Navigation Links
New Way to Make Stem Cells?
Date:10/8/2009

Chemicals can do the work previously handled by genes, researchers find

THURSDAY, Oct. 8 (HealthDay News) -- Scientists say they can use chemicals to turn adult cells into patient-specific stem cells instead of relying on potentially cancer-causing genes.

U.S. researchers used chemicals to replace two of the four genes needed to turn adult cells into induced pluripotent stem cells (iPSCs), which are similar to embryonic stem cells.

"Stem cells have the greatest potential to dramatically change and improve the way we treat diseases," study lead author Justin K. Ichida, of the Harvard Stem Cell Institute, said in a news release. "We're very excited about our findings because it means that in the near future we should be able to make limitless supplies of stem cells and possibly replacement cells for patients with diseases."

Previous research identified four genes that can transform adult stem cells into iPS cells. The genes are delivered via a retrovirus that integrates into a cell's DNA. However, the DNA from the virus remains in the cells and, over time, may activate cancer-causing genes.

In this study, the researchers substituted small chemical molecules for two of the genes.

"This discovery is exciting because it demonstrates the feasibility of using chemicals to make safer patient-specific stem cells for transplantation medicine," Ichida said.

"One of the most important things we learned from this study is that with respect to molecular pathways, there may be several ways to convert one type of cell into another. By using a non-biased chemical screening approach, we uncovered a previously unknown way to make stem cells. The big challenge over the next decade will be to figure out how to make the right cells for disease treatment. This approach will be important for achieving that goal."

The study, funded by the New York Stem Cell Foundation, is published online Oct. 8 and in the Nov. 6 print issue of the journal Cell Stem Cell.

More information

The U.S. National Institutes of Health has more about stem cells.



-- Robert Preidt



SOURCE: New York Stem Cell Foundation, news release, Oct. 8, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. What is the suppressing effect of the PPAR-gamma ligands on stomach cancer cells?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Apple ... care services, staged a mock evacuation of the facility as part of a disaster ... Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well as the ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Global Healthcare Management’s ... Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare Management’s ... The fun run is geared towards children of all ages; it is a ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the ... danger possible to save lost souls in the Philippines. “The Journey: From the Mountains ... a dedicated teacher of the Bible. She has taught all ages and currently teaches ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest and ... plans to open a flagship location in Covington, LA at 401 N. U.S. Highway ... store next to Office Depot in the Holiday Square shopping center. Its location allows ...
(Date:10/12/2017)... ... 2017 , ... Asante, a nationally recognized health system in ... existing home health joint venture through an agreement, effective October 1, 2017, to ... home health company with Asante, delivering clinically integrated care, for the past eight ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... -- NDS received FDA 510(k) clearance in May 2017 for its highly ... designed for endoscopy environments. An innovative secondary monitor solution, ZeroWire ... support the improvement of patient outcomes, procedural efficiency, and the lowering ... ... ...
(Date:10/4/2017)... 4, 2017  South Korean-based healthcare product Development Company ... "cprCUBE" on Kickstarter. The device will educate the user ... with better efficiency compared to the dated and pricey ... on efficacy of the compression for a more informed ... goal to raise $5,000. ...
(Date:10/2/2017)... 2017  Eli Lilly and Company (NYSE: ... third quarter of 2017 on Tuesday, October 24, 2017. ... day with the investment community and media to further ... call will begin at 9 a.m. Eastern time. Investors, ... webcast of the conference call through a link that ...
Breaking Medicine Technology: