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$5.9 million grant adds androgen receptor as a new driver and target in breast cancer
Date:10/1/2013

ot be able to drive cancer, either.

And so anti-androgen therapies have many potential uses in the treatment of breast cancer, including the following:

  • as a first-line drug against androgen receptor-positive cancers with or without additional hormonal drivers
  • as a second-line drug against tumors that have mutated away from estrogen or progesterone or HER2 dependence by adopting androgen-dependence
  • in combination with drugs that target estrogen receptors and HER2 to prevent cancer from mutating toward androgen-dependence in the first place
  • perhaps in addition to or instead of existing treatments for ER+ breast cancers, which seem susceptible to this anti-androgen therapy.

Blocking androgen receptors may even stop the growth of some triple negative breast cancers these aggressive cancers for which chemotherapy, radiation, surgery and hope have long been the only treatments.

"These uses and combinations are exactly what this grant will allow us to study," Elias says. "It is very difficult to get grants of this size in this climate and so we're absolutely honored to have the opportunity to push forward aggressively with our work. We'll be able to go back to the lab to ensure that in future clinical trials, everyone who could benefit from the drug, gets it."

In addition to the CU Cancer Center, this first clinical trial is being offered at Memorial Sloan-Kettering Cancer Center and the Karmanos Cancer Institute. Results should be available in fall 2014, and ongoing work is likely to lead to new clinical trials as well.

For now, patient Linda Griffin will take things as they come. "I've learned not to be optimistic or pessimistic," she says. "My goal is to feel good and lead a normal life. Three weeks into this trial, I feel fabulous. That's a result to me."


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Contact: Erika Matich
erika.matich@ucdenver.edu
303-724-1528
University of Colorado Denver
Source:Eurekalert

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