Navigation Links
$3.8 million grant investigates link between sleep apnea and atrial fibrillation
Date:11/22/2011

Case Western Reserve University School of Medicine has received a $3.8 million grant from the National Heart, Lung, and Blood Institute (NHLBI) to study sleep apnea as a possible cause of atrial fibrillation (AF), the most commonly diagnosed type of arrhythmia, or irregular heart rhythm.

AF is characterized by an abnormally rapid heart rate that can inhibit blood flow, and raise the risk of stroke and heart failure. The five-year, NHLBI grant will enable researchers to study how sleep apnea, a treatable disorder in which breathing repeatedly stops and starts during sleep, produces functional and structural changes in the heart that may well contribute to the development of AF.

"The new research will characterize what aspects of sleep apnea lead to AF, honing in on the effects of sleep apnea-induced changes to the structure of the heart, including increases in blood pressure and reductions in oxygen levels," says the study's principal investigator, Reena Mehra MD, MS, associate professor of medicine in the Department of Medicine at Case Western Reserve University School of Medicine and a pulmonary, critical care and sleep medicine physician at University Hospitals Case Medical Center. "The data generated from the research will fuel the development of new approaches for prevention and treatment of AF, and, will help identify key factors for future clinical trials," she says.

More fully identifying AF risk factors and developing new treatments is instrumental to stemming the growing rate of AF, a condition that could afflict up to 16 million individuals by the year 2050, according to research projections.

The growing prevalence of AF is not fully explained by known risk factors, such as age, existing heart disease and family history, highlighting the need to more precisely identifying potential novel AF triggers, Dr. Mehra explains.

Because sleep disorders like sleep apnea are common among patients with heart disease, Dr. Mehra and her team believe that the repetitive episodes of breathing pauses during sleep may provide a potential basis for much of the unexplained risk factors underlying AF.

In prior research, she and her colleagues established a strong association between sleep apnea and AF, basing their findings on thousands of participants in large scale epidemiologic cohorts. The data, however, did not include information characterizing changes in heart structure, nor did it include temporally collected, detailed biochemical measures collected from blood and urine, which can indicate how inflammation and oxidative stress caused by sleep apnea may lead to AF.

The newly funded research aims to gather more specific data, obtained by examining images of the heart that detail its pumping function and the condition of its walls.

Sleep apnea results in intermittent lowering of oxygen levels, alteration of nervous system function and changes the pressures within the chest, resulting in immediate, direct changes in the heart. Some or all of these factors may increase AF propensity, Dr. Mehra explains. Sleep apnea may also result in longer-term changes in cardiac structure which can also increase AF risk, prior research has shown.

The basis of the new research will be a case control study of 150 individuals with paroxysmal AF (PAF), an occasional, irregular heart rhythm and early-stage risk factor for persistent AF, which occurs before changes in the heart's condition and function are present and also involves 150 individuals serving as matched controls. A subset of those with PAF who are identified to have sleep apnea will also undergo treatment for their sleep apnea.

In addition, the researchers seek to clarify the extent by which the frequency of stopped breathing, the type of sleep apnea and reduced oxygen supply are associated with PAF, independent of any structural abnormalities in the heart. Throughout their study, researchers will assess how changes in cardiac structure, inflammation, or autonomic nervous system dysfunction are involved in the relationship between sleep apnea and PAF, identifying if patterns of AF differ in patients with sleep apnea.

The research findings could identify key outcomes for clinical trials and ultimately bolster evidence for considering sleep apnea as a potential target for new strategies to reduce AF-related morbidity including stroke, heart failure and also death.
'/>"/>

Contact: Jessica Studeny
jessica.studeny@case.edu
216-368-4692
Case Western Reserve University
Source:Eurekalert

Related medicine news :

1. Wayne State receives $1.9 million from NIH to create novel cystic fibrosis treatments
2. 19 Million New STD Infections Reported Annually, CDC Says
3. University of Alaska science station nets $16 million award
4. Rice chemists cram 2 million nanorods into single cancer cell
5. Flu Hits 90 Million Children Under 5 Each Year
6. Getting on your nerves: $1.4 million NIH grant to study the regeneration of nerves
7. Scripps Research scientist receives $1 million research grant from Novo Nordisk
8. Scott & White Cancer Research Institute receives $3.5 million grant
9. Earthquakes Put Millions of Lives, Major Cities at Risk
10. Penn collaborates on $8 million Barretts esophagus research network
11. NYUCD awarded $2.2 million NIH grant to decode genome of caries-causing bacteria
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2016)... Bensonhurst, NY (PRWEB) , ... May 23, 2016 , ... ... Enrico Ferdico took the time to summarize the weight loss process: , New patients ... a Body Composition Analysis (BCA) to get accurately evaluated. , Body Composition Analysis, There ...
(Date:5/23/2016)... , ... May 23, 2016 , ... According to an article published May ... massive role in oral health and hygiene. The article points out that, as long as ... their toothbrushes will become worn and frayed. Of course, these worn-out bristles won’t clean teeth ...
(Date:5/23/2016)... , ... May 23, 2016 , ... According to an ... in an exuberant mood since the birth of her son, Rockwell Lloyd Liu, and ... ever had.” The “Elementary” and “Kill Bill” star explains that, as a career oriented ...
(Date:5/23/2016)... ... May 23, 2016 , ... The Clinical Data ... from the Japan PMDA, US FDA, industry and academia at the 2016 ... format data from clinical trials so that it can be shared and compared, ...
(Date:5/23/2016)... ... ... NYDNRehab, a New York City-based physical therapy clinic , is introducing ... type of technology, which was developed by world-renowned researcher Dr. Christopher Powers of University ... With over 10 million sport injuries per year in the United States, ...
Breaking Medicine News(10 mins):
(Date:5/22/2016)... 23, 2016 DS Biopharma ... and anti-inflammatory compound DS102 in chronic obstructive pulmonary ... steatohepatitis (NASH) patients. Recent DS preclinical ... lung tissue and has bronchodilatory, anti-inflammatory and anti-fibrotic ... The Company will publish further detail on these ...
(Date:5/20/2016)... ReportsnReports.com adds "Plaque Psoriasis ... research report with comprehensive information on the therapeutic ... comparative analysis at various stages, therapeutics assessment by ... administration (RoA) and molecule type, along with latest ... also reviews key players involved in the therapeutic ...
(Date:5/19/2016)... Oregon , May 19, 2016 ... titled, World Medical/Diagnostic Imaging Market -Opportunities and Forecasts, 2015 ... reach $45.0 billion by 2022, registering a CAGR of ... expected to continue to be the highest revenue-generating segment ... accounted for around one-third of the market share ...
Breaking Medicine Technology: