Navigation Links
$450,000 sweetener in colon cancer battle
Date:4/24/2008

UK-based Association for International Cancer Research this week announced it will fund a Griffith University project led by Dr Joe Tiralongo to further develop a potential anti-cancer treatment that had shown promising results in lab tests.

The grant will enable the team to test a range of new 'designer' compounds on tumours in living cells.

Research leader Dr Joe Tiralongo of Griffith's Institute for Glycomics, Queensland said the compounds target a unique sugar, sialic acid, believed to give cancer cells their deadly ability to spread through the body.

"A significant number of studies have shown a consistent link between the amount of the sugar sialic acid on the surface of cancer cells, and the ability of that cancer to metastasise, or spread to other parts of the body," he said.

Sialic acid is found in cells throughout the body, giving, for example, saliva its characteristic stickiness, but it is abnormally expressed on cancer cells.

"It exists in much greater numbers on the surface of cancer cells. You could almost describe it as a 'glue' that helps cancer cells bond to other cells throughout the body," Dr Tiralongo said.

"We are working to tailor an 'inhibitor' that will block the mechanism that enables cancer cells to express this sugar on its surface."

"If progression can be slowed and the cancer contained to one part of the body, it becomes a lot easier to treat with surgery."

He said while colon cancer was the primary target, the team would also screen inhibitors against other aggressive cancers, including breast cancer and neuroblastoma.

"These cancers all over-express sialic acid, so in theory what works for one cancer could work for others.

Colon cancer is one of the most dangerous types of cancer and the second most common cause of death from cancer, with one in 18 Australian men and one in 26 women affected.

Australian National Health and Medical Research Council reports patients with a localized colon cancer have an 88 % chance of survival, however this drops to just seven per cent when the cancer has spread to other organs.

Association for International Cancer Research Scientific Co-ordinator Dr Mark Matfield said preventing tumours from spreading would be a new way of treating cancer by controlling it.

"It is the ability of cancer to spread around the body which makes it fatal," he said.

"It would not cure it but, in most cases it would make a cure unnecessary because a non-spreading tumour would not be a significant health problem."


'/>"/>

Contact: Jeannette Langan
j.langan@griffith.edu.au
61-755-528-654
Research Australia
Source:Eurekalert

Related medicine news :

1. Artificial sweeteners linked to weight gain
2. Study finds that competency in colonoscopy requires experience with 150 cases or more
3. USC study finds evidence of gender-related differences in development of colon cancer
4. New Drug Duo Helps Cut Colon Cancer Risk
5. New Drug Duo Helps Fight Colon Cancer
6. New Treatments Help Fight Liver, Colon Cancer
7. Colon cancer risk perception associated with screening behavior
8. Patient Navigators Boost Colon Screens in Urban Minorities
9. Apple pectin, apple juice extracts shown to have anticarcinogenic effects on colon
10. High-Risk Blacks Less Likely to Get Colonoscopies
11. Popular Colonoscopy Prep Solution May Pose Kidney Risks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2017)... ... 30, 2017 , ... This morning, more than 275 medical ... support for an independent Vaccine Safety Commission. Five of the signers of the ... hold a press conference at 9:00 AM Friday, March 31 at the ...
(Date:3/29/2017)... ... March 29, 2017 , ... Full Contact K9, an Atlanta-based dog ... Protect Law that assists dog owners in creating legally-enforceable pet trusts for their ... the natural next step to protect their new companion. Says Evan Dunbar, CEO of ...
(Date:3/29/2017)... ... 2017 , ... Sports Brand EXOUS Bodygear announced today a special sale price ... the remaining days of March, the price will be only $19.97. The EXOUS Bodygear ... just $10 (regular retail price $19.97). , The special promotional prices are to help ...
(Date:3/29/2017)... , ... March 29, 2017 , ... ... FASTBRACES® in Carnegie, OK, from Dr. Jamie Cameron, with or without ... efficiently, compared to traditional orthodontic treatment. Depending on each patient’s case, treatment with ...
(Date:3/29/2017)... ... ... Curio Wellness , a premium medical cannabis brand and trusted healthcare ... team with prominent executives from both inside and outside the cannabis industry. , ... Dumbauld , who has more than twenty years of business leadership and investment experience ...
Breaking Medicine News(10 mins):
(Date:3/29/2017)... TOKYO , March 29, 2017  The ... unique Japanese public-private partnership formed to battle infectious ... investments totaling US$23 million* that could help deliver ... host of debilitating conditions. This ... a Phase 3 clinical trial testing a pediatric ...
(Date:3/29/2017)... leader in accelerated orthodontics, OrthoAccel ® Technologies, Inc. ... Manal Ibrahim , Kenji Ojima , Ivan ... microlecture presenters at the AcceleDent ® booth (#3037) ... Session, April 21-25, 2017. Orthodontists and their staff are ... a.m. On the opening morning of AAO exhibitions, Sat., ...
(Date:3/29/2017)... 2017 Transparency Market Research ... an exhaustive study of the U.S. substance abuse treatment ... are functional in this market at present, making ... companies, such as GlaxoSmithKline Plc., Pfizer Inc., Alkermes ... various marketing strategies to increase their visibility, the ...
Breaking Medicine Technology: