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$3.5 million NIH grant supports AIDS vaccine research at UC Santa Cruz
Date:9/9/2009

manufacturing and intellectual property rights for the vaccine are now held by Global Solutions for Infectious Diseases (GSID). Results of the trial, which concluded earlier this year, are expected to be announced in October at the AIDS Vaccine 2009 international conference in Paris (http://www.hivvaccineenterprise.org/conference/2009/index.aspx). The clinical trial tested a "prime-boost" vaccine regimen, in which a vaccine developed by Aventis Pasteur was used as a "priming" vaccine, followed by the GSID vaccine as a "booster." The community-based clinical trial involved 16,000 volunteers in southeast Thailand.

Berman said the research funded by the new grant will complement the data from the RV 144 trial. Using the "swarm analysis" technique and the bioinformatics and genomics expertise of his UCSC colleagues, Berman's group will be studying the evolution of the virus and the host's immune response during the early stages of HIV infection. Blood serum samples collected during earlier VaxGen clinical trials involving intravenous drug users are a crucial resource for these studies.

"It's a lemons to lemonade kind of thing, building on information from a failed vaccine trial to move the field forward in a different way," Berman said.


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Contact: Tim Stephens
stephens@ucsc.edu
831-459-2495
University of California - Santa Cruz
Source:Eurekalert

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