Navigation Links
Experimental Drugs Show Promise Against Prostate Cancer
Date:5/31/2013

FRIDAY, May 31 (HealthDay News) -- Researchers have identified a new class of drugs that show promise for treating advanced prostate cancer. The drugs, known as peptidomimetics, interfere with the signaling necessary for prostate cancer cells to grow, according to a new study.

Prostate cancer depends upon the actions of androgens, such as the "male" hormone testosterone. Androgens activate androgen receptors, resulting in a signal that causes prostate cancer cells to grow.

To stop tumor growth, men with prostate cancer have been treated with drugs to block the production of androgens or block the receptor where androgens bind. However, tumors can grow despite this treatment because of mutations in androgens or receptors.

In the latest study, published online May 28 in Nature Communications, a team of researchers led by Dr. Ganesh Raj, associate professor of urology at UT Southwestern Medical Center at Dallas, found the nontoxic peptidomimetic agents could disrupt androgen-receptor signaling and prevent tumor growth.

When tested in mouse and human tissue models, the drugs blocked the activity of androgens by attacking the protein in a different spot from where the androgen binds, the researchers explained. As a result, prostate cancer cells do not receive the signal to grow -- even when the androgen receptor is activated.

"We are hopeful that this novel class of drugs will shut down androgen-receptor signaling and lead to added options and increased longevity for men with advanced prostate cancer," Raj, the study's senior author, noted in a university news release.

The researchers noted more testing is needed before the drugs could progress to clinical trials involving humans. Results obtained in laboratory experiments are not always replicated in humans.

"Most drugs now available to treat advanced prostate cancer improve survival rates by three or four months," Raj added. "Our new agent
'/>"/>

Copyright©2012 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. Experimental Drug Seems to Aid Memory in Mice With Alzheimers
2. Mayo Clinic finds experimental drug inhibits growth in all stages of common kidney cancer
3. Experimental Drug for Hepatitis C Promising, Studies Show
4. Experimental Vaccine Shows Promise for Ovarian Cancer
5. Cisplatin-resistant cancer cells sensitive to experimental anticancer drugs, PARP inhibitors
6. Experimental Staph Vaccine Fails to Work, Study Finds
7. Experimental Drug May Work Against Hepatitis C
8. Experimental Alzheimers Drug Shows Promise, Study Finds
9. Experimental Vitiligo Treatment Shows Promise in Mice
10. Harmful effects of bisphenol A proved experimentally
11. Experimental agent briefly eases depression rapidly in test
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
 Experimental Drugs Show Promise Against Prostate Cancer
(Date:8/28/2014)... August 28, 2014 Top 10 ... web hosting companies and announces Bluehost, HostMonster ( ... suppliers for the webmasters worldwide who want to ... , As the world’s most popular server-side scripting ... many other general-purpose programs. It is now installed ...
(Date:8/28/2014)... ChiLiving® will host its inaugural ... at holistic retreat center, Om Sanctuary. This active ... and Danny Dreyer, offers beginner to seasoned runners ... support a lifetime of pain-free, injury-free movement in ... the heart of the Blue Ridge Mountains during ...
(Date:8/28/2014)... 28, 2014 Now in its 4th year, ... started in 2011 by two brain aneurysm survivors. The ongoing ... awareness, provide education to help increase early detection and to ... a brain aneurysm. We hope that you will be able ... at the 4th Annual Step for Hope Run/ Walk on ...
(Date:8/28/2014)... Alpine, NJ resident Othon Mourkakos is ... Zebras In Tiaras, to benefit the Immune Deficiency Foundation ... 26, 2014 in Foley Square, New York. IDF ... immunodeficiency diseases (PI) are a group of more than ... the body’s immune system is missing or functions improperly. ...
(Date:8/28/2014)... Livermore, CA (PRWEB) August 28, 2014 ... newest California physician, James Patel M.D. of Livermore, California. ... the best and most qualified physicians, and in accordance ... and our patients to Dr. Patel’s practice. , Initially ... at a young age, Dr. Patel was shaped by ...
Breaking Medicine News(10 mins):Health News:Join ChiRunning® & ChiWalking® Creators, Katherine and Danny Dreyer, for First-ever ChiWeekend Retreat in Asheville, NC 2Health News:Join ChiRunning® & ChiWalking® Creators, Katherine and Danny Dreyer, for First-ever ChiWeekend Retreat in Asheville, NC 3Health News:Step for Hope and Raise Brain Aneurysm Awareness 2Health News:Army Colonel Dr. James Patel Joins the Medical Marijuana Industry 2Health News:Army Colonel Dr. James Patel Joins the Medical Marijuana Industry 3Health News:Army Colonel Dr. James Patel Joins the Medical Marijuana Industry 4
... , THURSDAY, May 17 (HealthDay News) -- Smoking ... and 2010, but too many of them still light up, ... current cigarette use among U.S. teens decreased from nearly 12 ... dropped from nearly 40 percent to about 34 percent among ...
... patients with one of the most common causes of blindness ... partnership. Researchers from the University of Strathclyde and Stanford ... of age related macular degeneration (AMD), which affects one in ... in eight aged over 85. The device would be ...
... Mental distractions can act as a form of pain relief, ... to complete a difficult or easy memory task while a ... participants perceived less pain when they were more distracted by ... MRI, the German researchers also found that the lower levels ...
... (May 16, 2012)If racial and ethnic disparities in breast cancer ... of imaging to assess the extent of tumors before surgery, ... Chase Cancer Center researchers at the 2012 Annual Meeting of ... "It,s encouraging that we didn,t see any differences between ...
... ALEXANDRIA, Va. The American Society of Clinical Oncology ... from among more than 4,500 abstracts publicly posted online ... Plenary, late-breaking and other major studies will be ... to be held June 1-5, 2012, at McCormick Place ...
... Macmillan Survivorship Research Group (MSRG), at the University of Southampton, ... the experiences and needs of people after primary treatment of ... people are living with, or beyond, cancer in the UK, ... average over 6,000 patients are diagnosed with cancer each year ...
Cached Medicine News:Health News:Fewer Young Americans Smoking, Survey Finds 2Health News:Prosthetic retina offers simple solution to restoring sight 2Health News:Prosthetic retina offers simple solution to restoring sight 3Health News:Fox Chase researchers find no disparities in imaging before breast cancer surgery 2Health News:ASCO releases studies from upcoming annual meeting 2Health News:Researchers undertake radical new cancer survivorship study 2Health News:Researchers undertake radical new cancer survivorship study 3
(Date:8/27/2014)... August 27, 2014 According ... Products (Dental Radiology, CAD/CAM, Dental Chairs, Dental Lasers), Current Trends, ... MarketsandMarkets, the global Dental Equipment Market is expected to ... in 2014, growing at a CAGR of 5.7% ... market data tables and 61 figures spread through ...
(Date:8/27/2014)... Pulse Systems, Inc. , an industry-leading provider of ... Revenue Cycle Management (RCM) solutions , will reveal some ... vendors, at UBM Medica,s Practice Rx conference in ... A presenter at the May Practice Rx ... session encouraging practices to "Look before You Leap: Understanding Revenue ...
(Date:8/27/2014)... Aug. 27, 2014 Sihuan Pharmaceutical Holdings ... "Company"), a leading pharmaceutical company with the largest ... China,s prescription drug market, today announced ... its subsidiaries (collectively the "Group") for the six ... Financial HighlightsFor the Six months ended 30 ...
Breaking Medicine Technology:Dental Equipment Market Worth $7,138.9 Million by 2019 2Dental Equipment Market Worth $7,138.9 Million by 2019 3Pulse Systems Presents the Truth about Revenue Cycle Management Services at Practice Rx 2Pulse Systems Presents the Truth about Revenue Cycle Management Services at Practice Rx 3Pulse Systems Presents the Truth about Revenue Cycle Management Services at Practice Rx 4Sihuan Pharmaceutical Announces 2014 Interim Results 2Sihuan Pharmaceutical Announces 2014 Interim Results 3Sihuan Pharmaceutical Announces 2014 Interim Results 4Sihuan Pharmaceutical Announces 2014 Interim Results 5Sihuan Pharmaceutical Announces 2014 Interim Results 6Sihuan Pharmaceutical Announces 2014 Interim Results 7
... SAN DIEGO , July 29 Orexigen® Therapeutics, Inc. (Nasdaq: ... its second quarter ended June 30, 2010 financial results on ... followed by a live webcast and conference call at 5:00 p.m. Eastern ... Orexigen management will ...
... , EMERYVILLE, Calif. , July 29 Bionovo, Inc. ... from the European Medicines Agency (EMA) in order to advance Menerba, the ... in Europe . The guidance defines the clinical and regulatory pathway ... , , ...
Cached Medicine Technology:Orexigen® Therapeutics Schedules August 5, 2010 Webcast Discussion of Financial Results for the Second Quarter Ended June 30, 2010 2Bionovo to Advance Menerba to Phase 3 Clinical Testing in Europe 2Bionovo to Advance Menerba to Phase 3 Clinical Testing in Europe 3
A system with integrated pupil camera and 7" examination monitor. An easy to use configuration....
The only air-based esthesiometer with a database of normal sensation on the cornea. May have application to the measurement of normal-tension glaucoma....
Produce clean 0.75 mm round hole without tissue tags. Serrated squeeze action handle....
Brightness acuity tester....
Medicine Products: