Navigation Links
Higher Oxygen Levels Improve Preemie Survival: Study
Date:4/27/2011

By Steven Reinberg
HealthDay Reporter

WEDNESDAY, April 27 (HealthDay News) -- Babies born prematurely need supplemental oxygen to survive, but just how much has been a matter of debate.

A new report finds higher oxygen concentrations improve survival, but not without risks.

There are dangers of giving too much oxygen, severe eye damage -- even blindness -- being the primary one, as well as lung and brain damage. But there are also dangers in giving too little oxygen, including death, a neonatal expert said.

"The problem is we are dealing with the risks associated with high oxygen, which everybody has been trying to avoid up until now," said Dr. Eduardo H. Bancalari, director of the University of Miami Miller School of Medicine's Division of Neonatology.

"I think that in an effort to avoid the complications of high oxygen, the pendulum had gone too far to the other side," said Bancalari, who was not involved with the new research. "Babies have been receiving concentrations that are too low that are also associated with complications -- in these cases increased death."

Bancalari noted that getting the right concentration of oxygen isn't easy. "You are walking a tightrope," he said. "The problem is to find the right balance, which is difficult because it is a continuously moving target."

In the April 28 issue of the New England Journal of Medicine, Dr. Ben Stenson, of the University of Edinburgh in Scotland, and colleagues report on two studies that included 3,631 infants born before 28 weeks of gestation. Oxygen concentrations of 91 percent to 95 percent improved survival, compared with concentrations of 85 percent to 89 percent, the researchers found.

After 36 weeks, 14.4 percent of the infants on higher concentrations of oxygen had died, compared with 17.3 percent of those on the lower concentrations, the results showed.

Looking only at 1,055 infants in a trial done in Australia and the United Kingdom, the so-called BOOST II trial, 13.3 percent of the babies on high concentrations of oxygen died, compared with 21.8 percent of the children on the lower concentration, the researchers reported.

Based on these findings, both the BOOST II trial and a U.S.-based trial called the SUPPORT trial stopped recruiting new patients, the researchers noted.

Stenson's team concluded: "These data allow no inferences about risks and benefits of other targets. Until longer-term data on survival and morbidity are available, we consider it prudent not to target an [oxygen saturation] of 85 to 89 percent in infants born earlier than 28 weeks of gestation."

Bancalari thinks the message for doctors is one of balance.

"We cannot go from one extreme to another; we have to stay in a range that achieves both avoidance of too much or too little oxygen. That's easy to say, but in the clinical setting is very difficult to accomplish," he said.

Bancalari said his neonatal unit never went to the low end of oxygen concentrations, but rather uses a range of 88 percent to 93 percent.

More information

For more on premature birth, visit the March of Dimes.

SOURCES: Eduardo H. Bancalari, M.D., professor, pediatrics, obstetrics and gynecology, and director, division of neonatology, University of Miami Miller School of Medicine; April 28, 2011, New England Journal of Medicine


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Higher levels of social activity decrease the risk of cognitive decline
2. Newer Pill Linked to Higher Risk of Blood Clots
3. Higher Death Rates Seen in Central Line Dialysis Patients: Study
4. Children With HIV at Higher Risk of Drug Resistance
5. Minorities born with heart defects at higher risk of dying in early childhood than whites
6. Crash rates may be higher for teen drivers who start school earlier in the morning
7. Higher Rate of Morning Heart Attacks Not Due to Blood Pressure: Study
8. Potato consumption in childrens meals leads to higher overall diet quality
9. Babies Born to Obese Moms Face Higher Death Risk: Study
10. Patients on Higher Doses of Prescription Painkillers More Apt to Overdose
11. Older lesbians, gays have higher rates of chronic disease, mental distress, isolation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/21/2017)... (PRWEB) , ... July 21, 2017 , ... ... management assistance and financial planning services to families and business owners in northern ... event that promises to provide support to area adults with developmental challenges. , ...
(Date:7/21/2017)... ... July 21, 2017 , ... Adolfson & ... and improve the Ramsey County Medical Examiners Facility located in Saint Paul, Minn. ... million project is scheduled to start in late 2017/early 2018. , Staffed ...
(Date:7/21/2017)... ... July 21, 2017 , ... ... Theater of Witness , was awarded a $300,000 grant from The Pew ... fosters empathy, comfort with ambiguity and the recognition of one’s own limits among ...
(Date:7/21/2017)... , ... July 21, 2017 , ... Bernard R. Bach, ... President of the American Orthopaedic Society of Sports Medicine (AOSSM) , received the ... the AOSSM Annual Meeting in Toronto, Canada. This prestigious award is given annually to ...
(Date:7/21/2017)... , ... July 21, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House ... use of violence and aggression to solve problems and pleads with world leaders to be ... armed forces do not bring peace. He says there is a peaceful and positive way ...
Breaking Medicine News(10 mins):
(Date:7/21/2017)... SPRING, Md. and RESEARCH TRIANGLE ... United Therapeutics Corporation (NASDAQ: UTHR ) announced ... financial results before the market opens on Thursday, July ... Therapeutics will host a teleconference on Thursday, July 27, ... accessible by dialing 1-877-351-5881, with international callers dialing 1-970-315-0533.  ...
(Date:7/19/2017)... , July 19, 2017  Mako Medical Laboratories partnered ... the Military Family Assistance Fund (MFA) to bring 140 ... to visit with their families one last time before ... coordinate the travel and logistics needed for these soldiers. ... soldiers and their families. We just wish we could ...
(Date:7/14/2017)... , July 13, 2017 It should come ... States is in the midst of a crippling ... , since 1999, the number of overdose deaths from opiate-based ... in over half a million dead from 2001 to 2015". ... oxycodone, and hydrocodone has similarly quadrupled, drawing a compelling link ...
Breaking Medicine Technology: