Navigation Links
$8.4 million grant supports health information exchange and research on Alzheimer's drugs
Date:10/11/2011

INDIANAPOLIS -- An $8.4 million American Recovery and Reinvestment Act award from the Agency for Healthcare Research and Quality is enhancing the infrastructure of the Indiana Network for Patient Care (INPC), the nation's largest and most sophisticated health information exchange.

The grant simultaneously supports a groundbreaking comparative effectiveness research study using data from the INPC to compare the benefits and harms of three drugs commonly used to treat Alzheimer's disease.

Both the infrastructure expansion, already underway, and the research study, Comparative Effectiveness Research Trial of Alzheimer's Disease Drugs (COMET-AD), which officially commences enrollment this month, will serve as national models.

The INPC enhancement will provide unique insights to regional health information exchanges and a potential national network. Results of the COMET-AD study will offer critical guidance to clinicians, patients and caretakers nationwide.

The grant is one of only 10 Prospective Outcome Systems Using Patient-specific Electronic Data to Compare Tests and Therapies (PROSPECT) awards and advances the highly regarded strengths of the Regenstrief Institute in medical informatics and aging research and the clinical pharmacology expertise of the Indiana University School of Medicine.

Patients participating in the COMET-AD study, will be randomized for treatment with donepezil (Aricept), rivastigmine (Exelon), or galantamine (Reminyl), all Food and Drug Administration- approved treatments for Alzheimer's disease. No patients will receive a placebo. The approximately 300 study participants will be patients at five memory care practices located within four central Indiana health care systems.

"The INPC contains more than 3.5 billion medical observations such as laboratory, radiology and other test results and 60 million text documents including operative notes and discharge summaries for more than 11 million patients. It's a robust resource for patient care and is already used for clinical outcomes and effectiveness research," said grant principal investigator Paul Dexter, M.D.

"With this support from AHRQ, we are designing and building innovative tools to capture and securely store additional critical information about patient functional status, implanted medical devices like artificial joints, and a wide range of biological data," said Dr. Dexter, who is a Regenstrief Institute investigator and associate professor of clinical medicine and of knowledge informatics and translation at the IU School of Medicine. "All this will provide insight to researchers and will help clinicians make more informed decisions for their patients and their families."

Regenstrief Institute investigator Malaz Boustani, M.D., M.P.H., associate professor of medicine at the IU School of Medicine and IU Center for Aging Research center scientist, is the principal investigator of the COMET-AD study.

"COMET-AD focuses on a very vulnerable population older adults with cognitive problems. Designing and building a health information technology infrastructure to help answer questions for this group with its many co-occurring diseases for which they take a variety of drugs, who have functional symptoms, and who often present with other issues, means we will be able to answer questions that will be relevant for all populations," said Dr. Boustani, who also is scientific director of the Indianapolis Discovery Network for Dementia.

"And the results of our study will help physicians determine which drug is better for which patient. With the vast amount of information that INPC will provide, we may determine that one drug is best for all patients or we may find that certain patients do better with one drug than another," said Dr. Boustani.


'/>"/>
Contact: Cindy Fox Aisen
caisen@iupui.edu
317-274-7722
Indiana University School of Medicine
Source:Eurekalert

Related medicine news :

1. $9.55 million NCI grant targets the resistance of advanced prostate cancer
2. Case Western Reserve receives prestigious $5.4 million grant to study esophageal cancer
3. 40 million TB deaths due to smoking over next 40 years
4. UIC awarded $14 million to study tobacco pricing and media
5. Scripps Florida scientist awarded $2.2 million grant to study hepatitis C
6. UT Southwestern, Parkland partner for $6.3 million NCI grant to improve colorectal cancer screenings
7. UMass Amherst School of Public Health wins $2.5 million training grant
8. $6.3 million center at UCSF and UC Davis seeks ways to diagnose and prevent osteoarthritis
9. Childhood asthma non-profit invests millions in health centers to help children better manage asthma
10. Penn receives $12.5 million from NIH to speed discovery to patient care
11. Campaign for Cancer Prevention connects 6 million+ members on Facebook Causes to research at BWH
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/29/2017)... ... March 29, 2017 , ... The Wall Centre Dental team ... patients from Burnaby, BC. Patients in need of experienced orthodontics, laser dentistry, porcelain ... the esteemed team at Wall Centre Dental. Drs. Parviz Roshan, Siamak Tehrani, Milton ...
(Date:3/29/2017)... ... March 29, 2017 , ... Dr. Angela Cotey, a noted general dentist ... new pediatric patients, with or without a referral. Dr. Cotey knows that interceptive ... outcome and experience. When patients receive early treatment, they may achieve straight teeth with ...
(Date:3/29/2017)... ... March 29, 2017 , ... Altima Technologies, ... diagramming network and data center assets and audio-video devices has recently updated its ... equipment shapes for free and download shapes and stencils from http://www.VisioStencils.com. ...
(Date:3/29/2017)... ... , ... HealthCareMandA.com will host an important webinar — Home Health & Hospice: ... recording of the webinar will also be made available following its live presentation. The ... are still popular targets for healthcare investors. This highly fragmented sector bounced back in ...
(Date:3/29/2017)... CA (PRWEB) , ... March 29, 2017 , ... Hamlin ... Northridge , is now offering laser dental treatments. Dental lasers are safe and effective ... dentistry expands patients’ options and can improve the overall quality of care. , Dr. ...
Breaking Medicine News(10 mins):
(Date:3/29/2017)... -- Neurim Pharmaceuticals ("Neurim") and Exeltis announced ... rights for Neurim,s new Rx PedPRM in Spain ... Neurim,s paediatric ... in children with Autism Spectrum Disorders (ASD) and neurogenetic diseases. It ... The collaboration with Exeltis will help increase the accessibility ...
(Date:3/29/2017)... 2017 /PRNewswire/ - Medicure Inc. ("Medicure") (TSXV:MPH, OTC:MCUJF), a ... the year ended December 31, 2016 after market ... are being released later than the previous fiscal ... the operations and balances of Apicore from the ... and filing date meets TSX Venture Exchange listed ...
(Date:3/29/2017)... March 29, 2017 International ... (STO: SECT B) announces that the University ... PACS in their healthcare enterprise. The Sectra solution, ... will enable access and sharing of images and ... and Sectra will enter into a development and ...
Breaking Medicine Technology: