Navigation Links
$4 million award to improve detection of acute kidney injury after cardiac surgery
Date:2/14/2008

Researchers at Yale School of Medicine have received a five-year, $4 million National Institutes of Health grant to study novel ways to improve the diagnosis of acute kidney injury (AKI), a common complication of cardiac surgery that results in increased mortality.

Results from serum creatinine, the current diagnostic test for AKI, are usually normal until two to three days after cardiac surgery.

To speed the detection of AKI in cardiac surgery patients, Yale researchers, led by nephrologist Chirag Parikh, M.D., are studying three biomarkers: urine interleuken 18 (IL-18), urine neutrophil gelatinase associated lipocalin (NGAL), and serum cystatin C. Parikh and his colleagues are doing the work in conjunction with a clinical consortium called Translational Research Investigating Biomarker Endpoints in Acute Kidney Injury (TRIBE-AKI). The consortium is a multidisciplinary group of investigators from five major academic centers with expertise in pre-clinical, translational, epidemiologic and health services research.

Having new biomarkers to replace serum creatinine will allow for the early and accurate diagnosis of AKI, said Parikh, associate professor in the Department of Internal Medicine at Yale School of Medicine, section of nephrology. Findings from this study will pave the way for larger multi-center studies of these biomarkers in other clinical conditions, and for clinical trials to prevent or to treat AKI.

The consortium will study urine and serum samples, along with clinical data during hospitalization, from approximately 1,800 adults and children receiving cardiac surgery.

Parikh and colleagues will compare the timing of increases in biomarker levels with the clinical diagnosis of AKI and will look for the ability of biomarkers to give an early diagnosiswithin 24 to 48 hours. They will also test whether serum cystatin C could better predict pre-operative risk of AKI, and whether urine IL-18 and NGAL levels will be better post-operative markers of AKI occurrence and severity.


'/>"/>

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
Source:Eurekalert  

Related medicine news :

1. Newly Released 2009 COLA Forecast Would Keep Five Million Seniors Below Poverty Line
2. Phyhealth Concludes $1.5 Million Financing for Launch of Its Pilot Community-Based HMO
3. AMERIGROUP Reports Q4 Net Income of $31.1 Million or $0.57 Per Diluted Share; Full-Year Net Income of $116.5 Million or $2.16 Per Diluted Share
4. Caring Give Back A Smile Volunteer Dental Professionals Donate Over $5 Million in Services to Survivors of Domestic Violence
5. Echo Therapeutics Announces Closing of Approximately $2.3 Million Private Financing
6. LMS Third Quarter 2008 Financial Results - Q3 Revenue Increases 88% to $1.0 Million - YTD Revenue Increases 87% to $2.6 Million
7. Kaiser Permanente Approves $29 Million in Community Benefit Grants
8. Photo: Animal Rescue League of Boston Receives $3 Million Grant to Establish a Center for Shelter Dogs
9. Isis Announces Approximately $2.8 Million in Government Grants and Contracts Awarded to its Ibis Subsidiary to Advance Ibis Pathogen Identification Technology
10. 40 Million Americans Endure Anxiety Everyday
11. Varian, Inc. Board Authorizes New $100 Million Stock Repurchase Program
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
$4 million award to improve detection of acute kidney injury after cardiac surgery
(Date:1/17/2017)... York, NY (PRWEB) , ... January 17, 2017 , ... ... grand opening of a new showroom at South Dixie Hwy in Miami, FL. , ... Officer at Gym Source. “The new innovative in-store concept is designed to give clients ...
(Date:1/17/2017)... Phoenix, AZ (PRWEB) , ... January 17, 2017 ... ... new and improved supplement, Healthful-Flex. , The company, owned and operated by ... the public at a reasonable price with the highest level of customer service. ...
(Date:1/17/2017)... , ... January 17, 2017 , ... ... new 21st century approach to infusing high speed technology into the fabric of ... dedicated to the advancement of healthcare and wellness in a yet-to-be-named, health focused ...
(Date:1/17/2017)... ... 2017 , ... Peoples Health is pleased to announce that ... 1, 2016. Peoples Health, a Metairie-based Medicare Advantage company, serves more than 55,000 ... our provider network, and the addition will benefit our members in the Greater ...
(Date:1/17/2017)... ... January 17, 2017 , ... Neil H. Greco Insurance Agency, a ... communities throughout the region, is launching a charity drive to raise awareness of heart ... the deadliest killer in America, and is responsible for 1 in every 4 deaths ...
Breaking Medicine News(10 mins):
(Date:1/17/2017)...  Edwards Lifesciences Corporation (NYSE: EW ), ... disease and critical care monitoring, plans to announce its ... after the market closes on Wednesday, February 1, 2017, ... ET that day to discuss those results. ... or (201) 689-8037.  For 72 hours following the call, ...
(Date:1/17/2017)... the company that brought a full line of equine first aid ... line of companion animal pet first aid kits.  EquiMedic ... has developed two sizes of small pet first aid kits under ... Featuring a small and a large companion pet first aid kit, ... a newcomer to working with small animals either. Corporate owners, mother ...
(Date:1/17/2017)... 2017  OrthoAccel ® Technologies, Inc. announces that ... published "The Effect of Vibration on Molar Distalization," a ... S. Jay Bowman , this prospective, peer-reviewed clinical ... SoftPulse Technology ® speeds up molar distalization rates ... number of days to move the upper molars into ...
Breaking Medicine Technology: