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Bruker Daltonics Showcasing Novel Proteomics Solutions Based on Mass Spectrometry at the 7th HUPO World Congress 2008
Date:8/17/2008

the line ultraflex™ III TOF/TOF system for the characterization of PEGylation sites and other protein modifications of vital importance in fields such as recombinant protein production, biologics drug development and quality control. MALDI-TDS has clearly proven its usefulness in the recent ABRF Protein Research Group (PRG) 2008 Study for the identification and differentiation of various truncated proteins of the same origin and provided 100% protein sequence coverage. Bruker's unique SmartBeam™ is the enabling technology for MALDI-TDS, complemented by next generation BioTools 3.2 top-down bioinformatics. The high sensitivity SmartBeam™ MALDI ion funnel source has now been coupled with the ultra-high mass resolution apex-ultra™ FTMS, representing a 'perfect match' for MALDI small molecule tissue imaging, including drugs and metabolites from animals dosed at therapeutic levels, e.g. at or below 5 mg/kg. With mass resolution greater than 900,000 (at 7 Tesla), the cluttered spectra produced in small molecule MALDI imaging of tissue samples are readily resolved, allowing for the first time MALDI-MS imaging of small molecules without the requirement to use MS/MS (SRM) for chemical background suppression. The high mass accuracy combined with Bruker's SmartFormula™ software automatically provides sum formula determination for detected molecules. This new imaging solution promises to advance areas such as drug development and delivery, clinical and pathology research, as well as other areas such as lipidomics. EASY-nLC™ is a Bruker-supported nanoscale LC system with 1D and 2D separation capabilities. Due to the true split-free gradient mixing it avoids cumbersome maintenance, and guarantees robust, steady and reliable operation. EASY-nLC dramatically reduces total solvent consumption and enables fast separations with peak widths less than 5 sec. The control by Bruker's Hystar™ software supports all proteomics applications on the max
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 Bruker Daltonics Showcasing Novel Proteomics Solutions Based on Mass Spectrometry at the 7th HUPO World Congress 2008 
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