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New Study Data: JANUVIA™ (sitagliptin) Significantly Reduced Blood Sugar Levels and Was Not Associated with Hypoglycemia in Elderly Patients with Type 2 Diabetes
Date:11/21/2008

and periodically thereafter. Creatinine clearance can be estimated from serum creatinine using the Cockcroft-Gault formula. [See Clinical Pharmacology (12.3).

  • Concomitant Use with a Sulfonylurea

When JANUVIA is used in combination with a sulfonylurea, a lower dose of sulfonylurea may be required to reduce the risk of hypoglycemia. [See Warnings and Precautions (5.2).

  • DOSAGE FORMS AND STRENGTHS

  • 100mg tablets are beige, round, film-coated tablets with "277" on one side.

  • 50mg tablets are light beige, round, film-coated tablets with "112" on one side.

  • 25mg tablets are pink, round, film-coated tablets with "221" on one side.

  • CONTRAINDICATIONS

History of a serious hypersensitivity reaction to sitagliptin, such as anaphylaxis or angioedema. [See Warnings and Precautions (5.3) and Adverse Reactions (6.2).

  • WARNINGS AND PRECAUTIONS

  • Use in Patients with Renal Insufficiency


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