Navigation Links
Avastin Rejection Supported by Cancer Experts
Date:7/4/2011

By Steven Reinberg
HealthDay Reporter

FRIDAY, July 1 (HealthDay News) -- Oncologists and even some breast cancer support groups are endorsing a U.S. health advisory panel's recommendation that the blockbuster cancer drug Avastin be removed for use in metastatic breast cancer.

The reason: There's still a lack of understanding of how the drug works or who it helps.

Avastin was given fast-track approval by the U.S. Food and Drug Administration in 2008 to be used, in combination with the chemotherapy drug Taxol, by women with metastatic HER2-negative breast cancer.

But a six-member FDA panel of cancer experts said Wednesday that the drug was not effective, caused dangerous side effects and its approval should be revoked.

The decision, which is non-binding, came at the end of a two-day hearing granted to Avastin maker Genentech after the FDA recommended last December revoking the drug's approval for metastatic breast cancer. The FDA cited the medication's poor performance in follow-up studies and its potential for serious side effects.

Karuna Jaggar, executive director of Breast Cancer Action, told HealthDay that "the panel made the right decision. We have been advocating for the FDA to take a critical stand on Avastin and really focus on overall survival," which hasn't been proven by any of the drug's studies so far.

Dr. Paula Klein, an oncologist specializing in breast cancer at Beth Israel Medical Center in New York City, said there may well be a subset of women for whom Avastin will extend life. But she faulted the drug maker for not trying to identify that group. "What Genentech has failed to do is spend the money necessary to find the subset of breast cancer patients that will benefit," she said.

Jaggar said she wished the evidence supporting Avastin had been stronger. She said she would support having Genentech doing a trial to try to identify women who would benefit from the
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved

Page: 1 2 3 4

Related medicine news :

1. FDA Panel Rejects Avastin for Breast Cancer
2. Cancer Drug Avastin Makes Inroads Against Ovarian Tumors
3. NIH study finds Avastin and Lucentis are equally effective in treating AMD
4. More Evidence Cancer Drug Avastin May Cause Harm
5. More Evidence Links Avastin to Heart Failure in Breast Cancer Patients
6. FDA Advises Against Avastin as Treatment for Breast Cancer
7. FDA Advisers Say Avastin Shouldnt Be Used for Breast Cancer
8. Avastin Largely Safe for Patients With Type of Advanced Lung Cancer
9. Romantic Rejection May Hurt Just Like Physical Pain
10. Gift-Giving, for Many Men, Means Avoiding Rejection
11. UCLA team uncovers mechanism behind organ transplant rejection
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... 22, 2015 Liberty University has received accreditation ... program from the Council for Accreditation of Counseling & ... Liberty’s Center for Counseling & Family Studies , is ... the university’s new School of Behavioral Sciences. Prior to the ...
(Date:1/22/2015)... Woodloch Pines, an all-inclusive family resort located in ... number one best large hotel for families in the United ... annual Travelers’ Choice Awards. , TripAdvisor represents the world’s ... to millions of unbiased and honest traveler reviews. The best ...
(Date:1/22/2015)... is a seasoned and trusted leader who consistently delivers trendy ... have it lead the wedding dress industry into the future. ... for the global market. , “The CEO of VogueQueen is ... on continuing the goal of operational excellence and giving back ...
(Date:1/22/2015)... January 22, 2015 Blue Cross and Blue ... who exemplify what it means to “Live Fearless.” ... people to share their stories about how they or someone ... inspired others by living in the moment. By telling these ...
(Date:1/22/2015)... Juvent Sports ( http://www.juventsports.com ) and David Leadbetter ... to bestow a Juvent Sports Achievement award upon an ... The award commemorated and congratulated McKitrick for her record ... her first amateur tournament in 1979 and most recently ...
Breaking Medicine News(10 mins):Health News:Liberty University's Resident Master’s Counseling Program Receives CACREP Accreditation 2Health News:TripAdvisor Names Woodloch Pines Best Hotel for Families in America 2Health News:TripAdvisor Names Woodloch Pines Best Hotel for Families in America 3Health News:VogueQueen Unveils New Designs of Prom Dresses for 2015 2Health News:Blue Cross and Blue Shield of Minnesota to Showcase “Faces of Fearless” 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 3
... of America (GSA) invites all journalists to attend its ... interdisciplinary conference in the field of aging from November ... free of charge. An estimated 3,500 professionals are expected ... and Atlanta Marriott Marquis . The theme for ...
... 10, 2009) The University of Miami School of Nursing and ... T. Macdonald Foundation in the amount of $30,000 to support ... of Nursing program. "Family nurse practitioners have a promising future" ... and Health Studies. "The Dr. John T. Macdonald Foundation grant ...
... , , , LAKE FOREST, ... a leading global specialty pharmaceutical and medication delivery company, today announced ... Chicago on Thursday, Sept. 17, 2009. The company,s senior leadership team ... , , A streaming audio webcast of the ...
... , , SALT ... implant and instrument company focused on unique silicon nitride ceramic technologies, ... sq. ft. global headquarters. , , Bucking the ... need for the new larger multifunctional facility. Amedica believes the ...
... , , MUMBAI, India and PRAGUE, ... with a base in India, US, Europe and Israel today announced ... , , "Czech Republic has an excellent resource ... Strategic Operations, Europe. "Our new office in Czech Republic will further ...
... BOSTON, Sept. 10 Purchasers of pharmaceutical drugs ... of benchmark prices of some of the most common prescription ... approval of a settlement with two leading drug-pricing publishers, First ... Inc. , , (Logo: http://www.newscom.com/cgi-bin/prnh/20080317/AQM144LOGO ) ...
Cached Medicine News:Health News:An invitation to the nation's premier aging conference 2Health News:UM receives grant to support graduate students in the family nurse practitioner program 2Health News:Hospira to Host 2009 Investor Day 2Health News:Amedica Announces New Global Headquarters 2Health News:SIRO Clinpharm Expands Operations in Europe 2Health News:Major Rollback of Pharmaceutical Bench Mark Prices Approved by Federal Court of Appeals, Hagens Berman Announces 2Health News:Major Rollback of Pharmaceutical Bench Mark Prices Approved by Federal Court of Appeals, Hagens Berman Announces 3Health News:Major Rollback of Pharmaceutical Bench Mark Prices Approved by Federal Court of Appeals, Hagens Berman Announces 4
(Date:1/23/2015)... BIRMINGHAM, Ala. , Jan. 23, 2015 Gem ... (STS) patients have been enrolled into the Company,s Phase ... efficacy and safety of Gem,s lead compound, GPX-150 (an ... for advanced or metastatic disease. Logo - ...
(Date:1/22/2015)... 2015  BiOptix is pleased to announce the appointment of ... Chemistry and Biochemistry. Scott joins the company after previous scientific ... throughout the course of his nearly 20 year career ... a nationally recognized thought leader in the biosensor field ...
(Date:1/22/2015)... 22, 2015  Amgen (NASDAQ: AMGN ) today announced that ... results on Tuesday, Jan. 27, 2015, after the close of the ... call with the investment community at 2 p.m. PT. Participating in ... chairman and chief executive officer, and other members of Amgen,s senior ...
Breaking Medicine Technology:Gem Pharmaceuticals Announces Enrollment of Initial Patients in its Phase 2 Clinical Trial to Assess the Efficacy and Safety of GPX-150 in Sarcoma Patients 2BiOptix Expands Leadership Team with the Appointment of Dr. Scott Klakamp as Vice President of Chemistry and Biochemistry 2Amgen Announces Webcast of 2014 Fourth Quarter and Full Year Financial Results 2
... ,France: +33(0)1-70-99-42-73 ,U.K.: +44(0)20-7136-2052 ,USA: +1-212-444-0481 ,The dial-in ... webcast and presentation, log onto: http://www.sartorius.com ... 2011    Publication of the nine-month figures (January ... contains statements about the future development of the ...
... 25, 2011 /PRNewswire-Asia/ -- The whole healthcare market is ... and social economic increases. Generally speaking, several changes can ... of world population especially the aging population , ... in both developed and developing countries. They urgently require ...
Cached Medicine Technology:Successful First Half of 2011: Sartorius Raises Full-year Guidance 2Avoid Illness Through Easy Daily Check 2
AHFS Patient Drug Information gives you a single source for providing important information and instructions for patients on dosing, precautions, possible side effects and interactions, and more....
Containing more than 600 full drug monographs, plus abbreviated monographs for combination drugs, orphan drugs and AIDS drugs in development, A to Z Drug Facts provides up-to-date information on more...
Provides instant access to reliable information on herbs, minerals, vitamins, amino acids, probiotics, enzymes, over-the-counter hormones, and other dietary supplements commonly used by consumers....
Updated for 2006 with more than 800 complete drug entries, this mobile reference provides instant access to all the drug information nurses need in day-to-day practice....
Medicine Products: