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$9.55 million NCI grant targets the resistance of advanced prostate cancer
Date:10/11/2011

imaging, ultra-high throughput DNA sequencing, and the development of new transgenic animal models designed to mimic the changes that occur in human prostate cancer.

"The biology of prostate cancer is heterogenous and so we hope to combat it with a team whose specialties are equally so," Theodorescu says.

The three projects in the P01 program include determining how hypoxic signals alter gene expression (Theodorescu), creating new transgenic mouse models to determine how kinases cooperate to drive tumorigenesis (Paschal), and examining how micro RNAs regulate cell proliferation and prostate cancer progression (Dutta).

Members at the University of Colorado Cancer Center also include Scott Lucia, MD, professor of pathology, and Jeffry Kieft, PhD, associate professor of biochemistry and molecular genetics.

University of Virginia team members also include Anindya Dutta, MD, PhD, professor and chair of the Department of Biochemistry and Molecular Genetics; Henry Frierson, MD, professor of pathology; Mark Conway, PhD, professor of biostatistics; David Wotton, PhD, associate professor of biochemistry and molecular genetics; and Dan Gioeli, PhD, assistant professor of microbiology, immunology, and cancer biology.


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Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver
Source:Eurekalert

Page: 1 2

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