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$5 million awarded in Sixth Starr Cancer Consortium Grant Competition
Date:2/1/2013

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Dr. Olivier Elemento, of Weill Cornell, is the principal investigator for "Comprehensive Elucidation of the Mechanisms of Action of Anticancer Molecules." This research project will identify the mechanisms of action of anticancer molecules using a novel chemical genomic approach based on next-generation sequencing developed by the research team. The goal of the study is to improve the efficacy of anticancer molecules and advance the development of strategies to overcome drug resistance in patients. The team will examine cancer drugs whose mechanisms of action are partially characterized and will elucidate the resistance signature of each cancer drug; that is, the many ways by which cancer cells can develop resistance to the drug. These signatures will help identify strategies to improve drug efficacy and will predict which drugs can be combined to maximize efficacy and slow down the acquisition of resistance. The co-principal investigator for this study is Dr. Tarun Kapoor of Rockefeller University.

Dr. Todd Evans, of Weill Cornell, is the principal investigator for "Discovery of AID-dependent Epigenetic Mechanisms in Hematological Malignancies." Study investigations will focus on activation-induced cytidine deaminase (AID), a gene that regulates cytosine methylation patterns that may control the epigenetic landscape of hematopoietic stem/progenitor cells, and can impact cancer by regulating DNA methylation patterns. The goal of the study is to discover and target epigenetic mechanisms that contribute to hematological malignancies such as lymphoma and leukemia and identify novel therapeutic targets. The research team's preliminary data suggest AID functions as a tumor promoter in lymphoma, and as a tumor suppressor in myeloid leukemia. Co-principal investigators include Dr. Jayanta Chaudhuri and Dr. Ross Levine from Memorial Sloan-Kettering and Dr. Olivier Elemento, Dr. Ari Melnick and Dr. Rita Shaknovich from Weill Cornell.

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Contact: Lauren Woods
Law2014@med.cornell.edu
646-317-7401
Weill Cornell Medical College
Source:Eurekalert

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