proven in independent studies to ...
(Date:3/29/2017)... ... March 30, 2017 , ... Sublime Naturals and its founder, Kathy Heshelow, are ... it has been used for thousands of years. , "The West has caught on, ... " Turmeric: How to Use it For Your Wellness. Overcome Inflammation, Enemy of the ...
(Date:3/29/2017)... (PRWEB) , ... March 29, 2017 , ... ... three Hours at a Walgreens store in Mississippi. AngioGenesis Labs, makers of HeartBoost, ... Stores in two southeastern states. Ingredients in HeartBoost, an over the counter heart ...
Breaking Medicine News(10 mins):
(Date:3/30/2017)... PHILADELPHIA , March 30, 2017  Lannett Company, ... the company voluntarily made a $25 million payment against ... $25 million payment, combined with the $75 million payment ... us approximately $5.5 million in annualized cash interest expense, ... executive officer of Lannett.  "Our business is solid and ...
(Date:3/30/2017)... Research and Markets has announced the ... & Forecast, By Type (Hemodialysis, Peritoneal Dialysis), By Product (Device, ... 2014 To 2025" report to their offering. ... The global ... 108.5 billion by 2025. Home-based dialysis ...
(Date:3/29/2017)... 29, 2017  Bodycad announced today that it ... 510(k) clearance for its Bodycad Unicompartmental Knee System, ... orthopaedic restoration. Bodycad is the first Canadian company ... implant system. Bodycad,s revolutionary Unicompartmental ... of the patient,s unique anatomical features and kinematics. ...
Breaking Medicine Technology: