Navigation Links
Parkinson's Transplant Mystery Solved, Researchers Say
Date:6/30/2010

ded no medication for Parkinson's -- not everyone improved, Politis said.

And over time, the majority of transplanted patients suffered dyskinesias, leading ethics commissions around the world to end human trials in the 1990s, he said.

In the new study, using brain imaging, Politis and his colleagues found that the dopamine neurons that decay in Parkinson's disease were restored and functioning in the two patients. But they also found abnormal levels of serotonin neurons within the transplanted tissue.

The serotonin neurons were releasing dopamine, which, when coming from the wrong source, caused the jerking movements.

When patients were given a serotonin receptor agonist, a drug that prevented the serotonin neurons from firing, the involuntary movements ceased.

"Both patients responded by a sudden and almost complete resolution of the troublesome abnormal movements, suggesting that the excess serotonergic neurons had in fact been pumping out dopamine, causing the dyskinesias," Politis said.

It's possible that removing serotonin cells during the preparation of transplanted tissue in future trials will prevent side effects from developing, he added.

"We believe the first priority is to make the whole procedure more safe," Politis said. "We need to establish patients won't have anything worse happening to them after the surgery. And this study addresses that."

European and North American researchers plan a new round of human trials with fetal cells in Parkinson's disease in 2012, Politis said.

Dr. Michael S. Okun, national medical director for the National Parkinson Foundation, said the study "offers some potentially important insights into the role of serotonin in off-medication dyskinesias that may be encountered following Parkinson's disease fetal cell grafting."

"The notion that a simple drug acting on the serotonin system, buspirone, proved useful in short, four-hour testing performed in two
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3

Related medicine news :

1. Higher cancer rates found in liver transplant patients receiving cyclosporine for immunosuppression
2. Israel Penn Registry marks 3,000 consults for transplant care providers
3. The experience of arterial reconstruction in adult-to-adult living donor liver transplantation
4. Longer Antiviral Therapy Reduces Lung Transplant Complications
5. Immune system helps transplanted stem cells navigate in central nervous system
6. Lack of private insurance contribute to higher deaths among black heart transplant patients
7. Color-coded tracking method helps scientists analyze outcomes of newly transplanted tissue
8. Shortage of Transplant Organs Spurs Proposals But No Solution
9. Gene pattern may identify kidney transplant recipients who dont need lifelong anti-rejection drugs
10. Gene pattern may identify kidney transplant recipients who dont need life-long anti-rejection drugs
11. African-Americans and women are less likely to undergo bone marrow transplantation
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
 Parkinson's Transplant Mystery Solved, Researchers Say 
(Date:4/17/2014)... most popular vaccine brands for children may not be ... some cost factors when choosing vaccines, driving the market ... to a new study by University of Illinois researchers. ... driven by numerous factors," says Sheldon H. Jacobson, a ... science and of mathematics at the U. of I. ...
(Date:4/17/2014)... April issue of Experimental Biology and Medicine ... Rex Gaskins and Paul Kenis in the Institute ... the University of Illinois Urbana-Champaign describe their recent ... underlie a variety of cell functions including energy ... crucial roles in regulating normal cellular behavior, redox ...
(Date:4/17/2014)... Colo. (April 17, 2014) Two recent papers ... researcher and colleagues may help scientists develop treatments ... Yellow fever, Japanese encephalitis and other disease-causing flaviviruses. ... biochemistry and molecular genetics at the School of ... Howard Hughes Medical Institute, and colleagues recently published ...
(Date:4/17/2014)... Le Bonheur Children,s Hospital Pediatrician-in-Chief Jon McCullers, MD, ... the April issue of Nature Reviews Microbiology ... Dr. McCullers, a world-renowned infectious disease specialist, ... the University of Tennessee Health Science Center, analyzed ... 1918, 1957 and 1968 pandemics, as well as ...
(Date:4/17/2014)... 17, 2014U.S. military personnel who served in Iraq ... traumatic brain injury (TBI) were compared to military ... medical reasons. Differences in measures of overall disability, ... after injury are reported in an article in ... from Mary Ann Liebert, Inc., publishers. The article ...
Breaking Medicine News(10 mins):Health News:Study recalculates costs of combination vaccines 2Health News:Live cell imaging reveals distinct alterations of subcellular glutathione potentials 2Health News:CU researchers discover target for treating dengue fever 2Health News:Long-term effects of battle-related 'blast plus impact' concussive TBI in US military 2
... BioSciences, Inc., announced,today that it has received 510(k) ... (FDA) for Embozene(TM) Color-Advanced Microspheres which,are indicated for ... number of blood vessels in many locations) and ... sales of,Embozene(TM) Microspheres will begin immediately. , ...
... /PRNewswire-Asia-FirstCall/ -- Mindray Medical,International Limited (NYSE: MR ... worldwide, today announced that it will present at,the 27th ... January,12th-15th, 2009. , ... Mindray,s Chief,Financial Officer, Ronald Ede, Group Vice President of ...
... Ogren Group study quantifies ROI of Lumension,s integrated application whitelisting ... , ... Scottsdale, Ariz. (PRWEB) December 16, ... and IT functions have on the enterprise, Lumension Security ...
... Encounter Management Systems (TEMS) in an effort to provide more ... ... N. Chelmsford, MA (PRWEB) December 15, 2008 -- Capitalizing on ... cable from Canada, Greenland,s National Management of Health has embarked ...
... landmark "Sexual Behavior in the Human Male" report revealed ... even using the word "bisexual" -- when it was ... Kinsey and his research team at Indiana University. ... Rating Scale, commonly known as the Kinsey Scale, as ...
... Insurance LLC (Pets Best) announced today that effective December ... Insurance Company of Connecticut (AICC) in Alabama, District of ... change will strengthen Pets Best,s overall position in the ... growth of its mission to protect pets throughout the ...
Cached Medicine News:Health News:CeloNova BioSciences Receives FDA Market Approval for Embozene(TM) Color-Advanced Microspheres Embolization Platform 2Health News:CeloNova BioSciences Receives FDA Market Approval for Embozene(TM) Color-Advanced Microspheres Embolization Platform 3Health News:CeloNova BioSciences Receives FDA Market Approval for Embozene(TM) Color-Advanced Microspheres Embolization Platform 4Health News:Mindray Medical to Present at the 27th Annual J.P. Morgan Healthcare Conference 2Health News:Lumension Provides Leading e-Commerce Company Proactive Endpoint Security at a High Return 2Health News:Lumension Provides Leading e-Commerce Company Proactive Endpoint Security at a High Return 3Health News:Lumension Provides Leading e-Commerce Company Proactive Endpoint Security at a High Return 4Health News:Greenland's National Management of Health Partners with AMD Global Telemedicine Inc. and AFHCAN to Install Telemedicine Encounter Management Systems (TEMS) Across Greenland 2Health News:Indiana University researchers revisit male bisexuality 2Health News:Indiana University researchers revisit male bisexuality 3Health News:Pets Best Announces New Underwriter for Pet Insurance Policies 2Health News:Pets Best Announces New Underwriter for Pet Insurance Policies 3
(Date:1/14/2014)... 2014 The Brandeis Medical Center, led by Dr. Emmanuel ... and affordable laser tattoo removal experience with the advanced Astanza Duality ... providing high quality cosmetic services with cutting edge medical technology and ... Southern California has seen a dramatic increase in the ...
(Date:1/14/2014)... , Jan. 14, 2014 /PRNewswire-iReach/ -- Acumed,s new SLIC ... guide with accompanying instrumentation to place and insert the ... the soft tissue (e.g. ligament) repair or reconstruction as ... heals. (Photo: http://photos.prnewswire.com/prnh/20140114/MN45636 ) ...
(Date:1/14/2014)...   NuAire , a manufacturer of ergonomically designed laboratory equipment ... of Japan to sell and service ... . NuAire will utilize its network of sales professionals throughout ... to offer assistance in application use, product benefits and features, ...
Breaking Medicine Technology:Beverly Hills Physician Features Tattoo Removal with the Astanza Duality Laser, Offers $99 Special 2Acumed introduces the Scapho-Lunate Inter Carpal (SLIC) Screw System 2Acumed introduces the Scapho-Lunate Inter Carpal (SLIC) Screw System 3NuAire announces sales and service of Hitachi Koki centrifuges in North America 2
... the medical device industry gathers at Sales and Marketing Excellence 2010 ... device companies a solution to promote and sell in this highly regulated ... Maureen Shaffer ... "Sales-Friendly Compliant Content Communication: How to Score Wins for Sales, Marketing, and ...
... Georgia , May 20, 2010 , ... - Critical Care Pharmacology Course Promotes Patient ... ... than 1,300 healthcare organizations,has partnered with the American Association of Critical-Care Nurses (AACN) ...
Cached Medicine Technology:Prolifiq Offers Best Practices Solution for Selling Medical Devices in Tough Regulatory Environment 2Prolifiq Offers Best Practices Solution for Selling Medical Devices in Tough Regulatory Environment 3Elsevier/MC Strategies Partners with American Association of Critical-Care Nurses to Launch Interactive, Online Pharmacology Course 2Elsevier/MC Strategies Partners with American Association of Critical-Care Nurses to Launch Interactive, Online Pharmacology Course 3Elsevier/MC Strategies Partners with American Association of Critical-Care Nurses to Launch Interactive, Online Pharmacology Course 4Elsevier/MC Strategies Partners with American Association of Critical-Care Nurses to Launch Interactive, Online Pharmacology Course 5Elsevier/MC Strategies Partners with American Association of Critical-Care Nurses to Launch Interactive, Online Pharmacology Course 6Elsevier/MC Strategies Partners with American Association of Critical-Care Nurses to Launch Interactive, Online Pharmacology Course 7
SCD Sequential Compression System Intermittent Pneumatic Compression...
Comfor™ Cast Boot - Rocker Sole - Closed Toe...
... A new cast boot specially lasted ... a double rocker sole for easy ... around a narrow last so it ... cast boots, and with our stretchable ...
Ideal for use with thinner casting materials such as polyester or fiberglass. Conforms to any casting material....
Medicine Products: