Navigation Links
$50 million to speed discoveries for patients
Date:11/12/2012

Washington University School of Medicine in St. Louis has received a $50 million grant to help speed the translation of scientific discoveries into improvements in human health.

The grant, from the National Institutes of Health (NIH), supports the School of Medicine's Institute of Clinical and Translational Sciences (ICTS), one of 60 such centers in the United States.

"We're working to advance clinical and translational research throughout the university," says ICTS Director Bradley A. Evanoff, MD, assistant dean for clinical and translational research. "The ICTS is not built around one specific disease or clinical specialty. We are charged with speeding the application of research findings in prevention, diagnosis and treatment across a wide spectrum of health conditions and research disciplines."

The grant is a renewal of a Clinical and Translational Science Award (CTSA), funded through the new National Center for Advancing Translational Sciences (NCATS), which is a part of the NIH.

Evanoff says the ICTS will support Washington University's strengths and, in doing so, help pursue the goals of the BioMed 21 initiative to encourage cross-disciplinary and translational research. Over the next five years, the ICTS will increasingly focus on promoting three areas likely to have a high impact: translating research in genetics and genomics into patient care; developing and evaluating new therapeutics; and improving ways to disseminate and implement research findings so they become part of regular medical practice.

According to Evanoff, Washington University has tremendous strengths in genetic and genomic research, and is beginning to apply the results of this research to patient care. Working with investigators in the departments of genetics and pathology and immunology, the ICTS established a Genomics Medicine Program to provide easier access to a wide range of new technologies. This is allowing more investigators to apply the tools and techniques of the genetic revolution to improve diagnosis and treatment of a host of conditions.

To speed development and evaluation of new therapeutics, the ICTS will collaborate with Washington University faculty and regional partners including Saint Louis University and the St. Louis College of Pharmacy to develop new drugs, biologics, medical devices and diagnostic tests.

Evanoff and his colleagues note that it sometimes can take years to incorporate research findings into usual medical practice. As such, the ICTS also supports the later stages of translational research most likely to benefit patients quickly. In particular, they will foster a close partnership with BJC HealthCare, the largest non-profit healthcare network in the Midwest.

In general, translational research is divided into four stages:

Taking a discovery made in the lab, often in animal models of disease, and evaluating it in humans for the first time.

Performing early clinical trials looking at safety and effectiveness in highly controlled conditions with a relatively small number of patients.

Conducting larger clinical trials in which the treatment is tested in normal clinical practice with a broader population of patients.

Spreading the word. Once something is known to work, the next step is to encourage its wide adoption across medical practices.

"We are supporting research and education across all stages of this translational research spectrum," Evanoff says. "We serve as a bridge between basic and clinical science, support early-stage clinical research and clinical trials, and link research findings to their applications in medical practice and public health."

Other major goals of the ICTS include providing financial support and training for new investigators in clinical and translational research, building new research support infrastructure, encouraging collaborations among faculty across disciplines, and creating pathways for investigators to find and utilize existing research resources.

"'Democratization of technology is a goal of the ICTS," Evanoff says. "By collaborating with existing resources at Washington University and our regional partners, we've enabled a broader group of investigators to gain access to cutting-edge technologies in imaging, genetics, and other important areas."

Evanoff also emphasizes that the ICTS is a regional consortium that includes important partnerships with BJC HealthCare, Barnes-Jewish Hospital, St. Louis Children's Hospital, Saint Louis University, the St. Louis College of Pharmacy, the Goldfarb School of Nursing, and the nursing schools at the University of Missouri-St. Louis and Southern Illinois University-Edwardsville.

"Together with our regional and national partners, our mission is to connect research findings to their eventual application in improving the health of the public," Evanoff says. "That's the exciting part of translational research."


'/>"/>

Contact: Julia Evangelou Strait
straitj@wustl.edu
314-286-0141
Washington University School of Medicine
Source:Eurekalert

Related medicine news :

1. MU Nursing School receives $14.8 million for project to reduce re-hospitalizations
2. Weill Cornell receives $1.5 million in Grand Challenges Explorations grants
3. RIT receives $3.2 million award from the NSF to advance female faculty
4. Millions Brace as Hurricane Sandy Slams the East Coast
5. Millions Prepare as Hurricane Sandy Starts Assault on East Coast
6. Millions May Be Taking Vitamin D Unnecessarily, Analysis Suggests
7. $3.4 million HHS grant to help UIC address shortage of Latino health providers
8. $20 million gift launches new hub for global health at UCSF
9. $1.8 million grant supports investigation of psoriasis link to cardiovascular disease
10. Systems biologist receives $2.5 million Pioneer Award for genome research
11. Scripps Research Institute receives $20 million to shed light on HIV drug resistance
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and ... explains one of the most popular and least understood books in the Holy Scriptures, ... puzzling descriptions that have baffled scholars for centuries. Many have tossed it off as ...
(Date:10/13/2017)... ... 2017 , ... Coveros, a leader in agile coaching services ... by the Center for Medicare and Medicaid Services (CMS). The Enterprise Agile Transformation ... Agile methodologies in a consistent and high value manner across CMS programs. Coveros ...
(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: ... “America On The Brink” is the creation of published author, William Nowers. ... As a WWII veteran, he spent thirty years in the Navy. Following ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent and ... apnea using cutting-edge Oventus O2Vent technology. As many as 18 million Americans ... frequent cessation in breathing. Oral appliances can offer significant relief to about 75 ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... meet the demand of today’s consumer and regulatory authorities worldwide. From Children’s to ... and tested to meet the highest standard. , These products are also: ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... , Oct. 4, 2017  South Korean-based healthcare ... CPR training aide "cprCUBE" on Kickstarter. The device will ... during cardiac arrests with better efficiency compared to the ... offers real-time feedback on efficacy of the compression for ... campaign has a goal to raise $5,000. ...
(Date:10/4/2017)... OBP Medical , a leading ... today announced regulatory approval from Brazil,s ... Nacional de Vigilância Sanitária (ANVISA)) to market ... with integrated LED light source and smoke evacuation ... of a tissue pocket or cavity during surgical ...
(Date:10/2/2017)... 2017  Eli Lilly and Company (NYSE: ... third quarter of 2017 on Tuesday, October 24, 2017. ... day with the investment community and media to further ... call will begin at 9 a.m. Eastern time. Investors, ... webcast of the conference call through a link that ...
Breaking Medicine Technology: