$5.5 million from Gates Foundation funds major study of childhood ma... (the supplement and determine whether the...)

$5.5 million from Gates Foundation funds major study of childhood malnutrition

Date:3/31/2009

the supplement, and determine whether the collection of gut microbes and genes undergoes a change as a result of treatment," Gordon says. "If alterations in the gut community do occur with treatment, does its 'new state' persist after cessation of therapy or does it gradually revert to a state where the children are still at risk of malnutrition?"

The researchers also will analyze the gut microbes of the twins' mothers. A recent study by Gordon and his colleagues found that bacterial communities in the gut appear to be transmitted in a significant way from mothers to their offspring.

The grant to Washington University is part of a nearly $30 million initiative by the Gates Foundation to fund research into the root causes of malnutrition in the developing world. As part of this project, the Washington University investigators will join forces with scientists at the University of Virginia in Charlottesville, who will characterize the human genomes of identical and fraternal twins enrolled in this study to determine whether there are alterations in their human genes that regulate nutrient transport and processing.

The foundation is sponsoring work at eight sites in the developing world to address the root problems of malnutrition. By applying new genomic methods and computational tools for mining the massive data that emanate from the Malawi and Bangladesh sites, Gordon, Manary and their team, which also includes colleagues at the University of Colorado in Boulder, hope to develop a new understanding of the basis for malnutrition, and test their theories at other sites in the foundation's global network,

"It is a great privilege for us to conduct this research at a time when the revolution in genome sciences is allowing us to delve into the largely unexplored world of microbes that envelop our bodies," Gordon says. "We are looking forward to participating in this global effort to understand and treat a devastating disease that affec
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Contact: Caroline Arbanas
arbanasc@wustl.edu
314-286-0109
Washington University School of Medicine
Source:Eurekalert

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$5.5 million from Gates Foundation funds major study of childhood ma...(the supplement and determine whether the...),Health