Navigation Links
Researchers home in on genetic signature of esophageal cancer
Date:5/18/2011

he effect of oncogenes.

Prior studies on EAC had shown an extra copy of a DNA sequence in the 7q21 chromosome region. However, Godfrey and colleagues believe they are the first to map the region with fine enough resolution to identify six genes within the core of the amplified region, and to compare them to patient outcomes.

They further honed in on two genes, CDK6 and CDK4, and through laboratory experiments proved that both genes are critical for the growth of esophageal cancer cells.

Amin Ismail, Ph.D., the postdoctoral scientist in Godfrey's lab who led the research, explained that the two molecules appear to do exactly the same thing, however CDK4 is located elsewhere, in the 12q13 chromosome region, and although it is less frequently amplified compared to CDK6, its high expression in EAC may be attributed to other genetic alterations.

Researchers explored the activity of CDK4 and CDK6 both independently and in combination. They paid special attention to CDK6, which also has been associated with poor survival in T-cell lymphoma and two common brain cancers, gliomas and medulloblastomas. CDK6 is a known regulator of the cell cycle, and thus researchers theorized that if they could shut down the CDK6 activity, the proliferation of cancer should also cease.

These experiments, Ismail said, led to the discovery that CDK6 is not acting completely alone, and that the combined over-expression of CDK6/4 was a more accurate marker of poor survival than the amplification of either gene alone.

Meanwhile, researchers knew that an experimental drug (known as PD-0332991) targeting CDK6/4 had been developed by Pfizer and Onyx, and was already being used in early clinical trials, showing promise against a range of cancers.

Therefore, the Wilmot research team tested PD-0332991 in the laboratory on esophageal cancer cells and discovered that, indeed, the drug halted CDK6/4 by inhibiting the entire cell-cycle process
'/>"/>

Contact: Leslie Orr
leslie_orr@urmc.rochester.edu
585-275-5774
University of Rochester Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
2. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
3. Researchers discover new way to kill pediatric brain tumors
4. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
5. Researchers create drug to keep tumor growth switched off
6. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
7. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
8. Clemson researchers develop hands-free texting application
9. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
10. Researchers chart genomic map spanning over 2 dozen cancers
11. Researchers discover second protective role for tumor-suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... 22, 2014 The Louis ... is dedicated to distribute health information technology innovation ... worldwide announced the development of six key guiding ... when receiving healthcare. These are an expansion of ... “providing care that is respectful of and responsive ...
(Date:10/22/2014)... 22, 2014 With the Affordable Care Act ... by the American Institutes for Research (AIR) finds that three ... use health insurance, but 42 percent say they are not ... before signing up for coverage. , The AIR survey found ... percent able to calculate correctly how much they owe for ...
(Date:10/22/2014)... Cheap Hosting USA is among the most distinguished review ... that iPower ( http://www.best-cheap-hosting-usa.com/go/iPower/ ) is the best cheap ... , “iPower is one of the most reliable hosting ... of useful products for new and old clients. What’s ... and a number of features which will appeal to ...
(Date:10/22/2014)... Your Body’s Way , In a world where a multi-billion-dollar ... can be difficult to choose the right weight loss method. ... it the healthy way? Set aside the fads and resist ... regularly, and choose foods with the most nutritional benefits. ... exercise more and eat less. Despite the number of advertisements ...
(Date:10/22/2014)... Lintelus, Inc., an event software provider, announced ... will be speaking on the subject of “Event Technology ... 28, at the Holiday Inn in New York City. ... as a Tech Demo at 12:45pm, to educate event ... engaging event experience. , The Annual Meetings Technology Expo ...
Breaking Medicine News(10 mins):Health News:The Sullivan Institute for Healthcare Innovation Announces Release of Guiding Principles for Patient Experience-Centered Care 2Health News:Many Americans Fail to Ask Basic Questions Before Signing Up for Health Insurance, National Survey Finds 2Health News:Many Americans Fail to Ask Basic Questions Before Signing Up for Health Insurance, National Survey Finds 3Health News:Many Americans Fail to Ask Basic Questions Before Signing Up for Health Insurance, National Survey Finds 4Health News:Best Cheap Hosting USA Has Recently Announced The Best Cheap Web Hosting Companies In 2014 2Health News:ReductionGuruMD Presents Ways to Improve Your Weight Loss Results 2Health News:Jay Cormier, Sr. Vice President of Sales for Lintelus, Speaks about Event Technology Integration at Meetings Technology Expo in NYC 2
... Cancer Center is teaming up with ENT and Allergy ... between Mount Sinai and ENT and Allergy Associates, the ... in the tri-state area, together will provide patients with ... and advanced surgical options for patients diagnosed with cancer ...
... 12 A new, free white paper,details how ... has,substantially reduced lift injuries while boosting staff satisfaction ... that provides patient transfer,and mobility assistance. Available ... is provided by the Safe Lifting Portal, (http://www.safeliftingportal.com ...
... Integrated, Inc., a,pioneer in health and condition (disease) ... ground-breaking Synergy Personal Health,Management program at DMAA,s Disease ... 16th at Caesar,s Palace in Las,Vegas. With ... need to stay,informed of the best practices, latest ...
... treatment for breast cancer, dramatically reduces symptoms of the ... standard medications for the mental illness, a new study ... National Institute of Mental Health (NIMH) who conducted the ... called protein kinase C (PKC) that regulates activities in ...
... Routine helps teens make better food choices as adults, study ... eat dinner with their families on a regular basis are ... adults, a new study shows. , These teens also go ... found. , Reporting in the Journal of the American ...
... NASHUA, N.H., Sept. 12 iCAD, Inc. (Nasdaq:,ICAD), ... the early identification of cancer, today announced that ... will be presenting at,the America,s Growth Capital 4th ... 12:00 p.m. (Eastern Daylight Time) at the,Sheraton Boston. ...
Cached Medicine News:Health News:Mount Sinai & ENT and Allergy Associates, LLP affiliate to fight cancer 2Health News:New Case Study Details How an Illinois Hospital Created a Safe Lifting Team that Dramatically Reduced Injuries, Increased Staff Satisfaction 2Health News:Health Integrated to Showcase Synergy Personal Health Management(R) at DMAA Conference 2Health News:Manic phase of bipolar disorder benefits from breast cancer medication 2Health News:Manic phase of bipolar disorder benefits from breast cancer medication 3Health News:iCAD to Present at America's Growth Capital 4th Annual Emerging Growth Conference 2
(Date:10/22/2014)... -- Investor-Edge has initiated coverage on the ... ), Progenics Pharmaceuticals Inc. (NASDAQ: PGNX ), ... Pharmaceuticals Inc. (NASDAQ: IDRA ), and Merrimack ... companies can be accessed at: http://investor-edge.com/register . ... ended at 4,419.48, up 2.40%, the Dow Jones Industrial ...
(Date:10/22/2014)... RIDGE, N.J. , Oct. 22, 2014 /PRNewswire/ ... (RMANJ), a world-renowned leader in the field of ... rapid approach to embryonic screening. The research abstract, ... Society for Reproductive Medicine (ASRM) meeting in ... screening (CCS) and single gene defect (SGD) pre-implantation ...
(Date:10/22/2014)... AVACEN Medical announced today that its AVACEN ... clearance by the U.S. Food and Drug Administration. This ... the Internet for: the temporary relief of joint ... and sprains . Logo - http://photos.prnewswire.com/prnh/20141021/153513 ... is a sophisticated medical device incorporating over 3,000 firmware ...
Breaking Medicine Technology:Market Momentum on Biotech Stocks - Amicus Therapeutics, Progenics Pharma, Threshold Pharma, Idera Pharma, and Merrimack Pharma 2Market Momentum on Biotech Stocks - Amicus Therapeutics, Progenics Pharma, Threshold Pharma, Idera Pharma, and Merrimack Pharma 3Market Momentum on Biotech Stocks - Amicus Therapeutics, Progenics Pharma, Threshold Pharma, Idera Pharma, and Merrimack Pharma 4Market Momentum on Biotech Stocks - Amicus Therapeutics, Progenics Pharma, Threshold Pharma, Idera Pharma, and Merrimack Pharma 5New IVF Research Highlights Improved Genetic Screening Approach To Help Parents Have Healthier Babies 2New IVF Research Highlights Improved Genetic Screening Approach To Help Parents Have Healthier Babies 3AVACEN Medical Announces FDA Clearance of First Medical Device with Internal Game Mode 2
... Presented in Spine, Lung, Liver and Prostate Treatment Emphasized the Benefits of ... , ... ARAY ), a global leader in the field of radiosurgery, today ... Radiotherapy Workshop, held in Brussels, Belgium on May 28 ...
... July 6 Questcor Pharmaceuticals, Inc. (NASDAQ:  QCOR) announced today ... Board of Directors. Dr. Blutt, 53, is the Founder and Chief Executive ... that is a shareholder of Questcor. Dr. Blutt is also board-certified in ... Medical College. , , , ...
Cached Medicine Technology:Presentations at the Third European Stereotactic Radiation Therapy and Whole Body Radiotherapy Workshop Highlight Clinical Outcomes and Emerging Trends 2Presentations at the Third European Stereotactic Radiation Therapy and Whole Body Radiotherapy Workshop Highlight Clinical Outcomes and Emerging Trends 3Presentations at the Third European Stereotactic Radiation Therapy and Whole Body Radiotherapy Workshop Highlight Clinical Outcomes and Emerging Trends 4Presentations at the Third European Stereotactic Radiation Therapy and Whole Body Radiotherapy Workshop Highlight Clinical Outcomes and Emerging Trends 5Mitchell J. Blutt, M.D. Appointed to Questcor Board of Directors 2Mitchell J. Blutt, M.D. Appointed to Questcor Board of Directors 3Mitchell J. Blutt, M.D. Appointed to Questcor Board of Directors 4Mitchell J. Blutt, M.D. Appointed to Questcor Board of Directors 5
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: