Navigation Links
£2million project aims to revolutionize the study of cancer cells in the lab
Date:4/22/2013

Researchers from Queen Mary, University of London have been awarded a 2.43million grant from the European Research Council (ERC) for a project which aims to revolutionise the field of cancer cell research by using bioengineering techniques to grow the first complex 3-dimensional human 'tumour microenvironment' in the laboratory.

Even at their earliest stages, human cancers are more than just malignant cells. Other cells and chemicals that normally support and protect the body are co-opted by the malignant cancer cells to actually help them grow and spread.

Research is increasingly pointing to the importance of not just targeting the malignant cancer cells but also this wider 'tumour microenvironment' for long-term cancer treatment.

In the CANBUILD project the multi-disciplinary team of scientists will be using the latest advances in tissue engineering, biomechanics, imaging and stem cell biology which they believe will make it possible to engineer, for the first time, a complex 3-dimensional human tumour in which the different cell types of the tumour microenvironment will communicate, evolve and grow in vitro (outside the body, in the laboratory).

The CANBUILD goal is to recreate the tumour microenvironment of human high-grade serious ovarian cancer, the subtype that leads to 70 per cent of all ovarian cancer deaths, but the research may have implications for several other cancers as well.

The vision is that this project will replace inadequate techniques where human cancer cells are grown in isolation on plastic surfaces. Success in the CANBUILD project may also provide better ways of testing new drugs that target the human tumour microenvironment.

Professor Fran Balkwill, from the Barts Cancer Institute, is Principal Investigator on the CANBUILD project. Professor Balkwill said: "About half the cells in a tumour are not cancer cells, but 'healthy' cells such as immune cells and fibroblasts which the cance
'/>"/>

Contact: Katrina Coutts
k.coutts@qmul.ac.uk
Queen Mary, University of London
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Sickle cell project named among Top 10 Clinical Research Achievements for 2012
2. Michigan Lake Launches Aggressive Eurasian Watermilfoil Reduction Project
3. Do-It-Yourself Projects May Boost White-Collar Males Self-Image
4. Austin Oral Surgery Sponsors 2013 Project Graduation for Westwood High School
5. Obama Unveils Vast Brain-Mapping Project
6. New projects bringing health considerations into education, energy policy, and other decisions
7. Blue Springs Ford Dealer has Donated $7,000 so Far to Publically Nominated Charities Through the Helping Others Project
8. Center for Emotional Restructuring Announces a Published Article Suggesting the Brain Code for Learning and Memory Prior to Human Brain and Brain Activity Map Projects
9. Public lecture at UC Riverside to address brain-mapping project
10. Oxblue Construction Cameras Help Two Universities Embarked on Major Building Projects Boost Stakeholder Confidence and Improve Project Management
11. EU funds research project on obesity and metabolic complications
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... genes are switched on or off plays a key ... metabolism, UT Southwestern Medical Center researchers have found., The ... obesity and diabetes, since the transcription factor involved ... influence the body,s sensitivity to insulin and leptin signaling. ... regulation of food intake and sugar disposal, and obesity ...
(Date:7/25/2014)... Innerspire, LLC ( http://www.innerspire.com ) announced ... a Creative Enrollment Specialist. In this role, Greg will ... well as his accomplished design skills to further develop ... to service the creative marketing needs of ... with small business owners and individuals looking to accelerate ...
(Date:7/25/2014)... 2014 The American Brain Tumor Association ... “ABTA CommYOUnity™” during its annual patient and family conference ... the brain tumor community as we – the first ... support services and funding brain tumor research – extend ... brain tumor awareness and getting our materials and services ...
(Date:7/25/2014)... 25, 2014 There are 700,000 people in ... each day. Though when someone hears the words, “you have ... unsure of the next step and where to turn. , ... out that next step by providing and pursuing the answers ... Brian Olson, member of the ABTA’s Board of Directors and ...
(Date:7/25/2014)... July 25, 2014 Progress in understanding ... a new era of promising brain tumor treatments, according ... School, director of the Center for Neuro-Oncology, Dana-Farber Cancer ... annual Patient and Family Conference in Chicago, July 25-26, ... and new technology are impacting the development of new ...
Breaking Medicine News(10 mins):Health News:Manipulating key protein in the brain holds potential against obesity and diabetes 2Health News:Innerspire, LLC Continues National Expansion 2Health News:Innerspire, LLC Continues National Expansion 3Health News:Innerspire, LLC Continues National Expansion 4Health News:American Brain Tumor Association Unveils Brand Identity for Newly Launched Volunteer Network 2Health News:American Brain Tumor Association Unveils Brand Identity for Newly Launched Volunteer Network 3Health News:American Brain Tumor Association Board of Directors Member Shares Story of Brain Tumor Survivorship 2Health News:American Brain Tumor Association Board of Directors Member Shares Story of Brain Tumor Survivorship 3Health News:Immunotherapy, Targeted Molecular Therapies Among Promising New Treatments for Brain Tumors 2Health News:Immunotherapy, Targeted Molecular Therapies Among Promising New Treatments for Brain Tumors 3Health News:Immunotherapy, Targeted Molecular Therapies Among Promising New Treatments for Brain Tumors 4
... a small amount of chocolate had lower risks of heart ... Failure , a journal of the American Heart Association. The ... looked at the relationship of the amount of high-quality chocolate ... The quality of chocolate consumed by the women had a ...
... they detect and treat drug-resistant staph infections, but most ... University of Illinois at Chicago. Researchers sent a ... in the U.S. to learn of their policies and ... All of the hospitals are members of Broadlane, a ...
... cells that are vital for airway repair in the lung ... are associated with a poor prognosis in patients who develop ... Jonsson Comprehensive Cancer Center have found. These adult stem ... are found in pre-cancerous areas, suggesting that these cells may ...
... has examined how a specialized Iyengar yoga program for women ... treatment, makes a difference in their recovery. For two ... a questionnaire about their physical and mental health at the ... at the end. After analyzing the data that was collected ...
... University Massey Cancer Center researchers have uncovered a new ... not always cause inflammation, chronic inflammation is known to ... published in the June issue of Nature , ... Ph.D., and their co-authors examine how sphingosine-1-phosphate (S1P), a ...
... , MONDAY, Aug. 16 (HealthDay News) -- The ... poses a health threat to clean-up workers, fishermen and members ... have examined the area. "Clinicians should be aware of, ... and related chemicals. Symptomatic patients should be asked about occupation ...
Cached Medicine News:Health News:Moderate chocolate consumption linked to lower risks of heart failure 2Health News:Moderate chocolate consumption linked to lower risks of heart failure 3Health News:MRSA policies differ among hospitals, study shows 2Health News:Lung stem cells vital to lung repair associated with poor cancer prognosis when found in tumor 2Health News:VCU Massey research finds new link between inflammation and cancer 2Health News:Gulf Oil Spill Still a Health Threat to Many, Researchers Report 2Health News:Gulf Oil Spill Still a Health Threat to Many, Researchers Report 3
(Date:7/25/2014)... , July 25, 2014  Acsis Inc., ... protection and serialization solutions, has recently posted an ... that addresses current and future needs for companies, ... the old supply chain model no longer work ... technology, including the growth of mobile technology, machine ...
(Date:7/25/2014)... , July 25, 2014 Research ... "Global Ophthalmic Diagnostic Devices Market 2014-2018" report ... About Ophthalmic Diagnostic Device ... used to identify a defect or deficiency in the ... with ophthalmic disorders such as presbyopia, cataracts, glaucoma, retinal ...
(Date:7/25/2014)... July 25, 2014 Leading events organizer ... returning for the seventh year to São Paulo, ... August 2014. The event will co-locate with Food Ingredients ... most comprehensive meeting point for the pharmaceutical industry. ... countries for pharmaceutical sales are now exploring the ...
Breaking Medicine Technology:Acsis Addresses Questions on the Modern Supply Chain 2Global Ophthalmic Diagnostic Devices Market 2014-2018: Key Vendors are Alcon, Carl Zeiss, Haag-Streit and Topcon 2CPhI South America 2014 Launches with Generics Showing Huge Growth 2CPhI South America 2014 Launches with Generics Showing Huge Growth 3CPhI South America 2014 Launches with Generics Showing Huge Growth 4
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: