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-Contrave(R) Obesity Research Phase 3 Program Meets Co-Primary and Key Secondary Endpoints; Exceeds FDA Efficacy Benchmark for Obesity Treatments-
Date:7/20/2009

eb site at http://www.Orexigen.com and will be archived for 14 days following the call.

About Contrave

Contrave is an investigational medication for the treatment of obesity believed to have a unique mechanism of action that works at two levels within the central nervous system: one associated with controlling the balance of food intake and metabolism and another involved in controlling food preference, reward and cravings. We believe that Contrave has the potential to be the first treatment for obesity to target both of these reward centers in the central nervous system. Contrave is believed to initiate and sustain significant weight loss over one year of treatment by reducing appetite, increasing metabolism and allowing the body to continue losing weight by offsetting its natural tendency to fight back and slow down the weight loss process.

Orexigen reported the results of the COR-BMOD (NB-302) trial in January 2009. This was a 56-week trial designed to assess the safety, tolerability and efficacy of Contrave32 versus placebo in 793 obese patients combined with an underlying intensive behavior modification regimen. The trial was conducted at nine U.S. centers. Patients in that trial who completed one year of treatment on Contrave lost 11.5% of their body weight, compared to 7.3% on placebo.

About Orexigen(R) Therapeutics

Orexigen Therapeutics, Inc. is a biopharmaceutical company focused on the treatment of obesity. The Company's lead investigational product, Contrave, has completed Phase 3 clinical trials and is on track for a regulatory submission with the FDA in the first half of 2010. The Company's second product, Empatic(TM), is in the later stages of Phase 2 clinical development, with results expected in the second half of 2009. Each product c
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SOURCE Orexigen Therapeutics, Inc.
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