$6.37 million from National Institutes of Health to find new ways to treat... (processes that result in the production ...)

$6.37 million from National Institutes of Health to find new ways to treat psoriasis

Date:11/6/2007

processes that result in the production of T-cells. Approximately 50 patients a year will participate in this area of the study.

The research team hypothesizes that S100A8/9 is associated with a molecular pattern that recruits, activates and differentiates macrophage cells in the skin of patients with psoriasis and that blocking these processes will halt the progression of the disease.

PROJECT THREE: Through a study of genetically engineered mice with disease characteristics of psoriasis, the researchers hope to analyze the biochemical processes that create the signals leading to the disease and formulate strategies to block the signals. They also hope to study the cardiovascular risks associated with this disease in this mouse model.

Case Western Reserve and UHCMC are recognized as leaders in the study of psoriasis in multiple ways; the Skin Disease Research Center, which is one of only six NIH/NIAMS centers throughout the entire country; the Murdough Family Center for Psoriasis; NIH NIAMS research project funding; Veterans Administration translational clinical trial funding; and now the Psoriasis CORT.

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Contact: Susan Griffith
susan.griffith@case.edu
216-368-1004
Case Western Reserve University
Source:Eurekalert

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