Navigation Links
Higher Oxygen Levels Improve Preemie Survival: Study
Date:4/27/2011

By Steven Reinberg
HealthDay Reporter

WEDNESDAY, April 27 (HealthDay News) -- Babies born prematurely need supplemental oxygen to survive, but just how much has been a matter of debate.

A new report finds higher oxygen concentrations improve survival, but not without risks.

There are dangers of giving too much oxygen, severe eye damage -- even blindness -- being the primary one, as well as lung and brain damage. But there are also dangers in giving too little oxygen, including death, a neonatal expert said.

"The problem is we are dealing with the risks associated with high oxygen, which everybody has been trying to avoid up until now," said Dr. Eduardo H. Bancalari, director of the University of Miami Miller School of Medicine's Division of Neonatology.

"I think that in an effort to avoid the complications of high oxygen, the pendulum had gone too far to the other side," said Bancalari, who was not involved with the new research. "Babies have been receiving concentrations that are too low that are also associated with complications -- in these cases increased death."

Bancalari noted that getting the right concentration of oxygen isn't easy. "You are walking a tightrope," he said. "The problem is to find the right balance, which is difficult because it is a continuously moving target."

In the April 28 issue of the New England Journal of Medicine, Dr. Ben Stenson, of the University of Edinburgh in Scotland, and colleagues report on two studies that included 3,631 infants born before 28 weeks of gestation. Oxygen concentrations of 91 percent to 95 percent improved survival, compared with concentrations of 85 percent to 89 percent, the researchers found.

After 36 weeks, 14.4 percent of the infants on higher concentrations of oxygen had died, compared with 17.3 percent of those on the lower concentrations, the results showed.

Looking only at 1,055 infants in a trial done in Australia and the United Kingdom, the so-called BOOST II trial, 13.3 percent of the babies on high concentrations of oxygen died, compared with 21.8 percent of the children on the lower concentration, the researchers reported.

Based on these findings, both the BOOST II trial and a U.S.-based trial called the SUPPORT trial stopped recruiting new patients, the researchers noted.

Stenson's team concluded: "These data allow no inferences about risks and benefits of other targets. Until longer-term data on survival and morbidity are available, we consider it prudent not to target an [oxygen saturation] of 85 to 89 percent in infants born earlier than 28 weeks of gestation."

Bancalari thinks the message for doctors is one of balance.

"We cannot go from one extreme to another; we have to stay in a range that achieves both avoidance of too much or too little oxygen. That's easy to say, but in the clinical setting is very difficult to accomplish," he said.

Bancalari said his neonatal unit never went to the low end of oxygen concentrations, but rather uses a range of 88 percent to 93 percent.

More information

For more on premature birth, visit the March of Dimes.

SOURCES: Eduardo H. Bancalari, M.D., professor, pediatrics, obstetrics and gynecology, and director, division of neonatology, University of Miami Miller School of Medicine; April 28, 2011, New England Journal of Medicine


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Higher levels of social activity decrease the risk of cognitive decline
2. Newer Pill Linked to Higher Risk of Blood Clots
3. Higher Death Rates Seen in Central Line Dialysis Patients: Study
4. Children With HIV at Higher Risk of Drug Resistance
5. Minorities born with heart defects at higher risk of dying in early childhood than whites
6. Crash rates may be higher for teen drivers who start school earlier in the morning
7. Higher Rate of Morning Heart Attacks Not Due to Blood Pressure: Study
8. Potato consumption in childrens meals leads to higher overall diet quality
9. Babies Born to Obese Moms Face Higher Death Risk: Study
10. Patients on Higher Doses of Prescription Painkillers More Apt to Overdose
11. Older lesbians, gays have higher rates of chronic disease, mental distress, isolation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/21/2017)... (PRWEB) , ... April 21, 2017 , ... Providing for ... understand the estate planning process, or where to even begin. “Now more than ever ... you are to properly protect yourself and your family,” said attorney Lisa Edgar Dickman, ...
(Date:4/21/2017)... ... April 21, 2017 , ... Westside Dental Associates ... dental care since 1985. After thirty-two years, Dr. Latner has become one of the ... my numerous clients over the years with all their dental needs,” said Dr. Latner, ...
(Date:4/21/2017)... ... ... Each year, everyone is urged to give back to the earth on April ... a better future. However, supporting the environment should be an everyday practice. , ... to five times more polluted than outdoor air, reports the Environmental Protection Agency -- ...
(Date:4/21/2017)... Houston, Texas (PRWEB) , ... April 21, 2017 ... ... repeal…. sound familiar? These are five common elements between the Obamacare program ... feral hog control program which uses Warfarin poison to kill hogs. , ...
(Date:4/21/2017)... ... April 21, 2017 , ... Indiana ... significant bandwidth upgrade infrastructure service to Tele-Media Solutions. IFN is delivering Multi-Gigabit ... IFN’s consortium member-owners, Tele-Media Solution’s protect transport with 3GB Dual Access Internet access ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... Eyevensys, a private biotechnology company developing its ... that enables the safe, local, sustained production of therapeutic ... of ophthalmic diseases, announces it has received approval from ... to advance its technology into clinical development. ... The EyeCET platform uses ...
(Date:4/20/2017)... Research and Markets has announced the addition of ... By Service (Manufacturing, Research), By Country, (Brazil, Mexico, Colombia, Argentina, ... to their offering. ... The Latin American pharmaceutical contract manufacturing services market is anticipated ... drug registration cost in Latin American countries and continuous economic ...
(Date:4/19/2017)... , April 19, 2017 Cardiology devices segment ... projected period The Cardiology Devices segment is likely ... US$ 15 Mn in 2018 over 2017. By the end ... market valuation close to US$ 700 Mn, expanding at a ... segment dominated the Asia Pacific reprocessed ...
Breaking Medicine Technology: