Navigation Links
Hebrew University scientist develop technique for eliminating reblockage of arteries
Date:3/9/2009

Jerusalem, March 9, 2009 An easily implementable technique to avoid reblockage of arteries that have been cleared through angioplasty and stent insertion has been developed by researchers led by Prof. Boris Rubinsky of the Hebrew University of Jerusalem.

Angioplasty is the "gold-standard" treatment for acute myocardial infarction (heart attack), which is the result of abrupt interruption in blood supply to part of the beating heart, usually due to plaque-rupture in an atherosclerotic (hardened) coronary artery.

In angioplasty, a cardiologist dilates the blocked artery by inserting a balloon that is inflated at the point of blockage. This is usually followed by coronary stent implantation to protect the artery and prevent restenosis (reocclusion or reblockage). However, the procedure damages the arterial wall, and therefore restonosis of the dilated artery remains a major clinical problem in cardiology, as well as in other fields of clinical medicine.

Since heart disease remains the leading cause of mortality in the western world, the technique developed by Prof. Rubinsky's research teams offer a highly valuable tool for dealing with cardiology patients. Prof. Rubinsky is the director of the Center for Bioengineering in the Service of Humanity and Society at the Rachel and Selim Benin School of Computer Science and Engineering of the Hebrew University of Jerusalem and a professor in the graduate school at the University of California, Berkeley.

The technique employs the biophysical phenomenon of irreversible electroporation (IRE). IRE destroys cells within seconds, using very short electric field pulses. It causes no damage to structures other than the cells themselves. Compared with other technologies for local destruction of cells and tissue, IRE is simple and does not require special training of the medical team.

In IRE, electrical fields are applied across targeted cells, penetrating the cell membranes, This process leads to cell death, since the electrical fields cause permanent damage to the membranes and the consequent loss of cell stability. The electrical fields damage only the cell membranes, with no collateral damage to other structures in the treated area. While the phenomenon of irreversible electroporation was known for decades, a team led by Prof. Rubinsky developed a new mode of application that affects only selected molecules in tissue, and as a consequence it has become only recently rigorously considered in medicine for various applications of tissue removal.

In an article published March 9 in the journal PLoS ONE, Prof. Rubinsky's team demonstrated that IRE can efficiently, safely and quickly destroy the cells responsible for the restenosis phenomenon in rats. In the study, IRE successfully destroyed almost all of those cells in less than 23 seconds, with no damage to any other structures. Clinical trials on humans for restenosis treatment are planned in the near future.

IRE has been recently used for the first time on human subjects in Melbourne, Australia, for the treatment of prostate, liver and lung tumors. Clinical trials for follow-up through IRE of angioplasty treatments are planned for the near future. Prof. Jay Lavee, head of the heart transplant unit at the Sheba Medical Center, Tel Hashomer, is cooperating with Prof. Rubinsky in development of the IRE technique for heart patients.


'/>"/>

Contact: Jerry Barach
jerryb@savion.huji.ac.il
972-258-82904
The Hebrew University of Jerusalem
Source:Eurekalert

Related medicine news :

1. Hebrew University scientists succeed through stem cell therapy in reversing brain birth defects
2. Event Honoring Bill Gates Raises Over $1.5 Million for Sustainable Agriculture Research at The Hebrew University of Jerusalem
3. The Connecticut Hospice, Inc. Announces the Arrival of Six Nurse Scholars From The Henrietta Szold-Hadassah-Hebrew University School of Nursing
4. RNA engineering to combat series of illnesses wins Kaye Award for Hebrew University dean
5. Hebrew University research on octopuses sheds light on memory
6. Humans have more distinctive hearing than animals, Hebrew U study shows
7. Robert H. Smith Feeding the Future with $15 Million Gift to Hebrew University of Jerusalem
8. Hebrew SeniorLife researcher finds
9. 2 Hebrew University scientists awarded Wolf Prizes
10. NorthShore University HealthSystem Only Hospital in the Region to Use Incisionless Procedure to Reduce Weight Regain
11. New Tel Aviv University research links diabetes to cognitive deterioration
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/18/2017)... Raton, Fl (PRWEB) , ... August 18, 2017 ... ... largest network of highly trained practitioners specializing in bioidentical hormone replacement therapy and ... associated with hormone imbalance and conditions of aging, such as menopause, andropause, thyroid ...
(Date:8/18/2017)... ... August 18, 2017 , ... “Our Mountains to Climb: A Journey ... couple that grew stronger together through the faith they shared to overcome struggles in ... the creation of published author, Barbara J. Corcoran, a retired teacher and happily married ...
(Date:8/18/2017)... New York, New York (PRWEB) , ... August ... ... the world’s leading manufacturers and marketers of high-quality anti-aging skincare solutions, ... Prache Antiaging Serum. These new products are an affordable, yet effective alternative to ...
(Date:8/17/2017)... ... August 17, 2017 , ... Riccobene ... new location in Goldsboro, NC to its family of practices. Residents of Goldsboro ... trademark starting August 15, 2017. , Riccobene Associates Family Dentistry, founded by ...
(Date:8/17/2017)... ... August 17, 2017 , ... ... of three years for its residential drug and alcohol detox program. This accreditation ... organization and shows the organization’s substantial conformance to the CARF standards. , Behavioral ...
Breaking Medicine News(10 mins):
(Date:8/8/2017)... TEL AVIV, Israel, Aug. 8, 2017  BioLineRx Ltd. ... and immunology, today reports its financial results for the ... and achievements during the second quarter 2017 and to ... on multiple clinical development programs for the Company,s lead ... Phase 3 pivotal study with BL-8040 as novel stem ...
(Date:8/7/2017)... 2017  Diplomat Pharmacy, Inc. (NYSE: DPLO), the nation,s largest ... June 30, 2017.  All comparisons, unless otherwise noted, are to ... Second Quarter 2017 Highlights include: ... an increase of 3.5% Total prescriptions dispensed ... of 7.5% versus 7.6% Gross profit ...
(Date:8/2/2017)... 2017 Fenita J. Caldwell ... Pinnacle Lifetime Professional in the Field of Healthcare. ... Turing Pharmaceuticals, AG. Her skills and areas of ... ... of experience as a highly successful sales specialist ...
Breaking Medicine Technology: