Navigation Links
£2million project aims to revolutionize the study of cancer cells in the lab
Date:4/22/2013

Researchers from Queen Mary, University of London have been awarded a 2.43million grant from the European Research Council (ERC) for a project which aims to revolutionise the field of cancer cell research by using bioengineering techniques to grow the first complex 3-dimensional human 'tumour microenvironment' in the laboratory.

Even at their earliest stages, human cancers are more than just malignant cells. Other cells and chemicals that normally support and protect the body are co-opted by the malignant cancer cells to actually help them grow and spread.

Research is increasingly pointing to the importance of not just targeting the malignant cancer cells but also this wider 'tumour microenvironment' for long-term cancer treatment.

In the CANBUILD project the multi-disciplinary team of scientists will be using the latest advances in tissue engineering, biomechanics, imaging and stem cell biology which they believe will make it possible to engineer, for the first time, a complex 3-dimensional human tumour in which the different cell types of the tumour microenvironment will communicate, evolve and grow in vitro (outside the body, in the laboratory).

The CANBUILD goal is to recreate the tumour microenvironment of human high-grade serious ovarian cancer, the subtype that leads to 70 per cent of all ovarian cancer deaths, but the research may have implications for several other cancers as well.

The vision is that this project will replace inadequate techniques where human cancer cells are grown in isolation on plastic surfaces. Success in the CANBUILD project may also provide better ways of testing new drugs that target the human tumour microenvironment.

Professor Fran Balkwill, from the Barts Cancer Institute, is Principal Investigator on the CANBUILD project. Professor Balkwill said: "About half the cells in a tumour are not cancer cells, but 'healthy' cells such as immune cells and fibroblasts which the cancer is somehow corrupting to help it grow and spread.

"It seems logical that the best long-term treatments will come from combining both therapies that target the cancer cells with something aimed at the wider tumour microenvironment which, while not cancerous cells themselves, are supporting the cancer's growth.

"Growing an in vitro model which contains all these types of cells will allow us to watch how the cells communicate and how the tumour grows, teaching us more about what is going on in this complex system and hopefully giving us a model we can test new drugs on."

The five-year research plan involves:

  • 'Deconstruction' of the human ovarian cancer tumour microenvironment

  • Constructing the artificial scaffold, optimising growth of different cell types, and assembling the model

  • Comparison of the model to fresh human tissue

  • Investigating the roles of individual cells

  • Testing new treatments that target the tumour microenvironment

    The ERC funding will also allow the team to communicate their research via Centre of the Cell, Queen Mary's award-winning science education centre, online resource, widening participation and outreach project.


    '/>"/>


  • Contact: Katrina Coutts
    k.coutts@qmul.ac.uk
    Queen Mary, University of London
    Source:Eurekalert

    Related medicine news :

    1. Sickle cell project named among Top 10 Clinical Research Achievements for 2012
    2. Michigan Lake Launches Aggressive Eurasian Watermilfoil Reduction Project
    3. Do-It-Yourself Projects May Boost White-Collar Males Self-Image
    4. Austin Oral Surgery Sponsors 2013 Project Graduation for Westwood High School
    5. Obama Unveils Vast Brain-Mapping Project
    6. New projects bringing health considerations into education, energy policy, and other decisions
    7. Blue Springs Ford Dealer has Donated $7,000 so Far to Publically Nominated Charities Through the Helping Others Project
    8. Center for Emotional Restructuring Announces a Published Article Suggesting the Brain Code for Learning and Memory Prior to Human Brain and Brain Activity Map Projects
    9. Public lecture at UC Riverside to address brain-mapping project
    10. Oxblue Construction Cameras Help Two Universities Embarked on Major Building Projects Boost Stakeholder Confidence and Improve Project Management
    11. EU funds research project on obesity and metabolic complications
    Post Your Comments:
    *Name:
    *Comment:
    *Email:
    (Date:5/28/2016)... ... , ... After a year and a half of planning the Multiple Pathways of Recovery ... Pathways of Recovery Conference was held May 2 -4, 2016 at the Mystic Marriott ... together to explore the many pathways individuals use to get into and sustain their recovery. ...
    (Date:5/27/2016)... ... 2016 , ... Two director-level employees of Horizon Blue Cross Blue Shield of ... 2016 honorees. The award recognizes businesswomen who excel in their fields and who ... the MLTSS (Managed Long-Term Services and Supports) Program at Horizon NJ Health and Theresa ...
    (Date:5/27/2016)... NY (PRWEB) , ... May 27, 2016 , ... This ... of a stroke, which we as a society can control and change. , As ... occurs nearly every 40 seconds within the United States. Plus, with an estimated 129,000 ...
    (Date:5/27/2016)... ... May 27, 2016 , ... Aimed ... by inspiring human interest stories, courtesy of leaders in the nursing and health ... the industry, from leading advocates and associations—namely Jones & Bartlett Learning. , Jones ...
    (Date:5/26/2016)... ... May 26, 2016 , ... Despite last week’s media reports hinting at ... company to wait until March 2017 for an interest rate increase, according to Rajeev ... of Business. , “The Federal Open Market Committee (FOMC) dot charts are of interest ...
    Breaking Medicine News(10 mins):
    (Date:5/25/2016)... CAMBRIDGE, England , May 25, 2016 /PRNewswire/ ... genomics company employing the precision of circulating tumour ... oncology, today announces the appointment of Professor ... will provide medical leadership across the clinical development ... that Inivata,s products help deliver significant improvements in ...
    (Date:5/24/2016)... 24, 2016 Cirujanos holandeses han ... a los médicos a compartir sus mejores prácticas por ... mundial. Profesionales médicos de Europa, África, Asia ... a la aplicación, que combina la transmisión en vivo ... seguro. Educación   "Imagine un médico ...
    (Date:5/24/2016)... May 24, 2016  Diana Russell suffers from a ... from the inside out.  This disease has put her ... her children and grandchildren to leave her home.  Because ... family cannot haul the wheelchair.  So if there is ... and Diana is left to wait for the bus. ...
    Breaking Medicine Technology: