Navigation Links
$4 million award to improve detection of acute kidney injury after cardiac surgery
Date:2/14/2008

Researchers at Yale School of Medicine have received a five-year, $4 million National Institutes of Health grant to study novel ways to improve the diagnosis of acute kidney injury (AKI), a common complication of cardiac surgery that results in increased mortality.

Results from serum creatinine, the current diagnostic test for AKI, are usually normal until two to three days after cardiac surgery.

To speed the detection of AKI in cardiac surgery patients, Yale researchers, led by nephrologist Chirag Parikh, M.D., are studying three biomarkers: urine interleuken 18 (IL-18), urine neutrophil gelatinase associated lipocalin (NGAL), and serum cystatin C. Parikh and his colleagues are doing the work in conjunction with a clinical consortium called Translational Research Investigating Biomarker Endpoints in Acute Kidney Injury (TRIBE-AKI). The consortium is a multidisciplinary group of investigators from five major academic centers with expertise in pre-clinical, translational, epidemiologic and health services research.

Having new biomarkers to replace serum creatinine will allow for the early and accurate diagnosis of AKI, said Parikh, associate professor in the Department of Internal Medicine at Yale School of Medicine, section of nephrology. Findings from this study will pave the way for larger multi-center studies of these biomarkers in other clinical conditions, and for clinical trials to prevent or to treat AKI.

The consortium will study urine and serum samples, along with clinical data during hospitalization, from approximately 1,800 adults and children receiving cardiac surgery.

Parikh and colleagues will compare the timing of increases in biomarker levels with the clinical diagnosis of AKI and will look for the ability of biomarkers to give an early diagnosiswithin 24 to 48 hours. They will also test whether serum cystatin C could better predict pre-operative risk of AKI, and whether urine IL-18 and NGAL levels will be better post-operative markers of AKI occurrence and severity.


'/>"/>

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
Source:Eurekalert  

Related medicine news :

1. Newly Released 2009 COLA Forecast Would Keep Five Million Seniors Below Poverty Line
2. Phyhealth Concludes $1.5 Million Financing for Launch of Its Pilot Community-Based HMO
3. AMERIGROUP Reports Q4 Net Income of $31.1 Million or $0.57 Per Diluted Share; Full-Year Net Income of $116.5 Million or $2.16 Per Diluted Share
4. Caring Give Back A Smile Volunteer Dental Professionals Donate Over $5 Million in Services to Survivors of Domestic Violence
5. Echo Therapeutics Announces Closing of Approximately $2.3 Million Private Financing
6. LMS Third Quarter 2008 Financial Results - Q3 Revenue Increases 88% to $1.0 Million - YTD Revenue Increases 87% to $2.6 Million
7. Kaiser Permanente Approves $29 Million in Community Benefit Grants
8. Photo: Animal Rescue League of Boston Receives $3 Million Grant to Establish a Center for Shelter Dogs
9. Isis Announces Approximately $2.8 Million in Government Grants and Contracts Awarded to its Ibis Subsidiary to Advance Ibis Pathogen Identification Technology
10. 40 Million Americans Endure Anxiety Everyday
11. Varian, Inc. Board Authorizes New $100 Million Stock Repurchase Program
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
$4 million award to improve detection of acute kidney injury after cardiac surgery
(Date:10/13/2017)... ... 13, 2017 , ... The American Board of Family Medicine's (ABFM) Board of ... Executive Officer, succeeding Dr. James C. Puffer upon his retirement. Dr. Newton will serve ... Puffer’s retirement at the end of 2018. Upon assuming the role of President and ...
(Date:10/13/2017)... ... October 13, 2017 , ... Apple Rehab Shelton Lakes , which ... evacuation of the facility as part of a disaster drill on October 3rd. , ... and Shelton City Emergency Manager, as well as the Connecticut Long Term Care ...
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and ... explains one of the most popular and least understood books in the Holy Scriptures, ... puzzling descriptions that have baffled scholars for centuries. Many have tossed it off as ...
(Date:10/12/2017)... ... October 12, 2017 , ... First ... compliance program management, will showcase a range of technology and learning solutions at ... (NCAL) Convention and Expo to be held October 14–18, 2017 at the Mandalay ...
(Date:10/12/2017)... ... ... The American College of Medical Informatics (ACMI) will present the 2017 Morris ... of AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual Symposium is taking ... in the field of medical informatics, this prestigious award is presented to an individual ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... , Oct. 10, 2017   West Pharmaceutical ... innovative solutions for injectable drug administration, today shared the ... ID Adapter for improving the intradermal administration of polio ... Skin Vaccination Summit in May 2017 by Dr. ... Polio Department, World Health Organization (WHO), and recently published ...
(Date:10/4/2017)... , Oct. 4, 2017 OBP ... self-contained, illuminating medical devices, today announced regulatory approval ... Surveillance Agency (or Agência Nacional de Vigilância Sanitária ... single-use, cordless surgical retractor with integrated LED light ... access, illumination and exposure of a tissue pocket ...
(Date:10/2/2017)... COPENHAGEN, Denmark , Oct. 2, 2017 The ... tool in the struggle to reverse the tide of prescription ... plan for regulating their medicine intake and stepping down their ... is set to launch in December 2017; the first 100,000 ... access. Learn more at http://www.rebound-solution.com/ ...
Breaking Medicine Technology: