Navigation Links
A new cancer vaccine starves tumors of blood
Date:5/24/2010

A DNA-vaccine that restricts the supply of blood to tumours has been developed by scientists at the Swedish medical university Karolinska Institutet. The vaccine slows the growth of breast cancer tumours in mice.

If a cancer tumour is to become larger than a few millimetres it must be able to stimulate the formation of new blood vessels, in order to secure the supply of oxygen and nutrients. Drugs that prevent the growth of blood vessels are thus a potential treatment alternative for tumours.

A protein known as "Delta-like ligand 4" (DLL4) has recently been identified as an important component in regulating the formation of new blood vessels. When a new blood vessel starts to grow from an existing vessel, DLL4 is expressed in the tip cells at the end of the new vessel sprout, and prevents neighbouring cells from forming new vessels. If the expression of DLL4 is blocked in a tumour, there is a large increase in the formation of new, but non-functional, blood vessels, and this leads to the tumour growing more slowly.

A research group at Karolinska Institutet has developed a DNA-vaccine against DLL4 and the blood vessel tip cells. They have shown that vaccination against DLL4 causes an immunological antibody response to DLL4, and this hinders the growth of breast cancer in mice. Tumours from vaccinated mice had a tightly packed network of non-functional blood vessels, and poor blood supply. The vaccination did not cause any undesired effects and did not affect the animal's capacity for wound healing.

"We have worked with breast cancer tumours since they often express high levels of DLL4, while normal breast tissue does not. We hope that it will be possible to use this vaccine to prevent recurrence of breast cancer after surgical treatment", says Kristian Pietras, who has led the study.

DNA-vaccination is a new method of vaccination against both cancer and infectious diseases. DNA-vaccination involves the injection of
'/>"/>

Contact: Katarina Sternudd
katarina.sternudd@ki.se
46-852-483-895
Karolinska Institutet
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Targeted therapy prolongs life in patients with HER2-positive breast cancer
2. New Drugs, New Combinations Fight Breast Cancer
3. Study Finds Possible Explanation for the Link Between Infertility and Breast/Ovarian Cancer Risks
4. MDS Nordions TheraSphere(R) for Unresectable Liver Cancer (HCC) Now Covered by Two Large U.S. Insurers
5. National Oncologist Group Warns: Current Health Care Reform Legislation Woefully Short In Addressing Cancer Care Crisis
6. Panel calls for reducing colorectal cancer deaths by striking down barriers to screening
7. Lung Cancer: Large Impact, Little Funding
8. Inflammation marker related to obesity is elevated in patients with pancreatic cancer
9. Prolactin blocks oncogene associated with poor prognosis in breast cancer
10. Older female cancer survivors have added health issues compared to their counterparts
11. Definitive study confirms chemo benefit in postmenopausal breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... Healthcare professionals who are looking for ... home or on-the-go via laptops, tablets or mobile ... premium Seminar-on-Demand CE courses. The new courses add ... hours of CE course offerings, allowing therapy ... such a diverse library, there’s something for everyone. ...
(Date:10/22/2014)... MA (PRWEB) October 22, 2014 ... new solutions for the treatment of bacterial infections, microbial ... Sinskey has joined its board of directors. , ... and Engineering Systems at The Massachusetts Institute of Technology, ... MIT faculty since 1968. Dr. Sinskey also holds positions ...
(Date:10/22/2014)... HealthDay Reporter TUESDAY, Oct. ... in vitro fertilization (IVF) -- the incubation of embryos in ... device inside the vagina, new research suggests. Scientists from ... an INVOcell, might sharply cut costs for pricey IVF procedures ... accessible to those who don,t live near big-city assisted reproduction ...
(Date:10/20/2014)... (PRWEB) October 20, 2014 With a ... Gov. Charlie Crist made a brief fundraising stop at ... on Thursday. , Fresh from a debate last night ... take the stage for the first seven minutes because ... former governor described the incident in one word: "weird." ...
(Date:10/20/2014)... October 20, 2014 T.E.N., a ... firm, announced today that William H. Murray, renowned ... 2014 ISE® Luminary Leadership Award winner. Presented annually, ... of an outstanding leader and industry practitioner for ... in advancing the information security industry. , Formerly ...
Breaking Medicine News(10 mins):Health News:Top Provider of Continuing Education at Home Releases 20 New Online Courses 2Health News:Akeso Biomedical Appoints Dr. Anthony J. Sinskey to Board of Directors 2Health News:Experimental Infertility Treatment Seems Effective, Cheaper 2Health News:Experimental Infertility Treatment Seems Effective, Cheaper 3Health News:Experimental Infertility Treatment Seems Effective, Cheaper 4Health News:At Crist Fundraiser, Dan Newlin Says, "No More Robert Germans," Will Seek Changes to Florida Missing Persons Law 2Health News:At Crist Fundraiser, Dan Newlin Says, "No More Robert Germans," Will Seek Changes to Florida Missing Persons Law 3Health News:Bill Murray named 2014 ISE® Luminary Leadership Award Winner 2Health News:Bill Murray named 2014 ISE® Luminary Leadership Award Winner 3Health News:Bill Murray named 2014 ISE® Luminary Leadership Award Winner 4
... days, experts say, , , THURSDAY, Jan. 3 (HealthDay News) -- ... be passed from one person to another through contact with ... U.S. health officials report. , The virus, which is common ... of vomiting and diarrhea in the United States, is often ...
... Examined, ARLINGTON HEIGHTS, Ill., Jan. 3 ... new,knowledge about the effects of silicone breast implants. ... the official,medical journal of the American Society of ... impact and health concerns of silicone,breast implants., ...
... Abbott (NYSE: ABT ),will announce its financial ... 2007, on Wednesday, Jan. 23, 2008, before the market ... live webcast of the earnings,conference call at 8 a.m. ... Abbott,s Investor Relations Web site at, http://www.abbottinvestor.com . An ...
... who,purchased or were given "home-canned" soup or other ... County, should not open the jars due,to the ... B.,Johnson said today., Consumers who obtained canned ... Department of Health, toll-free, at,877-PA-HEALTH., The state ...
... Idaho, Jan. 3 RxElite, Inc. (OTC,Bulletin Board: ... prescription drug products, announced today that a registration,statement ... stockholders,was declared effective by the Securities and Exchange ... provided for informational purposes only, and does not,represent ...
... body,s health, researchers say , , THURSDAY, Jan. 3 (HealthDay News) ... a placebo to a patient during their years of practice, ... in the study also said they believed in the power ... that can affect health, the researchers said. , A ...
Cached Medicine News:Health News:Stomach Flu Spread By Contaminated Computer Keyboards 2Health News:Stomach Flu Spread By Contaminated Computer Keyboards 3Health News:ASPS Studies Re-Evaluate Psychological Benefits and Health Concerns of Silicone Breast Implants 2Health News:Health Department Warns Consumers of Home-Canned Soup Linked to Potter County Restaurant 2Health News:RxElite Registration Statement Declared Effective by Securities and Exchange Commission 2Health News:Almost Half of Doctors Have Prescribed Placebos 2
(Date:10/22/2014)... Investor-Edge has initiated coverage on ... FOLD ), Progenics Pharmaceuticals Inc. (NASDAQ: PGNX ... Idera Pharmaceuticals Inc. (NASDAQ: IDRA ), and ... five companies can be accessed at: http://investor-edge.com/register ... Composite ended at 4,419.48, up 2.40%, the Dow Jones ...
(Date:10/22/2014)... 22, 2014   Reproductive Medicine Associates of ... the field of infertility, presents new clinical research ... The research abstract, released during the 70 th ... meeting in Honolulu, Hawaii , ... defect (SGD) pre-implantation genetic diagnosis (PGD). ...
(Date:10/22/2014)... , Oct. 22, 2014 AVACEN Medical announced ... received 510 (k) OTC clearance by the U.S. Food ... to be marketed over the Internet for: the ... spasms; and minor strains and sprains . ... AVACEN 100 (MSRP $2495) is a sophisticated medical device ...
Breaking Medicine Technology:Market Momentum on Biotech Stocks - Amicus Therapeutics, Progenics Pharma, Threshold Pharma, Idera Pharma, and Merrimack Pharma 2Market Momentum on Biotech Stocks - Amicus Therapeutics, Progenics Pharma, Threshold Pharma, Idera Pharma, and Merrimack Pharma 3Market Momentum on Biotech Stocks - Amicus Therapeutics, Progenics Pharma, Threshold Pharma, Idera Pharma, and Merrimack Pharma 4Market Momentum on Biotech Stocks - Amicus Therapeutics, Progenics Pharma, Threshold Pharma, Idera Pharma, and Merrimack Pharma 5New IVF Research Highlights Improved Genetic Screening Approach To Help Parents Have Healthier Babies 2New IVF Research Highlights Improved Genetic Screening Approach To Help Parents Have Healthier Babies 3AVACEN Medical Announces FDA Clearance of First Medical Device with Internal Game Mode 2
... The economical way to order tips. ... of 1000 tips). Also available in easy-to-open, ... pack. Bulk Packs are sealed with a ... for quick access to Gilsons Diamond Tips. ...
10 L, Bulk Recommended for 5 & 10 L pipettes. Ideal for pipetting into long, narrow tubes or deep well plates....
... The Theken eDISC is a revolutionary ... ability to assess and manage their patients. ... motion separates the eDISC from 1st and ... motions and loads of the lumbar spine, ...
This extended 10 ul combats contamination by keeping your pipettor out of 1.5 ul and 2.0 ul tubes. Utilizes MicroPoint design and 2 ul reference mark....
Medicine Products: