Navigation Links
$5.9 million grant adds androgen receptor as a new driver and target in breast cancer
Date:10/1/2013

ting androgen receptors in these androgen receptor-positive (AR+) tumors can stop their growth in almost exactly the same way that doctors have used anti-estrogen therapies with ER+ tumors.

"Our preclinical work is extremely promising and we're just now starting to get results from studies in models of breast cancers resistant to current therapies. If this promising work leads to good clinical results, we could offer a new treatments for breast cancer patients who have previously been without further options," Richer says.

Dr. Elias's patient, Linda Griffin, puts it another way: "If this works, it'll make history," she says.

Androgen is not a new target in cancer. Androgens including testosterone have long been implicated as a driver of prostate cancer and so many drugs targeting both the body's production of androgens and cancer cells' ability to use the hormone are already approved, with even more treatments in the drug development pipeline. The current clinical trial uses the especially promising anti-androgen drug, Enzalutamide, which was FDA-approved in August 2012 for use in castration-resistant prostate cancer.

"Normally, the way these hormones work is by attaching to receptors in the cell cytoplasm, at which point the receptor draws itself and the hormone molecule inside the nucleus where it regulates many genes," Richer says. The genes turned on and off by ER, PR, HER2 or, now, androgen tell breast cancer cells to survive and reproduce beyond control. Enzalutamide makes androgen receptors unable to go into a cell's nucleus and so the message of growth never gets delivered.

"Interestingly, it seems that estrogen-positive breast cancers are susceptible to the same drug," Richer says, explaining that something about the way the signal of estrogen is transmitted inside a cell's nucleus requires the presence of androgen receptors in the nucleus, as well. Without androgen receptors in the nucleus, estrogen receptors may n
'/>"/>

Contact: Erika Matich
erika.matich@ucdenver.edu
303-724-1528
University of Colorado Denver
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. NIH awards $20 million over 5 years to train next generation of global health researchers
2. Scientist awarded $1 million grant to develop tools for hepatitis C treatment discovery
3. David H. Koch donates $10 million to Mount Sinais Jaffe Food Allergy Institute
4. $9 million grant awarded to UH to study, treat learning disabilities
5. New report shows 15 million babies born too soon every year
6. Southeast program to fight diabetes awarded nearly $10 million by HHS
7. OHSU study: Misdiagnosis of MS is costing health system millions per year
8. Enzyme corrects more than 1 million faults in DNA replication
9. 53 million Americans might have diabetes by 2025, according to a new study in Population Health Management
10. Asthma Cases Continue to Rise in U.S., Affecting Millions
11. UC San Diego Superfund Research Program receives $15 million grant renewal
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2015)... 2015 The report “CountryFocus Healthcare, ... essential source of information on and analysis of ... Germany’s increasingly elderly population and its associated disease ... In 2013, the elderly accounted for 27.1% of ... Annual Growth Rate (CAGR) of 1.2% to 29.5% ...
(Date:3/27/2015)... 27, 2015 On March 19, ... former Detroit Lions wide receiver Herman Moore, hosted ... presentation on substance abuse, treatment options and the ... attended were pastors, ministers and bishops from local ... distinguished guests. , “Our ‘Fighting Addiction Together’ luncheon ...
(Date:3/27/2015)... CA (PRWEB) March 27, 2015 SMI ... today announced it has launched the SM1120 MEMS based ... market. The microsensor profile at only 220um x ... maneuverability to reach challenging locations. With industry leading ... hour, the SM1120 provides a broad operating pressure range ...
(Date:3/27/2015)... March 27, 2015 Trail mix is the ... workout, on weekend hikes and during the game! It’s portable, ... Natural is proud to introduce a new line of specialty ... Deliciously rich and flavorful selections packed with nutritious, 100% all ... fruit and grains that add protein and fiber to your ...
(Date:3/27/2015)... Jersey (PRWEB) March 27, 2015 Airy ... has released the official music video for her debut ... , Combining live-action and abstract styling effects, the ... be viewed on YouTube, Vimeo, and assorted outlets. It ... the development of an expanding full-scale marketing strategy. The ...
Breaking Medicine News(10 mins):Health News:Germany Healthcare, Regulatory and Reimbursement Landscape Market Research Report Available at RnRMarketResearch.com 2Health News:Germany Healthcare, Regulatory and Reimbursement Landscape Market Research Report Available at RnRMarketResearch.com 3Health News:Germany Healthcare, Regulatory and Reimbursement Landscape Market Research Report Available at RnRMarketResearch.com 4Health News:LiveToBeSober.org Hosts Conference on Substance Abuse Treatment and Recovery at Ford Field 2Health News:SMI Launches Catheter Mountable Pressure Sensor 2Health News:Aurora Product, Inc. Introduces New Line of Specialty Trail Mixes 2Health News:Airy Jeanine Releases ‘’Mama’s Girl” Official Music Video 2
... can increase the risk of an acute attack of pancreatitis, but ... according to a study published online by BJS, the British ... in Sweden followed 84,601 people from 46 to 84 years of ... median of ten years. During that time 513 developed acute pancreatitis. ...
... , WEDNESDAY, Aug. 3 (HealthDay News) -- First they spread ... newly identified bacterium are infecting residents of the midwestern United ... will likely appear in other areas of the country. ... fatigue, has been identified in 25 people in Minnesota ...
... ITHACA, N.Y. U.S. physicians spend nearly $61,000 more ... related to health insurance, according to a new study ... Toronto. The study, published in the August issue ... per-physician costs in the U.S. averaged $82,975 annually, while ...
... (HealthDay News) -- Pregnant women who take ongoing, high doses ... increased risk of having babies with birth defects, the U.S. ... used to treat yeast infections of the vagina, mouth, throat, ... caused by a certain type of fungus and to prevent ...
... Jenifer Goodwin HealthDay Reporter , WEDNESDAY, Aug. ... for certain markers in the blood called "autoantibodies" is ... The blood test correctly detected Alzheimer,s disease in people ... percent accuracy, according to the researchers. The test could ...
... The Gerontological Society of America (GSA) the nation,s largest ... the National Center for Creative Aging (NCCA) have chosen Barry ... the 2011 recipient of the Gene D. Cohen Research Award ... the seminal work of Gene Cohen, MD, whose research in ...
Cached Medicine News:Health News:Drinking just 1 measure of spirits increases the risk of acute pancreatitis 2Health News:New Tick-Borne Illness Infects Midwesterners 2Health News:New Tick-Borne Illness Infects Midwesterners 3Health News:US physicians spend nearly 4 times more on health insurance costs than Canadian counterparts 2Health News:High Dose of Yeast Infection Drug Linked to Birth Defects, FDA Says 2Health News:Another Blood Test for Alzheimer's Shows Promise 2Health News:Another Blood Test for Alzheimer's Shows Promise 3Health News:Another Blood Test for Alzheimer's Shows Promise 4Health News:Bittman to receive 2011 Gene D. Cohen Award 2
(Date:3/27/2015)... , March 27, 2015   Cypher Genomics, ... announced new data showing that, compared to a ... technology provided highly equivalent interpretations of whether certain ... did so in a fraction of the time. ... for more comprehensive genetic analysis in non-invasive prenatal ...
(Date:3/27/2015)... March 27, 2015 CHINA ... of Senior Care, Rehabilitation Medicine and Healthcare, second to ... industry, will be held at Shanghai New International Expo ... February, 2015,  Implementation Suggestions on Encouraging Private Capital to ... which was jointly issued by the Ministry of Civil Affairs ...
(Date:3/27/2015)... HOLLYWOOD, Calif. , March 27, 2015 ... of life of myeloma patients while working toward prevention ... Higgins (D-NY) for introducing a federal resolution (H. ... of March 2015 as "National Multiple Myeloma Awareness Month." ... living with myeloma worldwide, and more than 110,000 new ...
Breaking Medicine Technology:New Data at ACMG Shows Cypher's Software Can Automate Interpretation of Genetic Variants to Advance Non-invasive Prenatal Testing 2New Data at ACMG Shows Cypher's Software Can Automate Interpretation of Genetic Variants to Advance Non-invasive Prenatal Testing 3CHINA AID, the 10th China International Exhibition of Senior Care, Rehabilitation Medicine and Healthcare to be held in April 2CHINA AID, the 10th China International Exhibition of Senior Care, Rehabilitation Medicine and Healthcare to be held in April 3CHINA AID, the 10th China International Exhibition of Senior Care, Rehabilitation Medicine and Healthcare to be held in April 4CHINA AID, the 10th China International Exhibition of Senior Care, Rehabilitation Medicine and Healthcare to be held in April 5CHINA AID, the 10th China International Exhibition of Senior Care, Rehabilitation Medicine and Healthcare to be held in April 6The International Myeloma Foundation (IMF) Secures the Introduction of a Federal Resolution Recognizing March 2015 as "National Multiple Myeloma Awareness Month" 2
... demonstrates dramatic,benefits of adding Diovan to conventional therapy , ... for,Diovan patients , , , BASEL,Switzerland, ... independent,Jikei Heart Study, published today in The Lancet[1], show ... produced a dramatic 39% reduction in,cardiovascular events and a ...
... - Journal of Clinical Oncology publishes first ... 27, 2007 /PRNewswire-FirstCall/ -- Human,Genome Sciences, Inc. ... to emerge demonstrating that its TRAIL receptor,antibodies, ... for use in the treatment of a ...
Cached Medicine Technology:Diovan Achieved 40% Reduction in Stroke and Cardiovascular Events,in Landmark Jikei Heart Study 2Diovan Achieved 40% Reduction in Stroke and Cardiovascular Events,in Landmark Jikei Heart Study 3Diovan Achieved 40% Reduction in Stroke and Cardiovascular Events,in Landmark Jikei Heart Study 4Diovan Achieved 40% Reduction in Stroke and Cardiovascular Events,in Landmark Jikei Heart Study 5Diovan Achieved 40% Reduction in Stroke and Cardiovascular Events,in Landmark Jikei Heart Study 6Diovan Achieved 40% Reduction in Stroke and Cardiovascular Events,in Landmark Jikei Heart Study 7Human Genome Sciences Reports Growing Evidence That Its TRAIL,Receptor Antibodies Have Significant Potential in the Treatment of,a Broad Range of Cancers 2Human Genome Sciences Reports Growing Evidence That Its TRAIL,Receptor Antibodies Have Significant Potential in the Treatment of,a Broad Range of Cancers 3Human Genome Sciences Reports Growing Evidence That Its TRAIL,Receptor Antibodies Have Significant Potential in the Treatment of,a Broad Range of Cancers 4Human Genome Sciences Reports Growing Evidence That Its TRAIL,Receptor Antibodies Have Significant Potential in the Treatment of,a Broad Range of Cancers 5
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: