Navigation Links
Severe Acne May Up Suicide Risk: Study
Date:11/12/2010

By Steven Reinberg
HealthDay Reporter

THURSDAY, Nov. 11 (HealthDay News) -- Severe acne may significantly increase suicide risk, and patients taking isotretinoin (Accutane) for the skin condition should be monitored for at least a year after treatment ends, Swedish researchers report.

"Treatment with Accutane actually entails an increased risk of suicide attempts," said lead researcher Anders Sundstrom, a pharmacoepidemiologist at the Karolinska Institute in Stockholm.

However, depression caused by the acne, rather than the drug itself, is probably the culprit, he said.

The risk of suicide is very small, Sundstrom stressed. There could be one suicide attempt among 2,300 people taking Accutane, and that assumes that the drug caused the suicide attempt, he said.

For the study, published online Nov. 12 in BMJ, Sundstrom's team collected data on 5,756 people treated for severe acne with Accutane from 1980 to 1989. The average age of the men was 22; the average age of women was 27.

Linking these patients to hospitalization and death records from 1980 to 2001, they found that 128 of the patients were hospitalized because of a suicide attempt.

Suicide attempts increased in the several years before Accutane was started, but the highest risk was seen in the six months after treatment ended, Sundstrom's group found.

It's possible that patients whose skin improved became distraught if their social life didn't benefit, the researchers speculated.

Also, Accutane takes time to work and acne can worsen before it gets better, Sundstrom said. "It takes a long time to get rid of the acne, and for the self-image to get better might take even a longer time," he said.

Acne so severe that it is treated with Accutane is not a trivial disease, said Parker Magin, a senior lecturer at the University of Newcastle in New South Wales, Australia, and co-author of an accompanying journal editorial. "It is a disease associated with significant psychiatric morbidity," Magin said.

It's impossible to say whether the drug or the skin disease is responsible for the increased suicide attempts, he said.

Magin agrees physicians must monitor patients taking Accutane for evidence of psychiatric problems. And since the risk exists before and after taking the drug, "we have to be vigilant for longer than the six months people might be on the medication," Magin said.

Patients with severe acne who do not get treated and those who are treated unsuccessfully should also be watched for psychiatric disturbances, the researchers said.

Isotretinoin, which has been used to treat severe acne since the 1980s, is also sold under the brand names Roaccutane, Amnesteem, Claravis, Clarus and Decutan.

Accutane has been linked to birth defects, and in 2005 the U.S. Food and Drug Administration approved a program requiring doctors to enroll patients who take it in a national registry to guard against serious side effects.

To register, patients must acknowledge the risks associated with the drug, including depression and suicidal feelings. Moreover, women must have a pregnancy test within seven days before filling their prescription. Women must also agree to use two methods of birth control and adhere to pregnancy testing on a monthly basis.

More information

For more information on acne, visit the U.S. National Library of Medicine.

SOURCES: Anders Sundstrom, pharmacoepidemiologist, Karolinska Institute, Stockholm, Sweden; Parker Magin, Ph.D., senior lecturer, University of Newcastle, New South Wales, Australia; Nov. 12, 2010, BMJ, online


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. A comparison of severe outcomes during the waves of pandemic (H1N1) 2009
2. Major clinical trial prompts call for change to treatment guidelines for severe malaria worldwide
3. Discovery shows promise against severe side effects
4. Severely injured should go directly to trauma center: Research
5. Johns Hopkins researchers turn off severe food allergies in mice
6. New treatment for severe aortic stenosis shown to save lives, Stanford researchers say
7. Disc Battery Ingestion May Cause Severe Injuries in Babies
8. Gene Rx May Fight Severe Blood Disorder
9. College Campuses See Rise in Cases of Severe Mental Illness
10. New surgery improves outcomes for severe flat foot deformity
11. Moldy homes a serious risk for severe asthma attacks in some
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
 Severe Acne May Up Suicide Risk: Study
(Date:10/13/2017)... ... October 13, 2017 , ... Many families have long-term ... long-term care insurance companies have a waiver for care if the client has a ... when the family pays for care, is often waived, so the benefits from their ...
(Date:10/13/2017)... York, NY (PRWEB) , ... October 13, 2017 , ... ... influential people in business to advocate for action towards gender equality at their inaugural ... views from around the globe, and reached a social audience of over 3 million. ...
(Date:10/13/2017)... ... , ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, has ... least understood books in the Holy Scriptures, Revelation. The Book of Revelation paints a ... centuries. Many have tossed it off as mere rubbish, but Yisrayl Hawkins says that ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, a leader in ... awarded a contract by the Center for Medicare and Medicaid Services (CMS). The ... enterprise use of Agile methodologies in a consistent and high value manner across ...
(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: the Christian history of ... Brink” is the creation of published author, William Nowers. Captain Nowers and his ... veteran, he spent thirty years in the Navy. Following his career as a ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... Fla. , Oct. 2, 2017  AllianceRx Walgreens ... company formed by Walgreens and pharmacy benefit manager Prime ... its new brand, which included the unveiling of new ... , as well as at a few other ... the new brand to patients, some of whom will ...
(Date:9/27/2017)... MIAMI , Sept. 27, 2017  Commended for their ... recent notable awards. Ranked as number one in the South ... ninth time in Inc. 5000 yearly list, the national specialty ... CEO, Armando Bardisa will soon be honored by ... Set to receive his award ...
(Date:9/22/2017)...  As the latest Obamacare repeal effort moves is ... (R-LA) and Lindsey Graham (R-SC) medical device ... industry is in an odd place.  The industry wants ... tax on medical device sales passed along with the ... increased visits and hospital customers with the funding to ...
Breaking Medicine Technology: