Navigation Links
$5.9 million grant adds androgen receptor as a new driver and target in breast cancer
Date:10/1/2013

ot be able to drive cancer, either.

And so anti-androgen therapies have many potential uses in the treatment of breast cancer, including the following:

  • as a first-line drug against androgen receptor-positive cancers with or without additional hormonal drivers
  • as a second-line drug against tumors that have mutated away from estrogen or progesterone or HER2 dependence by adopting androgen-dependence
  • in combination with drugs that target estrogen receptors and HER2 to prevent cancer from mutating toward androgen-dependence in the first place
  • perhaps in addition to or instead of existing treatments for ER+ breast cancers, which seem susceptible to this anti-androgen therapy.

Blocking androgen receptors may even stop the growth of some triple negative breast cancers these aggressive cancers for which chemotherapy, radiation, surgery and hope have long been the only treatments.

"These uses and combinations are exactly what this grant will allow us to study," Elias says. "It is very difficult to get grants of this size in this climate and so we're absolutely honored to have the opportunity to push forward aggressively with our work. We'll be able to go back to the lab to ensure that in future clinical trials, everyone who could benefit from the drug, gets it."

In addition to the CU Cancer Center, this first clinical trial is being offered at Memorial Sloan-Kettering Cancer Center and the Karmanos Cancer Institute. Results should be available in fall 2014, and ongoing work is likely to lead to new clinical trials as well.

For now, patient Linda Griffin will take things as they come. "I've learned not to be optimistic or pessimistic," she says. "My goal is to feel good and lead a normal life. Three weeks into this trial, I feel fabulous. That's a result to me."


'/>"/>

Contact: Erika Matich
erika.matich@ucdenver.edu
303-724-1528
University of Colorado Denver
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. NIH awards $20 million over 5 years to train next generation of global health researchers
2. Scientist awarded $1 million grant to develop tools for hepatitis C treatment discovery
3. David H. Koch donates $10 million to Mount Sinais Jaffe Food Allergy Institute
4. $9 million grant awarded to UH to study, treat learning disabilities
5. New report shows 15 million babies born too soon every year
6. Southeast program to fight diabetes awarded nearly $10 million by HHS
7. OHSU study: Misdiagnosis of MS is costing health system millions per year
8. Enzyme corrects more than 1 million faults in DNA replication
9. 53 million Americans might have diabetes by 2025, according to a new study in Population Health Management
10. Asthma Cases Continue to Rise in U.S., Affecting Millions
11. UC San Diego Superfund Research Program receives $15 million grant renewal
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2014)... discovery that turns 160 years of neuroanatomy on its ... to be essential for the fast transmission of impulses ... ubiquitous as thought, according to a new work lead ... Institute (HSCI) and the University,s Department of Stem Cell ... of Harvard,s Department of Molecular and Cellular Biology. , ...
(Date:4/18/2014)... one of your worst memories? How did it make ... during a negative personal experience, such as how sad ... to emotional distress, especially when you can,t stop thinking ... up, thinking about the context of the memories, rather ... effective way to alleviate the negative effects of these ...
(Date:4/18/2014)... made a brain-related discovery that could revolutionize doctors, ... discovery opens up the possibility that environmental and/or ... brain activity that the researchers have identified as ... of Neuroscience has just published a paper ... professor of psychology and his doctoral student John ...
(Date:4/18/2014)... is available in French . ... surgical practice and regenerative medicine. A team led by ... (CNRS/ESPCI Paris Tech) and Didier Letourneur from the Laboratoire ... has just demonstrated that the principle of adhesion by ... to repair soft-tissue organs and tissues. This easy-to-use gluing ...
(Date:4/17/2014)... inflammation in benign prostate tissue was associated with ... was found even in those with low prostate-specific ... in Cancer Epidemiology, Biomarkers & Prevention , ... Research. , An analysis of prostate tissue biopsies ... of the Prostate Cancer Prevention Trial (PCPT) found ...
Breaking Medicine News(10 mins):Health News:Finding turns neuroanatomy on its head 2Health News:Finding turns neuroanatomy on its head 3Health News:New study suggests a better way to deal with bad memories 2Health News:New study suggests a better way to deal with bad memories 3Health News:Scientists discover brain's anti-distraction system 2Health News:Innovative strategy to facilitate organ repair 2Health News:Innovative strategy to facilitate organ repair 3Health News:Chronic inflammation may be linked to aggressive prostate cancer 2Health News:Chronic inflammation may be linked to aggressive prostate cancer 3
... Urges LCA-Vision Stockholders to Vote GOLDCINCINNATI, Feb. 27 ... Glass Lewis & Co., LLC, a leading independent research ... vote to retain the Company,s current Board of Directors ... of the current Directors and election of replacement Directors, ...
... United States Agency for International Development (USAID) is providing ... 15 and 16 in Columbia. Due to the ... extensive flooding in Tumaco municipality, Narino Department in Colombia, ... estimated 31,250 people.The money will be provided to humanitarian ...
... 27 Governor Edward G. Rendell ... nominations subject to Senate confirmation:State Board of Medicine ... Board of Examiners of Nursing Home Administrators , ... is committed to creating a first-rate public education ...
... But many people ignore the ,whisper, of trouble , , FRIDAY, ... having a stroke, you,d seek immediate medical attention. But what ... people who experience vague symptoms of a stroke suffer mental ... have found. , The implicit message? Don,t wait for ...
... 27 Dean Farms in New Castle, Lawrence County, ... resumed sales of raw milk on Feb. 26, Agriculture ... that has not been pasteurized. Pennsylvania farms selling raw ... milk laboratory tested due to the health risks associated ...
... track with boring tasks, study suggests, , , FRIDAY, Feb. ... paying attention when you doodle, but science says otherwise. ... subjects who doodled while listening to a recorded message had ... those who didn,t doodle. The findings were published in ...
Cached Medicine News:Health News:Glass Lewis Recommends Shareholders Support LCA-Vision Board of Directors and Reject All Three Proposals by Dissident Joffe Group 2Health News:Glass Lewis Recommends Shareholders Support LCA-Vision Board of Directors and Reject All Three Proposals by Dissident Joffe Group 3Health News:Glass Lewis Recommends Shareholders Support LCA-Vision Board of Directors and Reject All Three Proposals by Dissident Joffe Group 4Health News:Even Mild Strokes Can Do Harm 2Health News:Even Mild Strokes Can Do Harm 3Health News:Correction: Lawrence County Raw Milk Dairy Tests Negative for Campylobacter; Raw Milk Sales Resumed 2Health News:Take Note: Doodling Can Help Memory 2
(Date:1/15/2014)... , Jan. 15, 2014 Reportlinker.com announces ... available in its catalogue: ... Worldwide Analysis http://www.reportlinker.com/p01957812/Insulin-Pump-Market--Forecast-–-Worldwide-Analysis.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Medical_Equipment_and_Supply ... Insulin Pumps are ...
(Date:1/15/2014)... , Jan. 15, 2014  Zafgen, Inc., a ... needs of severely obese patients, today announced initial ... a selective inhibitor of methionine aminopeptidase 2 (MetAP2), ... form of genetic obesity.  These results showed improvements ...
(Date:1/14/2014)... The Brandeis Medical Center, led by Dr. Emmanuel Brandeis ... affordable laser tattoo removal experience with the advanced Astanza Duality laser ... high quality cosmetic services with cutting edge medical technology and offering ... California has seen a dramatic increase in the presence ...
Breaking Medicine Technology:Insulin Pump Market & Forecast - Worldwide Analysis 2Insulin Pump Market & Forecast - Worldwide Analysis 3Insulin Pump Market & Forecast - Worldwide Analysis 4Insulin Pump Market & Forecast - Worldwide Analysis 5Insulin Pump Market & Forecast - Worldwide Analysis 6Insulin Pump Market & Forecast - Worldwide Analysis 7Insulin Pump Market & Forecast - Worldwide Analysis 8Insulin Pump Market & Forecast - Worldwide Analysis 9Insulin Pump Market & Forecast - Worldwide Analysis 10Insulin Pump Market & Forecast - Worldwide Analysis 11Insulin Pump Market & Forecast - Worldwide Analysis 12Insulin Pump Market & Forecast - Worldwide Analysis 13Insulin Pump Market & Forecast - Worldwide Analysis 14Insulin Pump Market & Forecast - Worldwide Analysis 15Insulin Pump Market & Forecast - Worldwide Analysis 16Insulin Pump Market & Forecast - Worldwide Analysis 17Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 2Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 3Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 4Beverly Hills Physician Features Tattoo Removal with the Astanza Duality Laser, Offers $99 Special 2
... Four novel genes that may,significantly increase the ... have been identified by researchers at Massachusetts General,Hospital ... November 7th issue,of American Journal of Human Genetics. ... (AGP) established three years ago to identify,the full ...
... FREMONT, Calif., Oct. 29 Vermillion, Inc.,(OTC Bulletin ... with Quest,Diagnostics to extend the Strategic Alliance Agreement ... enable the companies to continue,work on the development ... The OVA1 test is intended to identify women ...
Cached Medicine Technology:Breakthrough Mapping of Alzheimer's Genome Helps ID Four New Suspect Genes 2Breakthrough Mapping of Alzheimer's Genome Helps ID Four New Suspect Genes 3Vermillion Renews Strategic Alliance Agreement With Quest Diagnostics, Inc. 2Vermillion Renews Strategic Alliance Agreement With Quest Diagnostics, Inc. 3Vermillion Renews Strategic Alliance Agreement With Quest Diagnostics, Inc. 4
... of the outstanding features of our Neomax ... Molding Technology. , This manufacturing process allows ... controls the bunching and irritation in the ... wearer. , ,Colors available: Blue, ...
... be the world's most versatile functional knee ... support, or both, Flex is equipped for ... hinges control flexion and extension and its ... being heat-moldable to accommodate changes in leg ...
... Donut is a neoprene alternative, constructed ... polyester Lycra Fabric that allows for ... provides for patellar control. Ideal for ... or irritations. Click here to view ...
... The cool version of the TROM ... range-of-motion and locking capabilities as the full ... warmer climates. The ease of use and ... a variety of protocols following major ligament ...
Medicine Products: