Navigation Links
Experimental Drugs Show Promise Against Prostate Cancer
Date:5/31/2013

FRIDAY, May 31 (HealthDay News) -- Researchers have identified a new class of drugs that show promise for treating advanced prostate cancer. The drugs, known as peptidomimetics, interfere with the signaling necessary for prostate cancer cells to grow, according to a new study.

Prostate cancer depends upon the actions of androgens, such as the "male" hormone testosterone. Androgens activate androgen receptors, resulting in a signal that causes prostate cancer cells to grow.

To stop tumor growth, men with prostate cancer have been treated with drugs to block the production of androgens or block the receptor where androgens bind. However, tumors can grow despite this treatment because of mutations in androgens or receptors.

In the latest study, published online May 28 in Nature Communications, a team of researchers led by Dr. Ganesh Raj, associate professor of urology at UT Southwestern Medical Center at Dallas, found the nontoxic peptidomimetic agents could disrupt androgen-receptor signaling and prevent tumor growth.

When tested in mouse and human tissue models, the drugs blocked the activity of androgens by attacking the protein in a different spot from where the androgen binds, the researchers explained. As a result, prostate cancer cells do not receive the signal to grow -- even when the androgen receptor is activated.

"We are hopeful that this novel class of drugs will shut down androgen-receptor signaling and lead to added options and increased longevity for men with advanced prostate cancer," Raj, the study's senior author, noted in a university news release.

The researchers noted more testing is needed before the drugs could progress to clinical trials involving humans. Results obtained in laboratory experiments are not always replicated in humans.

"Most drugs now available to treat advanced prostate cancer improve survival rates by three or four months," Raj added. "Our new agents may offer hope for men who fail with the current drugs."

More information

The U.S. National Cancer Institute has more about treatment for prostate cancer.

-- Mary Elizabeth Dallas

SOURCE: UT Southwestern, news release, May 28, 2013


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Experimental Drug Seems to Aid Memory in Mice With Alzheimers
2. Mayo Clinic finds experimental drug inhibits growth in all stages of common kidney cancer
3. Experimental Drug for Hepatitis C Promising, Studies Show
4. Experimental Vaccine Shows Promise for Ovarian Cancer
5. Cisplatin-resistant cancer cells sensitive to experimental anticancer drugs, PARP inhibitors
6. Experimental Staph Vaccine Fails to Work, Study Finds
7. Experimental Drug May Work Against Hepatitis C
8. Experimental Alzheimers Drug Shows Promise, Study Finds
9. Experimental Vitiligo Treatment Shows Promise in Mice
10. Harmful effects of bisphenol A proved experimentally
11. Experimental agent briefly eases depression rapidly in test
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
 Experimental Drugs Show Promise Against Prostate Cancer
(Date:6/26/2017)... ... , ... New patients with missing teeth in Fitchburg, WI, can ... Dr. Cotey is a trusted dentist who has placed many dental implants and enjoys ... missing teeth in Fitchburg, WI, are encouraged to find out if they are candidates ...
(Date:6/25/2017)... ... June 25, 2017 , ... Republicans in the United States Senate on ... the Better Care Reconciliation Act. It differs significantly from the American Health Care Act, ... reconciled in committee, or the House will have to take up the Senate version ...
(Date:6/25/2017)... CA (PRWEB) , ... June 25, 2017 , ... With a heatwave currently bearing down ... or hanging out at the pool. Being swimsuit ready is easy with laser hair removal. ... and repeat again can be a burdensome routine when all you want to do is ...
(Date:6/24/2017)... ... June 24, 2017 , ... ... at the Sheraton Erie Bayfront and Erie Convention Center on June 8-10. ... exhibits, a student quiz bowl, award and scholarship presentations, and professional networking. ...
(Date:6/24/2017)... ... ... Doorknobs are for convenience, deadbolts are for security. , There are many ... an alarm system installed. But unless there is a working deadbolt lock that is ... Premier Locksmith in Killeen, TX says: “In the majority of home burglaries, intruders use ...
Breaking Medicine News(10 mins):
(Date:6/20/2017)...  Hill-Rom Holdings, Inc. (NYSE: HRC), will host its fiscal ... July 28, 2017, beginning at 7:30 a.m. (CDT) / 8:30 ... To participate in the conference call, dial (877) 304-8969 (domestic) ... least 10 minutes prior to the start to allow time ... Webcast: A simultaneous webcast of the ...
(Date:6/14/2017)... 14, 2017 The Bio Supply Management Alliance ... of Fremont and the Biomedical Manufacturing Network ... in California by providing a ... and fostering workforce development. The primary focus of this ... start-ups, as well as small and mid-sized biomedical companies. ...
(Date:6/10/2017)... BESSEMER, Ala. , June 9, 2017  Shane K. Burchfield, ... Member recognized for excellence as a Podiatrist in Alabama ... of Podiatry at Family First Foot Care. He brings over 20 ... sports medicine, pain management and healthcare, to his role. ... Family First Foot Care, PC is pleased to welcome ...
Breaking Medicine Technology: