Navigation Links
Researchers discover mutations linked to relapse of childhood leukemia
Date:2/3/2013

After an intensive three-year hunt through the genome, medical researchers have pinpointed mutations that leads to drug resistance and relapse in the most common type of childhood cancerthe first time anyone has linked the disease's reemergence to specific genetic anomalies.

The discovery, co-lead by William L. Carroll, MD, director of NYU Langone Medical Center's Cancer Institute, is reported in a study published online February 3, 2013, in Nature Genetics.

"There has been no progress in curing children who relapse, in spite of giving them very high doses of chemotherapy and bone marrow transplants," said Dr. Carroll.

The discovery suggests how scientists may be able to thwart a dangerous form of acute lymphoblastic leukemia, a rapidly progressing blood-borne cancer that strikes about 6,000 people in the United States every year and accounts for more than one in four pediatric cancers. Eventually, such information could help doctors detect the early emergence of chemotherapy-resistant leukemia cells in patients and switch to a different treatment strategy before the disease can fully reassert itself.

In acute lymphoblastic leukemia, abbreviated ALL, the body's bone marrow produces an abnormally large number of lymphocytes, or white blood cells. Improved treatments have increased the overall cure rate to roughly 80 percent. But Dr. Carroll says the prognosis is especially dire for some 20 percent of patients who relapse.

Medical researchers have suspected that the reemergence of disease could be due to drug resistance, but previous efforts had not uncovered any definitive pathway. For the new study, led by Dr. Carroll and graduate student Julia Meyer, researchers at five U.S. institutions spent three years analyzing multiple bone marrow samples from pediatric ALL patients for more clues to the disease's progression.

With the help of the Children's Oncology Group, a multi-institutional clinical trial
'/>"/>

