Navigation Links
$450,000 sweetener in colon cancer battle
Date:4/24/2008

UK-based Association for International Cancer Research this week announced it will fund a Griffith University project led by Dr Joe Tiralongo to further develop a potential anti-cancer treatment that had shown promising results in lab tests.

The grant will enable the team to test a range of new 'designer' compounds on tumours in living cells.

Research leader Dr Joe Tiralongo of Griffith's Institute for Glycomics, Queensland said the compounds target a unique sugar, sialic acid, believed to give cancer cells their deadly ability to spread through the body.

"A significant number of studies have shown a consistent link between the amount of the sugar sialic acid on the surface of cancer cells, and the ability of that cancer to metastasise, or spread to other parts of the body," he said.

Sialic acid is found in cells throughout the body, giving, for example, saliva its characteristic stickiness, but it is abnormally expressed on cancer cells.

"It exists in much greater numbers on the surface of cancer cells. You could almost describe it as a 'glue' that helps cancer cells bond to other cells throughout the body," Dr Tiralongo said.

"We are working to tailor an 'inhibitor' that will block the mechanism that enables cancer cells to express this sugar on its surface."

"If progression can be slowed and the cancer contained to one part of the body, it becomes a lot easier to treat with surgery."

He said while colon cancer was the primary target, the team would also screen inhibitors against other aggressive cancers, including breast cancer and neuroblastoma.

"These cancers all over-express sialic acid, so in theory what works for one cancer could work for others.

Colon cancer is one of the most dangerous types of cancer and the second most common cause of death from cancer, with one in 18 Australian men and one in 26 women affected.

Australian National Health and Medical Research Council reports patients with a localized colon cancer have an 88 % chance of survival, however this drops to just seven per cent when the cancer has spread to other organs.

Association for International Cancer Research Scientific Co-ordinator Dr Mark Matfield said preventing tumours from spreading would be a new way of treating cancer by controlling it.

"It is the ability of cancer to spread around the body which makes it fatal," he said.

"It would not cure it but, in most cases it would make a cure unnecessary because a non-spreading tumour would not be a significant health problem."


'/>"/>

Contact: Jeannette Langan
j.langan@griffith.edu.au
61-755-528-654
Research Australia
Source:Eurekalert

Related medicine news :

1. Artificial sweeteners linked to weight gain
2. Study finds that competency in colonoscopy requires experience with 150 cases or more
3. USC study finds evidence of gender-related differences in development of colon cancer
4. New Drug Duo Helps Cut Colon Cancer Risk
5. New Drug Duo Helps Fight Colon Cancer
6. New Treatments Help Fight Liver, Colon Cancer
7. Colon cancer risk perception associated with screening behavior
8. Patient Navigators Boost Colon Screens in Urban Minorities
9. Apple pectin, apple juice extracts shown to have anticarcinogenic effects on colon
10. High-Risk Blacks Less Likely to Get Colonoscopies
11. Popular Colonoscopy Prep Solution May Pose Kidney Risks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... ... Marcy was in a crisis. Her son James, eight, was out of control. Prone to ... , “When something upset him, he couldn’t control his emotions,” remembers Marcy. “If there ... my other children and say he was going to kill them. If we were ...
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg Traurig, P.A. announced that ... chosen by their peers for this recognition are considered among the top 2 percent ... special honors as members of this year’s Legal Elite Hall of Fame: Miami ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, ... and the Road To Recovery® program to drive cancer patients to and from their ... to ensure the highest quality of life and ongoing independence. Getting to and ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. are sharpening their pencils ... an essay contest in which patients and their families pay tribute to a genetic ... 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. ...
(Date:6/24/2016)... York, NY (PRWEB) , ... June 24, 2016 ... ... publication Haute Living, is proud to recognize Dr. Barry M. Weintraub as a ... that “the most beautiful women in the world, and the most handsome men, ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Research ... MEMS Devices Medical Market Analysis 2016 - Forecast to 2022" ... The report contains up to date financial data ... analysis. Assessment of major trends with potential impact on the ... analysis of market segmentation which comprises of sub markets, regional ...
(Date:6/23/2016)... , June 23, 2016 , ... on Thursday, July 7, 2016 , , , , LOCATION: ... , , , , EXPERT PANELISTS:  , , , ... Senior Industry Analyst, Christi Bird; Senior Industry Analyst, Divyaa Ravishankar and ... The global pharmaceutical industry is witnessing an exceptional era. ...
(Date:6/23/2016)...  Guerbet announced today that it has been named ... . One of 12 suppliers to receive ... support of Premier members through exceptional local customer service ... to lower costs. ... outstanding customer service from Premier," says Massimo Carrara ...
Breaking Medicine Technology: