Navigation Links
£2million project aims to revolutionize the study of cancer cells in the lab
Date:4/22/2013

Researchers from Queen Mary, University of London have been awarded a 2.43million grant from the European Research Council (ERC) for a project which aims to revolutionise the field of cancer cell research by using bioengineering techniques to grow the first complex 3-dimensional human 'tumour microenvironment' in the laboratory.

Even at their earliest stages, human cancers are more than just malignant cells. Other cells and chemicals that normally support and protect the body are co-opted by the malignant cancer cells to actually help them grow and spread.

Research is increasingly pointing to the importance of not just targeting the malignant cancer cells but also this wider 'tumour microenvironment' for long-term cancer treatment.

In the CANBUILD project the multi-disciplinary team of scientists will be using the latest advances in tissue engineering, biomechanics, imaging and stem cell biology which they believe will make it possible to engineer, for the first time, a complex 3-dimensional human tumour in which the different cell types of the tumour microenvironment will communicate, evolve and grow in vitro (outside the body, in the laboratory).

The CANBUILD goal is to recreate the tumour microenvironment of human high-grade serious ovarian cancer, the subtype that leads to 70 per cent of all ovarian cancer deaths, but the research may have implications for several other cancers as well.

The vision is that this project will replace inadequate techniques where human cancer cells are grown in isolation on plastic surfaces. Success in the CANBUILD project may also provide better ways of testing new drugs that target the human tumour microenvironment.

Professor Fran Balkwill, from the Barts Cancer Institute, is Principal Investigator on the CANBUILD project. Professor Balkwill said: "About half the cells in a tumour are not cancer cells, but 'healthy' cells such as immune cells and fibroblasts which the cancer is somehow corrupting to help it grow and spread.

"It seems logical that the best long-term treatments will come from combining both therapies that target the cancer cells with something aimed at the wider tumour microenvironment which, while not cancerous cells themselves, are supporting the cancer's growth.

"Growing an in vitro model which contains all these types of cells will allow us to watch how the cells communicate and how the tumour grows, teaching us more about what is going on in this complex system and hopefully giving us a model we can test new drugs on."

The five-year research plan involves:

  • 'Deconstruction' of the human ovarian cancer tumour microenvironment

  • Constructing the artificial scaffold, optimising growth of different cell types, and assembling the model

  • Comparison of the model to fresh human tissue

  • Investigating the roles of individual cells

  • Testing new treatments that target the tumour microenvironment

    The ERC funding will also allow the team to communicate their research via Centre of the Cell, Queen Mary's award-winning science education centre, online resource, widening participation and outreach project.


    '/>"/>


  • Contact: Katrina Coutts
    k.coutts@qmul.ac.uk
    Queen Mary, University of London
    Source:Eurekalert

    Related medicine news :

    1. Sickle cell project named among Top 10 Clinical Research Achievements for 2012
    2. Michigan Lake Launches Aggressive Eurasian Watermilfoil Reduction Project
    3. Do-It-Yourself Projects May Boost White-Collar Males Self-Image
    4. Austin Oral Surgery Sponsors 2013 Project Graduation for Westwood High School
    5. Obama Unveils Vast Brain-Mapping Project
    6. New projects bringing health considerations into education, energy policy, and other decisions
    7. Blue Springs Ford Dealer has Donated $7,000 so Far to Publically Nominated Charities Through the Helping Others Project
    8. Center for Emotional Restructuring Announces a Published Article Suggesting the Brain Code for Learning and Memory Prior to Human Brain and Brain Activity Map Projects
    9. Public lecture at UC Riverside to address brain-mapping project
    10. Oxblue Construction Cameras Help Two Universities Embarked on Major Building Projects Boost Stakeholder Confidence and Improve Project Management
    11. EU funds research project on obesity and metabolic complications
    Post Your Comments:
    *Name:
    *Comment:
    *Email:
    (Date:12/2/2016)... ... December 02, 2016 , ... Mediaplanet’s newest campaign, ... standing as living proof that attitude and determination can combine into the most ... spike around the holidays. This campaign will offer patients a new-found hope, by ...
    (Date:12/2/2016)... Honolulu, Hawaii (PRWEB) , ... December 02, 2016 ... ... 3, 2016 at the Hyatt Regency Waikiki Beach Resort and Spa in Honolulu, ... (CME) in the field of pain management. , The demand for supplemental ...
    (Date:12/2/2016)... California (PRWEB) , ... December 02, 2016 , ... "Pro3rd ... allow FCPX editors to create versatile lower third titles with just a few clicks ... Pro3rd Accents Volume 2 includes 30 lower third animations. Choose from various styles with ...
    (Date:12/2/2016)... , ... December 02, 2016 , ... ‘Tis the season ... of $1,000 each from the National Family Partnership and the Drug Enforcement Administration as ... decorated their homes and the 10 winning schools who decorated their campuses with this ...
    (Date:11/30/2016)... ... November 30, 2016 , ... Center For Discovery, a nationally ... of a new eating disorder treatment center location in Palm Beach Gardens, Florida.  The ... adolescents, both males and females ages 10 and older with eating disorders, including ...
    Breaking Medicine News(10 mins):
    (Date:12/2/2016)... Dec 1, 2016 Research and Markets ... Delivery in Cancer - Technologies, Markets and Companies" to their ... , , ... management of cancer The market value of drug delivery ... estimates from 2015-2025 are given according to organs involved and the ...
    (Date:12/2/2016)... Dec. 1, 2016 Around the corners of ... and each habitable land present over earth. Cancer has ... once in a life time this is because of ... until now. Given the steady increase in global cancer ... the spiraling healthcare costs of treatment, there is increasing ...
    (Date:12/2/2016)... , Dec. 2, 2016 Allergan plc (NYSE: ... additional information on its previously announced Accelerated Share Repurchase (ASR) ... ... As previously announced, the Company entered into ... which the Company will repurchase $10 billion of its ordinary ...
    Breaking Medicine Technology: