Navigation Links
New Study Data: JANUVIA™ (sitagliptin) Significantly Reduced Blood Sugar Levels and Was Not Associated with Hypoglycemia in Elderly Patients with Type 2 Diabetes
Date:11/21/2008

.

Following a [14Csitagliptin oral dose, approximately 16% of the radioactivity was excreted as metabolites of sitagliptin. Six metabolites were detected at trace levels and are not expected to contribute to the plasma DPP-4 inhibitory activity of sitagliptin. In vitro studies indicated that the primary enzyme responsible for the limited metabolism of sitagliptin was CYP3A4, with contribution from CYP2C8.

Excretion

Following administration of an oral [14Csitagliptin dose to healthy subjects, approximately 100% of the administered radioactivity was eliminated in feces (13%) or urine (87%) within one week of dosing. The apparent terminal t1/2 following a 100mg oral dose of sitagliptin was approximately 12.4 hours and renal clearance was approximately 350mL/min.

Elimination of sitagliptin occurs primarily via renal excretion and involves active tubular secretion. Sitagliptin is a substrate for human organic anion transporter-3 (hOAT-3), which may be involved in the renal elimination of sitagliptin. The clinical relevance of hOAT-3 in sitagliptin transport has not been established. Sitagliptin is also a substrate of p-glycoprotein, which may also be involved in mediating the renal elimination of sitagliptin. However, cyclosporine, a p-glycoprotein inhibitor, did not reduce the renal clearance of sitagliptin.

Special Populations

Renal Insufficiency

  • single-dose, open-label study was conducted to evaluate the pharmacokinetics of JANUVIA (50mg dose) in patients with varying degrees of chronic renal insufficiency compared to normal healthy control subjects. The study included patients with renal insufficiency classified on the basis of creatinine clearance as mild (50 to <80mL/min), moderate (30 to <50mL/min), and severe (<30mL/min), as well as patients with ESRD on hemodialysis.
    '/>"/>

Source: PRWeb
Copyright©2008 Vocus, Inc.
All rights reserved  

Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33

Related medicine news :

1. STAAR Surgical Forms Team of Leading Ophthalmic Surgeons to Study the Use of Collamer(R) Material for Accommodating Intraocular Lenses
2. Landmark study defines benefits of early HIV testing and treatment for infected infants
3. Study identifies causes of bone loss in breast cancer survivors
4. New Study by BioTrends Highlights Practice Management Shifts Among Canadian Nephrologists
5. Study Suggests Need for More Aggressive Outpatient Monitoring of Patients Hearts When Cause of Stroke is Unclear
6. Rutgers researchers study cites media violence as critical risk factor for aggression
7. Brigham and Womens Researchers Partner with Vocantas to use CallAssure in Clinical Research Study
8. Analyst Available to Comment on New JUPITER Study That Shows AstraZenecas Crestor Significantly Reduces CV Risk
9. New Study Finds CO2 Ablative Fractional Resurfacing Safe And Effective For Deep Acne Scarring
10. Study investigates Gore-tex-type device to stop strokes and mini-strokes
11. The smart way to study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
 New Study Data: JANUVIA&#8482; (sitagliptin) Significantly Reduced Blood Sugar Levels and Was Not Associated with Hypoglycemia in Elderly Patients with Type 2 Diabetes 
(Date:10/31/2014)... HealthDay Reporter THURSDAY, Oct. 30, ... additional $100 million in the fight against the Ebola outbreak ... the World Bank,s total pledge to more than $500 million, ... to the three hardest-hit countries -- Guinea, Liberia and Sierra ... has increased significantly in recent weeks, but we still have ...
(Date:10/31/2014)... Oct. 30, 2014 (HealthDay News) -- Wearing masks made ... festivities that could be risky for children with asthma, ... association advises parents to be proactive about managing their ... enjoyable. Some of the steps they recommend parents ... and haunted houses are exciting adventures that can lead ...
(Date:10/31/2014)... Steven Reinberg HealthDay ... Leprosy, although quite rare, continues to appear in the United ... new cases are reported in the United States each year, ... said. That compares to about 250,000 cases that occurred worldwide ... times, leprosy is an infectious disease that causes skin sores, ...
(Date:10/31/2014)... — A new report by Milken Institute School ... George Washington University examines the challenge of maintaining ... enrolled in Covered California and who are also ... Services Program (CPSP). The CPSP, whose roots are ... ever developed for low-income pregnant women, makes enriched ...
(Date:10/30/2014)... an institutional patient registry on stereotactic body radiotherapy ... of tumors, for medically inoperable, early stage lung ... 2012, according to research presented today at the ... Symposium is sponsored by the American Society of ... Oncology (ASTRO), the International Association for the Study ...
Breaking Medicine News(10 mins):Health News:World Bank Pledges $100M More to Fight West Africa's Ebola Outbreak 2Health News: Halloween Safety Tips for Kids With Asthma 2Health News:Leprosy Still Occurs in U.S., CDC Reports 2Health News:Leprosy Still Occurs in U.S., CDC Reports 3Health News:Report examines health care challenges for pregnant women enrolled in covered California 2Health News:Sustained local control for medically inoperable, early stage lung cancer patients 2Health News:Sustained local control for medically inoperable, early stage lung cancer patients 3
... Health has awarded $10.24 million to Fred Hutchinson Cancer ... to understand and prevent breast cancer disparities in Hispanic ... nationwide to receive funding as part of the NIH ... is launching a major new effort to understand and ...
... a specific type of dopamine receptor gene respond ... without the genotype, according to new research from ... come from the first-ever placebo-controlled pharmacogenetic drug trial ... to evaluate variants of the DRD4 dopamine receptor ...
... According ... the ages of 25 and 34 report being taught to practice defensive medicine. , ... Atlanta, GA (PRWEB) May 3, 2010 -- According to ... of physicians between the ages of 25 and 34 report being taught to practice defensive medicine., ...
... ... National Lupus Awareness Month 2010 with a 115-sq-ft display window at 10 Rockefeller Plaza to ... in the heart of New York City, was generously donated by EHE International for the ... (PRWEB) ...
... Mass. -- Our DNA is under constant siege from a ... of cells to repair that damage has broad health implications, ... used to study DNA damage are quite limited, but MIT ... analysis that promises to make an impact on human health. ...
... 3, 2010) The results of new research results ... of the American College of Surgeons show that ... a hospital surgical ward. Postoperative pneumonia is ... third most common infectious complication after urinary tract and ...
Cached Medicine News:Health News:Hutchinson Center receives $10.24 million from NIH for Latina breast cancer research 2Health News:Hutchinson Center receives $10.24 million from NIH for Latina breast cancer research 3Health News:Hutchinson Center receives $10.24 million from NIH for Latina breast cancer research 4Health News:Hutchinson Center receives $10.24 million from NIH for Latina breast cancer research 5Health News:Research helps end guesswork in prescribing ADHD drug 2Health News:Young Physicians Taught to Practice Defensive Medicine, Survey Finds 2Health News:Young Physicians Taught to Practice Defensive Medicine, Survey Finds 3Health News:Lupus Awareness Month Kicks Off at Rockefeller Center: EHE International Donates Display Window to S.L.E. Lupus Foundation for May 2Health News:Lupus Awareness Month Kicks Off at Rockefeller Center: EHE International Donates Display Window to S.L.E. Lupus Foundation for May 3Health News:Rapid analysis of DNA damage now possible 2Health News:Surgeons' pilot prevention program reduces incidence of postoperative pneumonia 2
(Date:10/31/2014)... Oct. 31, 2014  Zacks.com announces the list of stocks featured ... discuss the latest news and events impacting stocks and the financial ... AMGN - Free Report ), Celgene (Nasdaq: ... BIIB - Free Report ), Market Vectors Biotech ETF (AMEX: ... Biotech ETF (AMEX: XBI - Free Report ). ...
(Date:10/31/2014)... BARCELONA , October 31, 2014 ... infringe two Australian patents of B. Braun Melsungen AG (B. ... Australia safety IV catheters manufactured by Poly Medicure ... Australia proceeding number VID 463 of ... In the detailed judgment, Multigate was found to have ...
(Date:10/31/2014)... 2014 Electronic prescribing or E-Prescribing ... prescription related information between prescriber, dispenser and ... physician and nurse practitioner to transmit a ... occurs during pharmacy operations. E-Prescribing system has ... complete medical lists, conducts all security checks ...
Breaking Medicine Technology:The Zacks Analyst Blog Highlights: Amgen, Celgene, Biogen Idec, Market Vectors Biotech ETF and SPDR S&P Biotech ETF 2The Zacks Analyst Blog Highlights: Amgen, Celgene, Biogen Idec, Market Vectors Biotech ETF and SPDR S&P Biotech ETF 3The Zacks Analyst Blog Highlights: Amgen, Celgene, Biogen Idec, Market Vectors Biotech ETF and SPDR S&P Biotech ETF 4The Zacks Analyst Blog Highlights: Amgen, Celgene, Biogen Idec, Market Vectors Biotech ETF and SPDR S&P Biotech ETF 5The Zacks Analyst Blog Highlights: Amgen, Celgene, Biogen Idec, Market Vectors Biotech ETF and SPDR S&P Biotech ETF 6The Zacks Analyst Blog Highlights: Amgen, Celgene, Biogen Idec, Market Vectors Biotech ETF and SPDR S&P Biotech ETF 7B. Braun Wins Patent Disputes Against Poly Medicure Ltd's Australian Distributor Multigate Medical Devices Pty. Ltd. and Spanish Distributor Dextromédica S. L. 2E-Prescribing Market - Global Industry Analysis, Size, Share, Growth, Trends and Forecast, 2013 - 2019 2
... Feb. 14, 2012 The Alliance for Safe Biologic ... Thursday, February 16th at 3:30 p.m. EST, focusing on biologic medicines ... of the Alliance, will also discuss the newly released ... Webinar III: Pharmacovigilance: What is it and why ...
... Feb. 14, 2012 The Center for Regulatory ... slash reimbursement to state Medicaid programs for beneficiaries ... Equipment.  The proposed budget would cripple the ability ... Instead of protecting the viability of home medical ...
Cached Medicine Technology:Alliance for Safe Biologic Medicines Announces New Webinar on February 16 2President's Budget Declares War on Medicaid Recipients 2
Microwell IRMA for the detection of Intact PTH...
Mircrowell EIA for detection of Intact PTH...
... Loading Units with Stainless Steel Staples for ... ,Utilizing a disposable loading unit, the LDS-2™ ... ligate the tissue within the cartridge jaw ... between the two closed clips. The instrument ...
... The Auto Suture™ Powered LDS™ single ... ligate tissue within the cartridge jaw and ... the two closed staples. , ,The ... with titanium staples have application in abdominal, ...
Medicine Products: