Navigation Links
$37 million financing for company based on macular degeneration research
Date:10/9/2007

New Haven, Conn. Optherion, Inc. a company that will use groundbreaking discoveries by scientists at Yale and the University of Iowa to develop products to diagnose and treat Age-related Macular Degeneration (AMD) and other related chronic diseases has received $37 million in start-up financing.

Discoveries in 2005 by Josephine Hoh at Yale School of Public Health and Gregory Hageman at the University of Iowa linked Complement Factor H (CFH) and Complement Factor B (CFB) two elements of the alternate complement pathway of the immune system with AMD. These factors are involved in inflammatory responses, which can cause tissue damage when improperly controlled.

AMD is caused by degeneration of the macula, the region of the retina responsible for central vision. There are two forms of AMD, dry and wet. AMD is the leading cause of blindness in people over age 60 in the developed world. Dry AMD is the most common form, while wet AMD is a less prevalent and more aggressive form of the disease with growth of new blood vessels into the retina.

Optherions initial focus will be to develop disease-modifying therapies to prevent loss of vision in patients with dry AMD, as well as a portfolio of tests that predict, diagnose and monitor progression of the disease.

AMD is unusual because it is a widespread disease that is caused by common variations in only a few specific genes. Approximately 50% of patients with AMD suffer from variations in the CFH gene, and 74% of the disease can be explained by variations in the CFH and CFB genes combined. Variants in other genes, found on Chromosome 10, are also implicated in AMD, and will be a further focus for the companys development of therapeutic and diagnostic products.

In the future, the companys proprietary technologies will also be extended to the possible diagnosis and treatment of other chronic diseases related to the alternative complement system.

We are extraordin
'/>"/>

Contact: Janet Rettig Emanuel
janet.emanuel@yale.edu
203-432-2157
Yale University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Drug May Make Breathing Easier for Millions
2. Hundred million dollar gift for malaria institute
3. George Bush pledges 200 million dollars for AIDS relief
4. Hope for 11 million children facing death from illnesses
5. The forgotten epidemic killing millions
6. WHO and UNAIDS unveil plan to get 3 million AIDS patients on treatment by 2005
7. Over Six Million HIV Infected People In South Africa- Finds A Survey
8. Tanzanian Government Sanctions $20 Million For AIDS Arug
9. Grant of $7 million for Orissa Medical College from Japan
10. Merck to pay $ 253.5 million to Vioxx victim family
11. GlaxoSmithKline to Supply United States with 8 Million flu vaccine, Fluarix
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2015)... Paul, MN (PRWEB) March 27, 2015 ... annual Minnesotans for Healthy Kids Coalition Lobby Day ... the Statewide Health Improvement Program (SHIP). Everlast ... the 2015 PE Bill SF343/HF498 which would strengthen ... require annual student assessments and other measures to ...
(Date:3/27/2015)... March 27, 2015 Canadian Cannabis ... safe prescribing and utilization of medical cannabis as ... network of doctors and clinics dedicated to providing ... a trusted gateway for patients searching for medical ... territories, recently launched their sub domain for Canada. ...
(Date:3/27/2015)... Hawkins, Pastor and Overseer at The House of Yahweh in ... is through the Laws of Peace written in the Holy ... article titled, “Yahweh’s Way-The Great Difference” focuses on the past ... the original biblical instructions has caused mass chaos worldwide. ... in the world is based on man-made laws that will ...
(Date:3/26/2015)... Moreno Ranches, a top breeder of Brahman ... the 2015 International Brahman Show and Sale, held in ... categories of show cattle for sale. , “We are ... Brahman show,” explained Kelvin Moreno, head of Moreno Ranches. ... our superior genetics is in the placements across divisions ...
(Date:3/26/2015)... 26, 2015 Alliance Healthcare Foundation (AHF), ... wellness for the poor and underserved in San Diego ... its annual $1 million award, the Innovation Initiative (i2). ... the 2015 round of our Innovation Initiative Award,” AHF ... some incredibly creative and ambitious projects in the past ...
Breaking Medicine News(10 mins):Health News:Everlast Climbing Advocates to Strengthen Physical Education in Minnesota Schools 2Health News:Canadian Cannabis Clinics (CCC) to Join the Canada.MarijuanaDoctors.com Network 2Health News:The World Does Not Have to Continue in Misery, Says Yisrayl Hawkins in New Article 2Health News:Red and Gray Brahman Cattle Champions Announced by Moreno Ranches at International Brahman Show and Sale in Houston, Texas 2Health News:Applications Open for $1M Innovation Initiative Award from Alliance Healthcare Foundation 2
... have found an interesting wrinkle in the decision- making process ... differently when they rely on past experiences, rather than when ... , The research team gave people two kinds of ... a double-or-nothing win. The other choice was between a sure ...
... performed by female runners not only significantly reduced ... by runners -- but they also improved the ... expert Tracy Dierks. "The results indicate ... pain, which corresponded to improved mechanics," said Dierks, ...
... In a multicenter clinical trial, UT Southwestern ... of stereotactic radiation therapy requiring fewer treatments are ... cancer. Results of the trial, available in ... that stereotactic body radiation therapy (SBRT), which delivers ...
... June 2 (HealthDay News) -- A man,s heart disease risk after ... to his mother,s body size and placenta size when he was ... of a mother,s lifetime nutrition and the early growth of her ... epidemiology at the University of Southampton in the United Kingdom, said ...
... 2011 Children whose parents get divorced generally don,t experience ... their peersand don,t catch upwhen it comes to math and ... according to a new study. In addition, the study, ... Sociological Review , finds that children of divorce are more ...
... mothers face poorer health at midlife than do women who ... which appears in the June 2011 issue of the ... had their first child outside of marriage described their health ... This is the first U.S. study to document long-term negative ...
Cached Medicine News:Health News:ACSM: Stronger hips improved running mechanics, lessened knee pain 2Health News:Higher doses of radiation in fewer treatments proved safe, effective for low-risk prostate cancer 2Health News:Male Heart Disease May Be Linked to Mom's Lifetime Nutrition 2Health News:Study: Children of divorce lag behind peers in math and social skills 2Health News:Single moms entering midlife may lead to public health crisis 2Health News:Single moms entering midlife may lead to public health crisis 3
(Date:3/27/2015)... , March 27, 2015 Concord Medical ... (NYSE: CCM ), a leading specialty hospital ... network of radiotherapy and diagnostic imaging centers in ... signing of a purchase agreement under which Concord ... subsidiary of the Company, agreed to acquire the ...
(Date:3/27/2015)... March 27, 2015  WebMD Health Corp. ... of health information, today announced an exclusive ... National Action Plan for Combating Antibiotic-Resistant Bacteria ... the urgency and importance of addressing antibiotic-resistant ... global health.    The WebMD interview, ...
(Date:3/26/2015)... , March 26, 2015  The Burzynski Research ... study independently conducted by the Department of Surgery ... Japan have been published. The study, ... hepatic arterial infusion as post-operative adjuvant therapy with ... of the liver. A total ...
Breaking Medicine Technology:Concord Medical Announces Acquisition of Fortis Surgical Hospital in Singapore 2Concord Medical Announces Acquisition of Fortis Surgical Hospital in Singapore 3Exclusive: WebMD Interviews President Obama About Plan for Combating Antibiotic Resistance 2Exclusive: WebMD Interviews President Obama About Plan for Combating Antibiotic Resistance 3
Extremely wide blade opening. Excellent bio and MRI compatibility. Lot number on each clip. Long reliable history. Large type 1/1 (mm), opening width 6.0 mm and length 7.5 mm....
Extremely wide blade opening. Excellent bio and MRI compatibility. Lot number on each clip. Long reliable history. Large type 1/1 (mm), opening width 10.0 mm and length 10 mm....
Extremely wide blade opening. Excellent bio and MRI compatibility. Lot number on each clip. Long reliable history. Large type 1/1 (mm), opening width 8.0 mm and length 5 mm....
Extremely wide blade opening. Excellent bio and MRI compatibility. Lot number on each clip. Long reliable history. Large type 1/1 (mm), opening width 8.0 mm and length 5 mm....
Medicine Products: