Navigation Links
$6.75 million awarded to Case Western Reserve to study IBD
Date:12/20/2011

Investigators at Case Western Reserve University School of Medicine received a $6.75 million Program Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) to study the role of innate immunity in inflammatory bowel disease (IBD). For years, scientists have focused their attention on the role of lymphocytes and the adaptive immune system in the cause of Crohn's disease, a chronic debilitating disease affecting more than one million individuals in the United States. This grant supports the investigation of a new pathogenesis, or cause of the disease, which was discovered by Fabio Cominelli, MD, PhD, professor of medicine and pathology, chief of the division of gastrointestinal and liver disease at Case Western Reserve University School of Medicine and director of the Digestive Health Institute at University Hospitals Case Medical Center.

Dr. Cominelli and a team of investigators in the Digestive Health Research Center, using a spontaneous mouse model of ileitis, a type of Crohn's disease, discovered that the intestinal innate immune system may play a primary and critical role in causing the disease. The body's innate immune system represents the first line of general defense against harmful agents and includes infection-fighting cells. In the ileitis model, they found a deficit of these cells and as a result, harmful agents weren't being eliminated from the body. Previously, the scientific medical community thought there was a specific component triggering a reaction within the body, much like production of an antibody in response to a particular virus but rather it is a deficit in the body's natural immune system.

"We are very excited about this opportunity to study this unique mouse model of IBD and make important discoveries that can be directly applied to improve patient care and developing novel therapeutic modalities for this devastating disease. We are honored that this is the first new Program Project Grant funded by the National Institute of Diabetes and Digestive and Kidney Diseases since 2006 to study IBD," commented Dr. Cominelli, who also hold the Hermann Menges, Jr. Chair in Internal Medicine.

The team is working to develop a novel therapeutic drug target in order to manipulate the immune system. Based on the data, they hope to begin to develop a cure for Crohn's disease in five to 10 years.

The team directed by Dr. Cominelli is comprised of Derek Abbott, MD, assistant professor of pathology and Dr. Theresa Pizarro, PhD, associate professor of pathology, both at Case Western Reserve University School of Medicine, and Dr. Klaus Ley, head of the Inflammation Division at the La Jolla Institute of Allergy & Immunology in San Diego.


'/>"/>
Contact: Jessica Studeny
jessica.studeny@case.edu
216-368-4692
Case Western Reserve University
Source:Eurekalert

Related medicine news :

1. Wolfson Foundation awards £20 million to UCL for experimental neurology center
2. NYU study concludes that dentists could screen 20 million Americans for chronic physical illnesses
3. Emory and US CDC partner to continue building global public health network with $6 million grant
4. Wistar receives $4.7 million to develop drug against Epstein-Barr virus-related cancers
5. Millions of Americans Are Victims of Sexual Violence: CDC
6. Northwestern receives $10 million gift for life sciences graduates
7. RI Hospital receives $1.5 million grant to study treatments for body dysmorphic disorder
8. 2 million Californians report mental health needs; most receive little or no treatment
9. Saving millions of lives and protecting our climate through clean cooking options
10. $3.8 million grant investigates link between sleep apnea and atrial fibrillation
11. Wayne State receives $1.9 million from NIH to create novel cystic fibrosis treatments
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2017)... ... January 23, 2017 , ... The Masters of Science ... evaluation leaders with decades of experience who remain current practitioners in the field. ... system, there is a renewed demand for versatile, data-driven leadership.The American University’s MS ...
(Date:1/23/2017)... ... January 23, 2017 , ... Moisture measurement is a ... method is paramount to success. Selecting an inappropriate measurement method can cause costly ... use the same equipment. Rare or expensive substances are wasted and production may ...
(Date:1/23/2017)... ... January 23, 2017 , ... Gynecology Associates of ... gynecological services for women of all ages. The staff of Gynecology ... of reproductive services from routine health screenings to diagnosing and treating female concerns ...
(Date:1/23/2017)... ... ... “Some Infallible Characteristics of Christ”: a fascinating and entrancing novel exploring the ... of published author, Rev. Dr. Robert W. Thomas, the third of seven siblings. He ... nineteen, a pastor for over fifteen years. He is a graduate of N.C. College ...
(Date:1/22/2017)... ... January 22, 2017 , ... Medical lab testing through hospitals and ... a simple test will take days to arrive to the end customer, having to ... access to their lab tests, bypassing the cost and delay of traditional means. Now ...
Breaking Medicine News(10 mins):
(Date:1/23/2017)... Jan 23, 2017 Research and Markets has announced ... Trends - Product - Forecast to 2025" report to their offering. ... Report Highlights: ... market trends to identify the investment opportunities Market forecasts ... Key market trends across the business segments, Regions and Countries ...
(Date:1/23/2017)... Jan. 23, 2017  Using Astute Medical,s ... risk for acute kidney injury (AKI) after open-heart ... care guidelines significantly improved outcomes by ... more than 33 percent, according to a ... Intensive Care Medicine. Experience ...
(Date:1/23/2017)... January 23, 2017 Ahead of today,s trading ... how they have fared at the close: Kite Pharma Inc. (NASDAQ: ... OVAS ), and Regeneron Pharmaceuticals Inc. (NASDAQ: ... were relative laggards on Friday, January 20 th , 2017, down ... research reports on these stocks now at: ...
Breaking Medicine Technology: