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/C O R R E C T I O N -- Nycomed/
Date:9/10/2009

t of the condition on their daily lives.

    - On average each patient had 3 episodes of BTCP per day

    - Each episode had an average duration of 60 minutes

    - 96% of the pain episodes were described as moderate to severe

    - For 87% of patients their BTCP interfered with their daily living
      including their ability to sleep, walk and get on with other people

"The study documents that breakthrough pain has a significant impact on cancer patients' daily lives," explained Dr. Andrew Davies, Department of Palliative Medicine, Royal Marsden Hospital, UK and the principal investigator of this survey. "Breakthrough pain is very different to background pain. Background pain is a continuous, chronic pain requiring around-the-clock medication. Breakthrough pain is a fast onset, short duration, intense pain that breaks through the chronic pain even when this is being controlled with medication. It is incapacitating and very distressing to the patient."

For this kind of pain episode the ideal treatment would be fast acting with short duration of action to most closely match the nature of BTCP episodes. Moreover, it must be easy to use to improve patient compliance. However, the results of the survey show that:

    - 98% of patients were using orally administered drugs
    - The time to first noticing a reduction in pain was on average 20
      minutes
    - The time to knowing that the pain medication was really making a
      difference was on average 30 minutes or half way through the typical
      BTCP episode observed in this survey

"Oral opioids are still commonly used to manage BTCP despite the fact that the way these drugs work does not match the characteristics of a BTCP episode. Opioids given by other routes, for example intranasal, have significant advantages over oral opioids and the interim results from this survey suggest that these routes wou
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