Navigation Links
Experimental Drugs Show Promise Against Prostate Cancer
Date:5/31/2013

FRIDAY, May 31 (HealthDay News) -- Researchers have identified a new class of drugs that show promise for treating advanced prostate cancer. The drugs, known as peptidomimetics, interfere with the signaling necessary for prostate cancer cells to grow, according to a new study.

Prostate cancer depends upon the actions of androgens, such as the "male" hormone testosterone. Androgens activate androgen receptors, resulting in a signal that causes prostate cancer cells to grow.

To stop tumor growth, men with prostate cancer have been treated with drugs to block the production of androgens or block the receptor where androgens bind. However, tumors can grow despite this treatment because of mutations in androgens or receptors.

In the latest study, published online May 28 in Nature Communications, a team of researchers led by Dr. Ganesh Raj, associate professor of urology at UT Southwestern Medical Center at Dallas, found the nontoxic peptidomimetic agents could disrupt androgen-receptor signaling and prevent tumor growth.

When tested in mouse and human tissue models, the drugs blocked the activity of androgens by attacking the protein in a different spot from where the androgen binds, the researchers explained. As a result, prostate cancer cells do not receive the signal to grow -- even when the androgen receptor is activated.

"We are hopeful that this novel class of drugs will shut down androgen-receptor signaling and lead to added options and increased longevity for men with advanced prostate cancer," Raj, the study's senior author, noted in a university news release.

The researchers noted more testing is needed before the drugs could progress to clinical trials involving humans. Results obtained in laboratory experiments are not always replicated in humans.

"Most drugs now available to treat advanced prostate cancer improve survival rates by three or four months," Raj added. "Our new agents may offer hope for men who fail with the current drugs."

More information

The U.S. National Cancer Institute has more about treatment for prostate cancer.

-- Mary Elizabeth Dallas

SOURCE: UT Southwestern, news release, May 28, 2013


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Experimental Drug Seems to Aid Memory in Mice With Alzheimers
2. Mayo Clinic finds experimental drug inhibits growth in all stages of common kidney cancer
3. Experimental Drug for Hepatitis C Promising, Studies Show
4. Experimental Vaccine Shows Promise for Ovarian Cancer
5. Cisplatin-resistant cancer cells sensitive to experimental anticancer drugs, PARP inhibitors
6. Experimental Staph Vaccine Fails to Work, Study Finds
7. Experimental Drug May Work Against Hepatitis C
8. Experimental Alzheimers Drug Shows Promise, Study Finds
9. Experimental Vitiligo Treatment Shows Promise in Mice
10. Harmful effects of bisphenol A proved experimentally
11. Experimental agent briefly eases depression rapidly in test
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
 Experimental Drugs Show Promise Against Prostate Cancer
(Date:2/17/2017)... ... February 17, 2017 , ... Smiles by Seese is a comprehensive ... NC. Dr. Brian Seese leads the practice as a skilled and highly credentialed dentist ... Smiles by Seese serves patients of all ages with excellence in general, restorative, and ...
(Date:2/17/2017)... ... February 17, 2017 , ... ... allow for the electronic prescribing of controlled and non-controlled substances plus the ability ... of pharmacies in the United States now accept electronic prescriptions, according to the ...
(Date:2/17/2017)... ... February 17, 2017 , ... Empowering ... Francis' goals for each and every seminar, session and class she offers. ... five different brainwave tools which help energize creativity, focus mental functions, enhance athletic ...
(Date:2/17/2017)... ... February 17, 2017 , ... Access ... & Exhibition in Orlando, Fla., February 19-23. Visitors to the company’s booth (#1778) ... widely used electronic patient signatures solution in healthcare . , Since it ...
(Date:2/17/2017)... ... February 17, 2017 , ... Pharmica ... focusing on all facets of clinical trial planning and management. Pharmica discussed the ... and more. In addition, attendees stopping by Pharmica’s booth were able to demo ...
Breaking Medicine News(10 mins):
(Date:2/17/2017)... NEW YORK , Feb. 17, 2017 /PRNewswire/ ... announced today the partnership of their 3D body ... in healthcare IT.  The new integration will be ... on an interactive model of the human body. ... data saves clinicians time, while also increasing the ...
(Date:2/16/2017)... , Feb. 16, 2017 Absorption Systems, ... and medical devices, is pleased to announce that its ... been selected as a winner of the 2017 Executive ... Magazine and recognizes driven executives for their creative ... ethic. The awards ceremony and celebration is on March ...
(Date:2/16/2017)... (NYSE: DVA ) today announced results for the ... Net income attributable to DaVita Inc. for the quarter and ... per share and $880 million, or $4.29 per share, respectively. ... for the quarter and year ended December 31, 2016, excluding ... per share, and $789 million, or $3.85 per share, respectively. ...
Breaking Medicine Technology: