Navigation Links
$6.37 million from National Institutes of Health to find new ways to treat psoriasis
Date:11/6/2007

The National Institute of Arthritis and Musculoskeletal Skin Diseases (NIAMS), a research center at the National Institutes of Health (NIH), has awarded Case Western Reserve University School of Medicine and University Hospitals Case Medical Center a $6.37 million award to establish a Center of Research Translation (CORT) for the skin disease psoriasis.

This is one of the largest grants ever given to a medical institution in the United States for the study of psoriasis.

With a five-year grant from NIAMS, the Psoriasis CORT will bring a multidisciplinary team of translational physicians scientists, nurses, community clinicians, laity and basic scientists from different departments and disciplines together. This team will apply the intellectual and scientific resources of their institutions to new therapies to provide relief to patients with the skin disease that has long-term health and psychosocial consequences.

Our goal is to find ways to rebalance the human bodys immune system and skin cells to restrain the expression of this skin disease, said Kevin Cooper, M.D., department chair of dermatology at University Hospitals Case Medical Center (UHCMC) and professor of dermatology at the Case Western Reserve University School of Medicine. It is very important to obtain safe and durable remissions from disease because psoriasis has significant impact on patient health, spanning psychosocial effects, and risk for long-term cardiovascular complications and cancers.

The CORT grant complements a $5 million gift to University Hospitals Case Medical Center (UHCMC) from The Murdough Foundation that was received in December 2006 designed to advance the research and treatment of psoriasis. The gift remains the largest known in the United States for dermatology at an academic medical center. The Murdough Family Center for Psoriasis supports and stimulates clinical research and treatment for, and education about, psoriasis and creates a critical base for the CORT research projects and cores.

Together with the recently awarded $64 million NIH Clinical Translational Services Award to Case Western Reserve University and the NIH NIAMS Skin Diseases Research Center at Case Medical Center, the Psoriasis CORT concentrates a remarkable array of interactive research resources that we expect to change patient care with safer and better therapies, said Pamela Davis, dean of the Case Western Reserve University School of Medicine.

This CORT award reinforces University Hospitals Case Medical Centers dedication to, and progress with both the treatment and research of psoriasis, said Fred C. Rothstein, M.D., president and CEO of University Hospitals Case Medical Center. Our unique interdisciplinary approach to psoriasis therapy and study places us at the forefront of eventually curing this debilitating disease.

The NIAMS grant will allow research teams to focus on three projects that simultaneously utilize different strategies to study the disease.

  • PROJECT ONE: Researchers will test and explore the potential use in psoriasis of PC4, a novel photodynamic therapy (PDT), developed as a treatment for skin cancer at Case Western Reserve University by Malcolm Kenney, Ph.D., from the department of chemistry; Nancy Oleinick, Ph.D; and Drs. Cooper and Elma Baron at UHCMC.

    In a clinical trial, the non-invasive photosensitizer PC4 will be applied topically and exposed to red light to active the light-sensitive chemicals. After treatment, a real-time analysis of the psoriasis tissue will take place with the aid of a newly built device to conduct optical monitoring of tissue oxygen levels during treatments. The goal is to control inflammation that eventually brings on T-cell damage.

  • PROJECT TWO: Another focus of the Psoriasis CORT is to understand the role that S100A8/9, a pro-inflammatory protein, has in initiating the biochemical processes that result in the production of T-cells. Approximately 50 patients a year will participate in this area of the study.

    The research team hypothesizes that S100A8/9 is associated with a molecular pattern that recruits, activates and differentiates macrophage cells in the skin of patients with psoriasis and that blocking these processes will halt the progression of the disease.

  • PROJECT THREE: Through a study of genetically engineered mice with disease characteristics of psoriasis, the researchers hope to analyze the biochemical processes that create the signals leading to the disease and formulate strategies to block the signals. They also hope to study the cardiovascular risks associated with this disease in this mouse model.

Case Western Reserve and UHCMC are recognized as leaders in the study of psoriasis in multiple ways; the Skin Disease Research Center, which is one of only six NIH/NIAMS centers throughout the entire country; the Murdough Family Center for Psoriasis; NIH NIAMS research project funding; Veterans Administration translational clinical trial funding; and now the Psoriasis CORT.


'/>"/>

Contact: Susan Griffith
susan.griffith@case.edu
216-368-1004
Case Western Reserve University
Source:Eurekalert

Related medicine news :

1. HHS Announces $75 Million in Supplemental Funding to States for Pandemic Flu Preparedness
2. AUDIO from Medialink and Pfizer: Number of Uninsured Americans Grows to 47 Million
3. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
4. 1.5 million children could be saved
5. The Philadelphia Walk Now for Autism Expected to Draw 10,000 Walkers and Raise $1 Million to Help Find Answers About the Nations Fastest-Growing Developmental Disorder
6. UVa researcher awarded $3.6 million grant to fight drug-resistant bacteria
7. EaglePicher Corporation Completes Transaction to Sell EaglePicher Boron, LLC to Ceradyne, Inc. for $69 Million
8. R. P. Simmons Family Foundation Pledges $2 Million for New Childrens Hospital of Pittsburgh of UPMC Campus
9. £5 million investment in personalized medicines to cut patient deaths
10. Keane Wins $1 Million Electronic Medical Record (EMR) Implementation at New Jersey-Based Acute Care Facility
11. PainCare Receives $14.4 Million in Cash From Completed Sale of South Florida Ambulatory Surgery Centers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/18/2017)... ... August 18, 2017 , ... ... services to communities in east Texas, is launching a regional charity effort to ... Founded in 1991, the Pediatric Brain Tumor Foundation (PBTF) has raised nearly $30 ...
(Date:8/18/2017)... Bedford, TX (PRWEB) , ... August 18, 2017 , ... ... serves communities in the Dallas/Fort Worth area, is spearheading a regional charity campaign organized ... her husband. , In early June of this year, Christina and her children returned ...
(Date:8/18/2017)... ... 2017 , ... Alcovit, a lime-flavored beverage that rids the body of toxins ... product now available through Jet.com. , After 25 years of development, the company ... designed to quickly detox the body thereby avoiding alcohol-induced hangovers. Whether you’re having fun ...
(Date:8/18/2017)... , ... August 18, 2017 , ... “Dangerous Inheritance”: a ... author, Diane Winters. Diane is from Southwest Nebraska where she was raised on ... and family. The story is fictional, but the friendships and mantra of ‘neighbors ...
(Date:8/18/2017)... ... August 18, 2017 , ... Rollon Skin ... anti-aging skincare solutions, recently announced the launch of two new skincare products, ... yet effective alternative to expensive plastic surgery or in-patient cosmetic dermatological procedures. , ...
Breaking Medicine News(10 mins):
(Date:8/4/2017)... -- Agragen, LLC, a Cincinnati -based ... and aquacultural feed sectors, announces a significant step ... AGR131.  This drug is designed to trap and ... patients suffering from inflammatory conditions such as rheumatoid ... Biological pharmaceuticals currently used ...
(Date:8/2/2017)...   Marshall County Hospital in Benton, Kentucky has added ... hospital-acquired infections (HAIs). The new addition, Tru-D SmartUVC , short for "total room ultraviolet ... such as C. diff , MRSA, MERS, Ebola and more. ... Tru-D SmartUVC ... Tru-D in action in a patient room ...
(Date:8/1/2017)...   CerSci Therapeutics , a non-opioid drug development ... has received notice from the National Institute on Drug ... that it has been awarded a Direct-to-Phase II Small ... 2017 with an additional $1,000,000 to follow in 2018. ... of their lead non-opioid drug candidate CT-044 to the ...
Breaking Medicine Technology: