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Big-hearted fish reveals genetics of cardiovascular condition
Date:2/25/2009

the disease present in the affected endothelial cells themselves, or in the cells that surround them, such as neurons in the brain?

"We think the developmental model has shown us that the requirement is in the endothelial cell," he says.

Now Kahn, Kleaveland, and their colleagues are working to determine just what it is that HEG is doing in endothelial cell-cell junctions what proteins it "talks" to on adjacent endothelial cells and also, to build a true mouse model of the CCM disease.

The mice in this study died in utero, but CCM disease tends to affect humans in their 30s and older. With a good model, however, "you could watch the progression of it, and you could try to change that progression, essentially to treat a mouse," Kleaveland says.


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Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

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