Contact: Christopher Rucas
Christopher.Rucas@nyumc.org
212-404-3525
NYU Langone Medical Center / New York University School of Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Moffitt Cancer Center researchers develop automated breast density test linked to cancer risk
2. Leading researchers warn of brain drain as scientists struggle to find funding
3. Researchers Identify Involuntary Tobacco Smoke Exposure in Boston Public Housing Authority Residents with Salivary Cotinine Testing from Salimetrics.
4. Researchers help confirm value of flow-diverting device for most challenging aneurysms
5. Researchers improve medical units to reduce nursing fatigue, cut costs
6. Researchers find gene that turns up effect of chemotherapy
7. Israeli researchers to participate in European Commission flagship
8. Tumor cells engineer acidity to drive cell invasion, Moffitt Cancer Center researchers say
9. Researchers say its time to treat anemia seriously
10. Rush researchers studying stem cell therapy to repair damaged knee cartilage
11. Researchers discover new mutations driving malignant melanoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... the most popular vaccine brands for children may not ... overlooking some cost factors when choosing vaccines, driving the ... according to a new study by University of Illinois ... be driven by numerous factors," says Sheldon H. Jacobson, ... computer science and of mathematics at the U. of ...
(Date:4/17/2014)... University of California, San Diego School of Medicine report ... suffered a recent major loss are more likely to ... The study is published in this month,s issue of ... Because compassionate behaviors are associated with better health and ... into ways to improve the outcomes of individuals whose ...
(Date:4/17/2014)... Children,s Hospital Pediatrician-in-Chief Jon McCullers, MD, was recently ... issue of Nature Reviews Microbiology , one ... McCullers, a world-renowned infectious disease specialist, and chair ... of Tennessee Health Science Center, analyzed the epidemiology ... and 1968 pandemics, as well as more recent ...
(Date:4/17/2014)... MAYWOOD, Il. (April 17, 2014) Doctors who ... disease called lymphangioleiomyomatosis (LAM) can face an agonizing ... progression of the disease and help relieve shortness ... lung transplants, and sirolimus can cause potentially fatal ... said pulmonologist Dr. Daniel Dilling, medical director of ...
(Date:4/17/2014)... 17, 2014-- Colic affects about one in five infants ... pediatric visits during the first several months after birth. ... was showing promise; however, the April 1, 2014 issue ... Valerie) reported on a study, "Probiotics and Infant Colic," ... reuteri for infant colic did not reduce ...
Breaking Medicine News(10 mins):Health News:Study recalculates costs of combination vaccines 2Health News:The ilk of human kindness 2Health News:Patients with rare lung disease face agonizing treatment dilemma 2Health News:Patients with rare lung disease face agonizing treatment dilemma 3Health News:New study says probiotic use for infant colic is not effective in reducing symptoms 2
... - Men are four times more likely to develop liver ... hormones androgen and estrogen. Although this gender difference has been ... estrogens prevent -- and androgens promote -- liver cancer remain ... week from the lab of Klaus Kaestner, PhD, professor of ...
... People taking blood thinners who suffer a minor head injury ... study included 87 patients taking warfarin (brand name Coumadin) who ... department. Warfarin is widely prescribed to prevent blood clots. ... CT scan, hemorrhage lesions were seen in five of the ...
... Reporter , WEDNESDAY, Jan. 18 (HealthDay News) -- New research suggests ... density scan -- a test that helps measure the strength of ... 15 years before getting another scan. However, women who show ... than that, the study authors noted. "Women who had good ...
... Why does health care need to be redesigned? First the ... yields little value for patients and society. Second it,s fixable. ... Happen are convinced of it. The contributors to the book ... transform care for their own patients within their own practices and ...
... problems in one of the body,s most complex organs ... by Wayne State University researchers. Howard Matthew ... science, recently received a $550,000 grant from the National ... liver metabolism that can be used to analyze and ...
... In a study investigating immune response in cancer, ... the University of South Florida have found that interaction ... myeloid-derived suppressor cells (MDSC) cells that play a ... the nature of MDSC-mediated suppression. By contrast, the same ...
Cached Medicine News:Health News:Gender differences in liver cancer risk explained by small changes in genome 2Health News:Some Women Can Go Longer Between Bone Checks: Study 2Health News:Some Women Can Go Longer Between Bone Checks: Study 3Health News:Sooner or later, we are all patients 2Health News:NSF grant will aid Wayne State professors' mathematical modeling of fatty liver predictors 2Health News:Study finds potential key to immune suppression in cancer 2
(Date:1/15/2014)... Jan. 15, 2014  A novel wearable injector slightly larger than ... for patients to self-inject prescription drugs in the large doses ... blood diseases, autoimmune deficiencies, and genetic disorders.  ... $220B by 2018, according to analysts.   Many of these drugs ...
(Date:1/14/2014)... , Jan. 14, 2014 InformEx, North America,s ... of high-value chemistry, will hold the 30 th edition ... Convention Center from January 21-24. (Logo: ... from top pharmaceutical, fine chemical and specialty chemical companies will ...
(Date:1/14/2014)... 14, 2014 /PRNewswire-iReach/ -- Acumed,s new SLIC Screw System ... accompanying instrumentation to place and insert the screw accurately ... tissue (e.g. ligament) repair or reconstruction as it holds ... (Photo: http://photos.prnewswire.com/prnh/20140114/MN45636 ) The ...
Breaking Medicine Technology:Enable Injections Presents A New Class of Injectors for Drug Delivery at PEPTalk, Drug Delivery Partnership Meetings 2Media Advisory: InformEx 2014 Events & Speaker Lineup for 30th Edition Conference in Miami Beach 2Acumed introduces the Scapho-Lunate Inter Carpal (SLIC) Screw System 2Acumed introduces the Scapho-Lunate Inter Carpal (SLIC) Screw System 3
... May 5, 2011 Cardiac Network, Inc. (Other OTC: CNWI.PK) ... 1-for-750 reverse stock split (the "Reverse Stock Split"). The Reverse ... and trading on May 6, 2011 (the "Effective Date"). On ... from "CNWI" to "CNWID" for approximately 20 business days, after ...
... ARAY ), a global leader in the field ... of fiscal year 2011, ended March 31, 2011. ... total revenue of $54.7 million, an increase of five percent ... of fiscal 2010. Total revenue during the third quarter of ...
Cached Medicine Technology:Cardiac Network Announces Reverse Stock Split 2Accuray Announces Results for Third Quarter of Fiscal 2011 2Accuray Announces Results for Third Quarter of Fiscal 2011 3Accuray Announces Results for Third Quarter of Fiscal 2011 4Accuray Announces Results for Third Quarter of Fiscal 2011 5Accuray Announces Results for Third Quarter of Fiscal 2011 6
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: