Navigation Links
$8 million NIH grant will fund multicenter clinical trial of stroke intervention drug
Date:4/22/2014

LOS ANGELES (April 22, 2014) Cedars-Sinai stroke intervention researchers have been informed that the National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health, will award an $8 million grant to fund a multicenter Phase II clinical trial of an experimental drug for stroke.

The drug, 3K3A-APC, will be used in combination with recombinant tissue plasminogen activator, or rtPA the "clot-busting" drug currently approved to treat ischemic strokes shortly after onset. In laboratory rodent studies, 3K3A-APC, used in combination with rtPA, had a protective effect on the lining of blood vessels, eliminating hemorrhaging, reducing brain damage, and improving animals' mobility after stroke. The new drug has completed a Phase I trial in 64 healthy volunteers to assess safety and dosing levels.

Ischemic strokes block arteries, depriving the brain of oxygen. The existing clot-buster, rtPA, may restore blood flow and often reverse the effects of a stroke if administered within three hours after symptoms begin. The drug, however, increases risk of internal bleeding in some patients, which can have brain-injuring and other harmful effects.

"Stroke is the fourth leading cause of death in the United States and a leading cause of disability, often leaving people to live out their lives with limited cognitive and physical skills. When patients receive rtPA within the three-hour time frame, the beneficial effects are often dramatic. But the drug is not without its limitations and potential side effects. Our objective in this and other studies is to spare more lives and livelihoods by making treatments more effective with fewer risks," said Patrick Lyden, MD, chair of Cedars-Sinai's Department of Neurology, director of the Stroke Program and the Carmen and Louis Warschaw Chair in Neurology.

The Phase II study will evaluate safety, tolerability and activity of 3K3A-APC when given after rtPA in patients wh
'/>"/>

Contact: Sandy Van
sandy@prpacific.com
808-526-1708
Cedars-Sinai Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. NIH awards $20 million over 5 years to train next generation of global health researchers
2. Scientist awarded $1 million grant to develop tools for hepatitis C treatment discovery
3. David H. Koch donates $10 million to Mount Sinais Jaffe Food Allergy Institute
4. $9 million grant awarded to UH to study, treat learning disabilities
5. New report shows 15 million babies born too soon every year
6. Southeast program to fight diabetes awarded nearly $10 million by HHS
7. OHSU study: Misdiagnosis of MS is costing health system millions per year
8. Enzyme corrects more than 1 million faults in DNA replication
9. 53 million Americans might have diabetes by 2025, according to a new study in Population Health Management
10. Asthma Cases Continue to Rise in U.S., Affecting Millions
11. UC San Diego Superfund Research Program receives $15 million grant renewal
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... ... July 31, 2015 , ... Ticket Down is a reliable source for authentic ... at Grant Park. The festival will end on Sunday, August 2nd. ... the annual Lollapalooza. This unique and unbelievably popular festival attracts the best in ...
(Date:7/31/2015)... ... July 31, 2015 , ... Last week, ... GoodThreads. The store can be accessed by visiting http://www.curemeso.org/store . , “Our ... customizable. The best part: whenever a product is purchased, the Meso Foundation receives ...
(Date:7/31/2015)... ... 31, 2015 , ... There’s no better way to enjoy the summer weather ... cook the next meal, making July the most appropriate to be National Hot Dog ... recipes. , Make the next cookout different than the ones in the past. Celebrate ...
(Date:7/31/2015)... ... July 31, 2015 , ... Coco Libre announced today that ... and VIPs at the 2015 Vans US Open of Surfing, July 25 through August ... claim “no added sugar” on the market, is a natural choice given the Open’s ...
(Date:7/31/2015)... ... July 31, 2015 , ... According to the article published July 27 ... Pasadena courthouse was contained and extinguished by the city’s fire department before it caused major ... at the time of the fire, and it was a fire alarm system that tipped ...
Breaking Medicine News(10 mins):Health News:Cheap 2015 Lollapalooza Tickets: Ticket Down Slashes Ticket Prices on Lollapalooza Tickets at Grant Park in Chicago for Saturday, August 1st and Sunday, August 2nd 2Health News:Mesothelioma Organization Launches New Store 2Health News:Mesothelioma Organization Launches New Store 3Health News:King Kullen Honors National Hot Dog and Blueberry Month 2Health News:King Kullen Honors National Hot Dog and Blueberry Month 3Health News:Coco Libre Brings Eco-conscious Hydration to Vans US Open of Surfing 2Health News:Article on Recent Pasadena Courtroom Fire Highlights the Effectiveness of Fire Alarm Systems, Says Fire Protection Group Inc 2Health News:Article on Recent Pasadena Courtroom Fire Highlights the Effectiveness of Fire Alarm Systems, Says Fire Protection Group Inc 3
... Encourages education and testing ... Denver (Vocus) June 25, 2009 -- Planned ... people of all ages to learn about HIV, how it is transmitted and how to get ... any of these fluids can put you at risk for HIV, which is most commonly spread ...
... FUNCTIONING TISSUE VIOLATES MEDICAL ETHICS, HUMAN RIGHTS OF BABY ... NEW YORK, June 25 Parents, pediatricians and health ... INTACT AMERICA and its website -- www.intactamerica.org ... male circumcision. The national campaign argues that painful and ...
... et al. Study Finds Dose High Enough to Cause Adverse ... Marmosets , , ARLINGTON, Va., June 25 ... evidence has emerged that phthalates may not affect the reproductive ... some rats and mice. A study by McKinnell et ...
... in French . , Montreal, June 25th ... doctors have two choices: inject them with medication to dissolve ... to open the blocked artery (primary percutaneous coronary intervention (PCI)). ... trials that do not take "real-life" conditions into account. The ...
... 28-30 in Chicago, convenes more than 2300 researchers, policymakers ... confronting the nation,s health care delivery system, including the ... state efforts to improve health care quality, reduce rising ... held at the Hilton Chicago, focuses on the need ...
... identify women with diabetes during pregnancy may be an ... population for unrecognized diabetes and prediabetes, according to Emory ... identify women with diabetes during pregnancy may be an ... population for unrecognized diabetes and prediabetes, according to Emory ...
Cached Medicine News:Health News:Planned Parenthood Recognizes National HIV Testing Day 2Health News:The Time To Rethink Male Circumcision Is Now, Group Says In Launching www.intactamerica.org 2Health News:The Time To Rethink Male Circumcision Is Now, Group Says In Launching www.intactamerica.org 3Health News:The Time To Rethink Male Circumcision Is Now, Group Says In Launching www.intactamerica.org 4Health News:New Scientific Evidence Suggests Humans Resistant to Phthalate Effect on Lab Rodents 2Health News:Research: Improving treatment of patients with heart attack 2Health News:Glucose challenge test is accurate and economical for diabetes and prediabetes screening 2Health News:Glucose challenge test is accurate and economical for diabetes and prediabetes screening 3
(Date:7/31/2015)... 2015  Xcelience, a contract development and manufacturing ... a structured cash investment in Powdersize, a ... micronization and powder size classification within the pharmaceutical ... while simultaneously adding a complete set of particle ... "As we continue to build ...
(Date:7/31/2015)... WAYNE, Pa. , July 31, 2015 /PRNewswire/ ... a fully integrated specialty pharmaceutical company focused on ... announced the closing of its previously announced underwritten ... stock at a public offering price of $11.25 ... the offering included 1,000,000 shares issued upon the ...
(Date:7/31/2015)... SAN DIEGO , July 31, 2015 ... Eisai Co., Ltd. (Headquarters: Tokyo , ... Halozyme Therapeutics, Inc. (Headquarters: San Diego, California ... , "NASDAQ: HALO") have signed a clinical collaboration agreement ... , "eribulin") in combination with Halozyme,s investigational drug PEGPH20 ...
Breaking Medicine Technology:Xcelience Makes Structured Cash Investment in Powdersize 2Xcelience Makes Structured Cash Investment in Powdersize 3Egalet Announces Closing of Public Offering of Common Stock and Exercise in Full of Underwriters' Option to Purchase Additional Shares 2Egalet Announces Closing of Public Offering of Common Stock and Exercise in Full of Underwriters' Option to Purchase Additional Shares 3Egalet Announces Closing of Public Offering of Common Stock and Exercise in Full of Underwriters' Option to Purchase Additional Shares 4Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 2Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 3Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 4Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 5Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 6
... represented by ICAP Ocean Tomo , this technology discloses an ... portfolio will be auctioned off at ICAP Ocean Tomo,s Spring ... York City. (Logo: https://photos.prnewswire.com/prnh/20100614/CG20517LOGO ) ... discloses the following: An advanced hip implant ...
... 15, 2011 Survey Sampling International (SSI)—the ... sampling solutions—has appointed Chris DeAngelis to head ... support the unique sampling requirements of health-related ... of sampling science to health-focused industries, SSI ...
Cached Medicine Technology:Healthier Healing for Hip Resurfacing - ICAP Ocean Tomo Announces Auction of an Advanced Hip Cap for Electromagnetic Tissue Stimulation by Neue Magnetodyn. 2Survey Sampling International Names Chris DeAngelis to Head New SSI Health 2Survey Sampling International Names Chris DeAngelis to Head New SSI Health 3
... Punch series facilitates fast and effective resection ... anatomically shaped meniscal rim. The flat, crescent-shaped ... access even the tightest joint spaces. Made ... 20 years of engineering experience in arthroscopy ...
... series facilitates fast and effective resection of ... shaped meniscal rim. The flat, crescent-shaped tip ... even the tightest joint spaces. Made in ... years of engineering experience in arthroscopy hand ...
... facilitates fast and effective resection of meniscal ... meniscal rim. The flat, crescent-shaped tip has ... the tightest joint spaces. Made in the ... of engineering experience in arthroscopy hand instrument ...
... WideBiter Punch series facilitates fast and effective ... smooth, anatomically shaped meniscal rim. The flat, ... to access even the tightest joint spaces. ... Inc., 20 years of engineering experience in ...
Medicine Products: