Navigation Links
$2.5 million Defense Department grant funds gene therapy study for Lou Gehrig's disease
Date:4/1/2014

LOS ANGELES (April 1, 2014) The Cedars-Sinai Regenerative Medicine Institute has received a $2.5 million grant from the Department of Defense to conduct animal studies that, if successful, could provide the basis for a clinical trial of a gene therapy product for patients with Lou Gehrig's disease, also called amyotrophic lateral sclerosis, or ALS.

The incurable disorder attacks muscle-controlling nerve cells motor neurons in the brain, brainstem and spinal cord. As the neurons die, the ability to initiate and control muscle movement is lost. Patients experience muscle weakness that steadily leads to paralysis; the disease usually is fatal within five years of diagnosis. Several genes have been identified in familial forms of ALS, but most cases are caused by a complex combination of unknown genetic and environmental factors, experts believe.

Because ALS affects a higher-than-expected percentage of military veterans, especially those returning from overseas duties, the Defense Department invests $7.5 million annually to search for causes and treatments. The Cedars-Sinai study, led by Clive Svendsen, PhD, professor and director of the Regenerative Medicine Institute at Cedars-Sinai Medical Center, and Genevive Gowing, PhD, a senior scientist in his laboratory, also will involve a research team at the University of Wisconsin, Madison and a Netherlands-based biotechnology company, uniQure, that has extensive experience in human gene therapy research and development.

The research will be conducted in laboratory rats bred to model a genetic form of ALS. If successful, it could have implications for patients with other types of the disease and could translate into a gene therapy clinical trial for this devastating disease.

It centers on a protein, GDNF, that promotes the survival of neurons. In theory, transporting GDNF into the spinal cord could protect neurons and slow disease progression, but attempts so far have failed, l
'/>"/>

Contact: Sandy Van
sandy@prpacific.com
808-526-1708
Cedars-Sinai Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Marriage linked to lower heart risks in study of 3.5+ million adults
2. Scripps Florida scientist awarded $2.3 million to study dengue fever and related viruses
3. The Brain & Behavior Research Foundation awards $4 million in NARSAD Grants
4. Einstein helps establish $28 million consortium to find ebola treatment
5. Stroke in children will be focus of $3 million grant
6. UTMB receives $3.2 million to continue collaborative research on cancer in Texas
7. NCI recommends the Wistar Institute receive $14.9 million support grant renewal
8. Cancer treatment, artery repair are goals of $3 million in NIH grants
9. UC Irvine stem cell researchers awarded $1.54 million in state funding
10. UCSF receives $50 million gift
11. UCSF team wins $2.7 million grant for innovative project to reduce premature births
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... 2014 Top 10 Best SEO ... hosting companies and highly recommended FatCow ( http://www.top10bestseohosting.com/go/FatCow.com/ ... manager of Top 10 Best SEO Hosting states, ... server hosting supplier. Actually, these companies have outperformed ... and customer support. People can get the best ...
(Date:8/22/2014)... With the stage set for the ... Expo - which will be held in Boston August ... in its online opinion section, Podium. The op-ed ... co-authored by Steven C. Anderson, IOM, CAE, president & ... the MCPHS University School of Pharmacy – Worcester/Manchester. ...
(Date:8/22/2014)... By Amy Norton ... (HealthDay News) -- A growing number of Americans on ... a new study. Researchers found that between 2007 ... Security Disability Insurance benefits were prescribed narcotic painkillers each ... from 21 percent in 2007 to 23 percent in ...
(Date:8/22/2014)... August 22, 2014 Millennium Treatment ... in Lantana, FL, recently launched a new website. ... for information can now find Millennium Treatment Group ... just went live at the beginning of July. ... facility can be found on the website. There’s ...
(Date:8/22/2014)... oncogenic somatic mutation at amino acid 918 in the ... small cell lung cancer (SCLC) tumors and enforced expression ... intracellular signaling and cell growth. , SCLC is a ... all lung cancers and is strongly associated with tobacco ... extensively examined for genomic alterations and targeted therapies are ...
Breaking Medicine News(10 mins):Health News:FatCow Reviews Released by Top10BestSEOHosting.com 2Health News:The Boston Globe Publishes Value of Pharmacy Op-ed as NACDS Total Store Expo Begins 2Health News:The Boston Globe Publishes Value of Pharmacy Op-ed as NACDS Total Store Expo Begins 3Health News:Many U.S. Workers on Disability Use Narcotic Painkillers, Study Finds 2Health News:Many U.S. Workers on Disability Use Narcotic Painkillers, Study Finds 3Health News:Many U.S. Workers on Disability Use Narcotic Painkillers, Study Finds 4Health News:Millennium Treatment Group Has a New Website 2Health News:Novel oncogenic RET mutation found in small cell lung cancer 2
... and lack of proper sleep could be threatening thousands ... warns Heart and Stroke Foundation researcher Dr. Brian McCrindle, ... in Toronto. "Sleep disorders in kids are on ... other increasing cardiovascular risk factors such as overweight and ...
... 25, 2010 Young children who consume substantial amounts ... with fluoridated water or by swallowing fluoride toothpaste have ... to research published in the October issue of The ... supported by the National Institute of Dental and Craniofacial ...
... fear some of it unjustified are common among ... as MRSA, according to the results of a small study ... timely, detailed and simple information, the researchers add. ... Pediatrics , underscore the need for healthcare staff to do ...
... Reporter , MONDAY, Oct. 25 (HealthDay News) -- Why is ... the next day one person ends up feeling more tired ... in their genes, a new study suggests. Researchers at ... individuals who test positive for a common gene variant are ...
... Randy Dotinga HealthDay Reporter , MONDAY, Oct. 25 ... -- to be honest about their drug use, a new ... extent of drug use, but this new research finds that ... for drugs or they,re told the results will be confidential. ...
... treated with a combination of hormone therapy and radiation have ... do not receive radiation, according to interim results of the ... session, November 1, 2010, at the 52nd Annual Meeting of ... 1995 to 2005, 1,205 men with high-risk prostate cancer in ...
Cached Medicine News:Health News:Cardiac wakeup call for Canadian kids 2Health News:Cardiac wakeup call for Canadian kids 3Health News:Substantial consumption of fluoride increases chance of mild fluorosis 2Health News:Knowledge gaps, fears common among parents of children with drug-resistant bacteria 2Health News:Knowledge gaps, fears common among parents of children with drug-resistant bacteria 3Health News:How You Handle Lack of Sleep May Be in Your Genes 2Health News:How You Handle Lack of Sleep May Be in Your Genes 3Health News:Teens, Parents Often Lie About Illicit Drug Use 2Health News:Adding radiation to hormone therapy for prostate cancer treatment will increase survival chances 2
(Date:8/22/2014)... 22, 2014 Research ... addition of the  "Global Operating Room Equipment ...      (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ,An operating ... environment in a healthcare facility used to ... technically advanced equipment, which ensures patient care ...
(Date:8/22/2014)... -- Research and Markets  has announced the addition ... & Technologies" report to their offering. ... or you wish to expand your product line, you,ll ... The authors know you want to make effective product ... generate improved revenues and take market share from your ...
(Date:8/22/2014)... Research and Markets has announced ... Respirators Industry Report 2014" report to their offering. ... Industry Report 2014 is a professional and in-depth study ... industry with a focus on the Chinese situation. ... including definitions, classifications, applications and industry chain structure. The ...
Breaking Medicine Technology:Global Operating Room Equipment Market 2014-2018: Key Vendors are Getinge, STERIS, Stykron and TRUMPF Medical Systems 2Global Stem Cell Research Products: Opportunities, Tools & Technologies - 2014 Report 2Global Stem Cell Research Products: Opportunities, Tools & Technologies - 2014 Report 3Global and Chinese Particulate Respirators Industry Report 2014 2
... to a report recently issued by the Centers for ... toll from prescription painkiller overdose, Reckitt Benckiser Pharmaceuticals Inc. ... more about the disease of addiction, available options and ... . The new CDC report showed ...
... Calif., Nov. 10, 2011 Telik, Inc. (Nasdaq: ... the 53rd Annual Meeting of the American Society of ... are as follows: Phase 1 ... Combination with Lenalidomide (Revlimid®) in Patients with Non-Deletion(5q) Low ...
Cached Medicine Technology:New Report Puts Spotlight on Epidemic of Painkiller Abuse and Need for Patient Education and Resources 2Telik Announces Telintra Clinical Presentations at the Annual Meeting of the American Society of Hematology 2
Castroviejo "HM" Micro Needle Holder with Tungsten-Carbide Inserts, with catch. Serrated....
Barraquer needle holder, curved, delicate....
Clinical micro clamps by Acland. Black finish. It provides impressive security in use, both against slippage and against leakage due to controlled closing force and working grip surface....
Clinical micro clamps by Acland. Black finish. It provides impressive security in use, both against slippage and against leakage due to controlled closing force and working grip surface....
Medicine Products: