Navigation Links
$450,000 sweetener in colon cancer battle
Date:4/24/2008

UK-based Association for International Cancer Research this week announced it will fund a Griffith University project led by Dr Joe Tiralongo to further develop a potential anti-cancer treatment that had shown promising results in lab tests.

The grant will enable the team to test a range of new 'designer' compounds on tumours in living cells.

Research leader Dr Joe Tiralongo of Griffith's Institute for Glycomics, Queensland said the compounds target a unique sugar, sialic acid, believed to give cancer cells their deadly ability to spread through the body.

"A significant number of studies have shown a consistent link between the amount of the sugar sialic acid on the surface of cancer cells, and the ability of that cancer to metastasise, or spread to other parts of the body," he said.

Sialic acid is found in cells throughout the body, giving, for example, saliva its characteristic stickiness, but it is abnormally expressed on cancer cells.

"It exists in much greater numbers on the surface of cancer cells. You could almost describe it as a 'glue' that helps cancer cells bond to other cells throughout the body," Dr Tiralongo said.

"We are working to tailor an 'inhibitor' that will block the mechanism that enables cancer cells to express this sugar on its surface."

"If progression can be slowed and the cancer contained to one part of the body, it becomes a lot easier to treat with surgery."

He said while colon cancer was the primary target, the team would also screen inhibitors against other aggressive cancers, including breast cancer and neuroblastoma.

"These cancers all over-express sialic acid, so in theory what works for one cancer could work for others.

Colon cancer is one of the most dangerous types of cancer and the second most common cause of death from cancer, with one in 18 Australian men and one in 26 women affected.

Australian National Health and Medical Research Council reports patients with a localized colon cancer have an 88 % chance of survival, however this drops to just seven per cent when the cancer has spread to other organs.

Association for International Cancer Research Scientific Co-ordinator Dr Mark Matfield said preventing tumours from spreading would be a new way of treating cancer by controlling it.

"It is the ability of cancer to spread around the body which makes it fatal," he said.

"It would not cure it but, in most cases it would make a cure unnecessary because a non-spreading tumour would not be a significant health problem."


'/>"/>

Contact: Jeannette Langan
j.langan@griffith.edu.au
61-755-528-654
Research Australia
Source:Eurekalert

Related medicine news :

1. Artificial sweeteners linked to weight gain
2. Study finds that competency in colonoscopy requires experience with 150 cases or more
3. USC study finds evidence of gender-related differences in development of colon cancer
4. New Drug Duo Helps Cut Colon Cancer Risk
5. New Drug Duo Helps Fight Colon Cancer
6. New Treatments Help Fight Liver, Colon Cancer
7. Colon cancer risk perception associated with screening behavior
8. Patient Navigators Boost Colon Screens in Urban Minorities
9. Apple pectin, apple juice extracts shown to have anticarcinogenic effects on colon
10. High-Risk Blacks Less Likely to Get Colonoscopies
11. Popular Colonoscopy Prep Solution May Pose Kidney Risks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the Mountains to ... to save lost souls in the Philippines. “The Journey: From the Mountains to the ... teacher of the Bible. She has taught all ages and currently teaches a class ...
(Date:10/12/2017)... ... October 12, 2017 , ... First Healthcare Compliance (FHC), an ... showcase a range of technology and learning solutions at the 68th Annual American ... to be held October 14–18, 2017 at the Mandalay Bay Resort in Las ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest and fastest ... to open a flagship location in Covington, LA at 401 N. U.S. Highway 190, ... next to Office Depot in the Holiday Square shopping center. Its location allows it ...
(Date:10/12/2017)... , ... October 12, 2017 , ... IsoComforter, Inc. ( ... announced today the introduction of an innovative new design of the shoulder pad. ... you get maximum comfort while controlling your pain while using cold therapy. By utilizing ...
(Date:10/12/2017)... ... , ... Asante, a nationally recognized health system in southern ... home health joint venture through an agreement, effective October 1, 2017, to create ... health company with Asante, delivering clinically integrated care, for the past eight years. ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)...  Eli Lilly and Company (NYSE: LLY ... quarter of 2017 on Tuesday, October 24, 2017. Lilly ... with the investment community and media to further detail ... will begin at 9 a.m. Eastern time. Investors, media ... of the conference call through a link that will ...
(Date:9/28/2017)... 2017 Cohen Veterans Bioscience and Early Signal ... wearable and home sensors for real-time monitoring of patients ... a nonprofit organization focused on disruptive health solutions for ... analytical system to record and integrate behavioral, cognitive, physiological ... ...
(Date:9/23/2017)... Janssen Biotech, Inc. (Janssen) announced today that ... U.S. Food and Drug Administration (FDA) for the Biologics ... treatment of moderately to severely active rheumatoid arthritis (RA). ... needed to further evaluate the safety of sirukumab in ... "We are disappointed ...
Breaking Medicine Technology: