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IUD Proposed to Treat Uterine Cancer
Date:9/29/2010

the patients with AEH, four later relapsed and required further treatment; of the women with early-stage cancer, two who had an initial complete response relapsed. However, all the women were alive and seemingly cancer-free by the end of the study after further treatment (either the IUD and GnRH treatment or a hysterectomy), the study reported.

"They did show a higher recurrence or progression rate with endometrial cancer than with AEH and that is consistent with other data," said Bakkum-Gamez, who added that the IUD method would not be appropriate for later-stage cancers, which tend to be more aggressive.

No adverse effects from treatment were noted, according to the researchers, who declared no conflicts of interest.

In background material, the researchers stated the progestin-releasing IUD should be effective in treating AEH and also early endometrial cancer, as long as those patients were evaluated with laparoscopy, ultrasound and MRI to make sure their cancer had not spread and there was no simultaneous ovarian cancer.

Nine of the women in the study successfully delivered babies.

More information

The National Cancer Institute has more on endometrial cancer.

SOURCES: Jamie Bakkum-Gamez, M.D. senior associate consultant, division of gynecologic surgery, Mayo Clinic, Rochester, Minn.; Angeles Alvarez Secord, M.D., associate professor of gynecology oncology, Duke Comprehensive Cancer Center, Durham, NC; Elizabeth A. Poynor, M.D., Ph.D., gynecologic oncologist and pelvic surgeon, Lenox Hill Hospital, New York City; Annals of Oncology


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