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$8.4 million grant supports health information exchange and research on Alzheimer's drugs
Date:10/11/2011

INDIANAPOLIS -- An $8.4 million American Recovery and Reinvestment Act award from the Agency for Healthcare Research and Quality is enhancing the infrastructure of the Indiana Network for Patient Care (INPC), the nation's largest and most sophisticated health information exchange.

The grant simultaneously supports a groundbreaking comparative effectiveness research study using data from the INPC to compare the benefits and harms of three drugs commonly used to treat Alzheimer's disease.

Both the infrastructure expansion, already underway, and the research study, Comparative Effectiveness Research Trial of Alzheimer's Disease Drugs (COMET-AD), which officially commences enrollment this month, will serve as national models.

The INPC enhancement will provide unique insights to regional health information exchanges and a potential national network. Results of the COMET-AD study will offer critical guidance to clinicians, patients and caretakers nationwide.

The grant is one of only 10 Prospective Outcome Systems Using Patient-specific Electronic Data to Compare Tests and Therapies (PROSPECT) awards and advances the highly regarded strengths of the Regenstrief Institute in medical informatics and aging research and the clinical pharmacology expertise of the Indiana University School of Medicine.

Patients participating in the COMET-AD study, will be randomized for treatment with donepezil (Aricept), rivastigmine (Exelon), or galantamine (Reminyl), all Food and Drug Administration- approved treatments for Alzheimer's disease. No patients will receive a placebo. The approximately 300 study participants will be patients at five memory care practices located within four central Indiana health care systems.

"The INPC contains more than 3.5 billion medical observations such as laboratory, radiology and other test results and 60 million text documents including operative notes and discharge summaries for more than 11 mill
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Contact: Cindy Fox Aisen
caisen@iupui.edu
317-274-7722
Indiana University School of Medicine
Source:Eurekalert

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