Navigation Links
New Way to Make Stem Cells?

Chemicals can do the work previously handled by genes, researchers find

THURSDAY, Oct. 8 (HealthDay News) -- Scientists say they can use chemicals to turn adult cells into patient-specific stem cells instead of relying on potentially cancer-causing genes.

U.S. researchers used chemicals to replace two of the four genes needed to turn adult cells into induced pluripotent stem cells (iPSCs), which are similar to embryonic stem cells.

"Stem cells have the greatest potential to dramatically change and improve the way we treat diseases," study lead author Justin K. Ichida, of the Harvard Stem Cell Institute, said in a news release. "We're very excited about our findings because it means that in the near future we should be able to make limitless supplies of stem cells and possibly replacement cells for patients with diseases."

Previous research identified four genes that can transform adult stem cells into iPS cells. The genes are delivered via a retrovirus that integrates into a cell's DNA. However, the DNA from the virus remains in the cells and, over time, may activate cancer-causing genes.

In this study, the researchers substituted small chemical molecules for two of the genes.

"This discovery is exciting because it demonstrates the feasibility of using chemicals to make safer patient-specific stem cells for transplantation medicine," Ichida said.

"One of the most important things we learned from this study is that with respect to molecular pathways, there may be several ways to convert one type of cell into another. By using a non-biased chemical screening approach, we uncovered a previously unknown way to make stem cells. The big challenge over the next decade will be to figure out how to make the right cells for disease treatment. This approach will be important for achieving that goal."

The study, funded by the New York Stem Cell Foundation, is published online Oct. 8 and in the Nov. 6 print issue of the journal Cell Stem Cell.

More information

The U.S. National Institutes of Health has more about stem cells.

-- Robert Preidt

SOURCE: New York Stem Cell Foundation, news release, Oct. 8, 2009

Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. What is the suppressing effect of the PPAR-gamma ligands on stomach cancer cells?
Post Your Comments:
(Date:11/26/2015)... ... November 26, 2015 , ... Indosoft Inc., developer and distributor of ... server to improve system efficiency and reliability. , The new Q-Suite 6 platform is ... the system avoids locking itself into a specific piece of software for many key ...
(Date:11/25/2015)... ... , ... The holiday season is jam-packed with family dinners, ... attendees is of the utmost importance. Whether you are cooking at home for ... a try this holiday season. , Turkey Croquettes ,     Ingredients: , ...
(Date:11/25/2015)... ... November 25, 2015 , ... TyloHelo Inc ... and accessories. , Sauna accessories help improve the bather experience in the sauna, ... basic styles for the purist looking for simplicity in design to accessories that ...
(Date:11/25/2015)... ... November 25, 2015 , ... On November 10, 2015, Bohrer ... Court of Connecticut on behalf of a home health care worker who provided companionship ... former home health care workers employed by Humana, Inc., Humana at Home, Inc., and ...
(Date:11/25/2015)... ... 2015 , ... Lakeview Health, a Jacksonville-based drug and alcohol ... and show through pictures what a positive difference it makes. The social media ... hashtag #FacesOfGratitude on their Facebook, Twitter, and Instagram accounts. Short stories can ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... DUBLIN , November 26, 2015 ... has announced the addition of the  ... in the European Cell Surface Marker ... Emerging Opportunities"  report to their offering.  ... announced the addition of the  "2016 ...
(Date:11/25/2015)...  Amgen (NASDAQ: AMGN ) today announced the ... the United States (U.S.) Food and ... to Humira ® (adalimumab). Amgen believes this submission ... FDA and represents Amgen,s first BLA submission using the ... M.D., executive vice president of Research and Development at ...
(Date:11/25/2015)... 25, 2015 AAIPharma Services Corp./Cambridge Major ... at least $15.8  Million to expand its laboratories ... . The expansion will provide additional office ... growing demands of the pharmaceutical and biotechnology markets. ... will provide up to 40,000 square feet of ...
Breaking Medicine Technology: