Navigation Links
$2.5 million Defense Department grant funds gene therapy study for Lou Gehrig's disease
Date:4/1/2014

LOS ANGELES (April 1, 2014) The Cedars-Sinai Regenerative Medicine Institute has received a $2.5 million grant from the Department of Defense to conduct animal studies that, if successful, could provide the basis for a clinical trial of a gene therapy product for patients with Lou Gehrig's disease, also called amyotrophic lateral sclerosis, or ALS.

The incurable disorder attacks muscle-controlling nerve cells motor neurons in the brain, brainstem and spinal cord. As the neurons die, the ability to initiate and control muscle movement is lost. Patients experience muscle weakness that steadily leads to paralysis; the disease usually is fatal within five years of diagnosis. Several genes have been identified in familial forms of ALS, but most cases are caused by a complex combination of unknown genetic and environmental factors, experts believe.

Because ALS affects a higher-than-expected percentage of military veterans, especially those returning from overseas duties, the Defense Department invests $7.5 million annually to search for causes and treatments. The Cedars-Sinai study, led by Clive Svendsen, PhD, professor and director of the Regenerative Medicine Institute at Cedars-Sinai Medical Center, and Genevive Gowing, PhD, a senior scientist in his laboratory, also will involve a research team at the University of Wisconsin, Madison and a Netherlands-based biotechnology company, uniQure, that has extensive experience in human gene therapy research and development.

The research will be conducted in laboratory rats bred to model a genetic form of ALS. If successful, it could have implications for patients with other types of the disease and could translate into a gene therapy clinical trial for this devastating disease.

It centers on a protein, GDNF, that promotes the survival of neurons. In theory, transporting GDNF into the spinal cord could protect neurons and slow disease progression, but attempts so far have failed, l
'/>"/>

Contact: Sandy Van
sandy@prpacific.com
808-526-1708
Cedars-Sinai Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Marriage linked to lower heart risks in study of 3.5+ million adults
2. Scripps Florida scientist awarded $2.3 million to study dengue fever and related viruses
3. The Brain & Behavior Research Foundation awards $4 million in NARSAD Grants
4. Einstein helps establish $28 million consortium to find ebola treatment
5. Stroke in children will be focus of $3 million grant
6. UTMB receives $3.2 million to continue collaborative research on cancer in Texas
7. NCI recommends the Wistar Institute receive $14.9 million support grant renewal
8. Cancer treatment, artery repair are goals of $3 million in NIH grants
9. UC Irvine stem cell researchers awarded $1.54 million in state funding
10. UCSF receives $50 million gift
11. UCSF team wins $2.7 million grant for innovative project to reduce premature births
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/3/2015)... BC (PRWEB) June 03, 2015 Vancouver ... announced that the firm will now handle personal injury ... Greater Vancouver on the rise, more and more people ... year bus accidents cause needless suffering, serious injury and ... a result of a bus accident in BC you ...
(Date:6/3/2015)... June 03, 2015 Array Health ... technology, has announced that CEO Jonathan Rickert will present ... on June 4, 2015. The session will address ... are disrupting traditional business models in health care, and ... , WHAT: Digital Transformation and the Health Care ...
(Date:6/3/2015)... 2015 A group of nine authors ... a Global Inspire Award at DIA’s upcoming Annual Meeting. ... volunteers for their leadership, level of excellence, and commitment ... The recipients of the Author(s) of the Year Award, ... article has made a significant impact in advancing medical ...
(Date:6/3/2015)... 2015 Z-Medica®, LLC, a leading developer ... has been designated as National Safety Month by the ... Police Department for its commitment to public safety. ... Individual First Aid Kits (IFAK) over 100 times in ... stabbings or traffic accidents. Each kit is equipped with ...
(Date:6/3/2015)... NC (PRWEB) June 03, 2015 Researchers ... two biomarkers for mesothelioma and say the tried-and-true marker ... just posted an article on the research. Click ... the University’s National Center for Asbestos Related Diseases say, ... positive results, it is still preferable to fibulin-3 for ...
Breaking Medicine News(10 mins):Health News:Jiwa Law Corporation Now Handles Personal Injury Claims Involving Bus Accidents 2Health News:Array Health’s CEO to Present at America’s Health Insurance Plans Institute 2015 2Health News:Authors Representing TransCelerate BioPharma Inc. to Be Honored with Global Inspire Award at DIA’s 2015 51st Annual Meeting 2Health News:Authors Representing TransCelerate BioPharma Inc. to Be Honored with Global Inspire Award at DIA’s 2015 51st Annual Meeting 3Health News:Authors Representing TransCelerate BioPharma Inc. to Be Honored with Global Inspire Award at DIA’s 2015 51st Annual Meeting 4Health News:Z-Medica Commends Tucson Police Department for Trauma Kit Utilization 2Health News:Analysis Reveals Gold Standard Mesothelioma Biomarker Still the Best, According to Surviving Mesothelioma 2
... Secretary of State Colin Powell, a strong advocate for national ... the world and call upon them to continue their efforts ... , (Logo: http://www.newscom.com/cgi-bin/prnh/20081014/DC38855LOGO ) ... the importance and value of volunteerism as part of the ...
... FDA compliant solution that works within minutes to relieve the ... on stings caused by the Portuguese man-of-war. Jellyfish Squish(TM) ... can be purchased online and at select stores including drug ... of 2009 Dr. Peter Verity, a world renowned marine biologist ...
... August and September, PF Week Sept. 14 - 21 ... for Pulmonary Fibrosis (CPF) announced today it has scheduled its 2009 ... The primary goals of this year,s activity are to ensure passage ... of Congress and in communities nationwide. , , Specifically, the ...
... ... ... National HIV Testing Day, June 27, by encouraging people of all ages to learn about HIV, ... vaginal fluids or breast milk. Exposure to any of these fluids can put you at ...
... and Medicare plan participants in Ga. now have access ... , June 25 UnitedHealthcare and ... services of Fusion Sleep,s sleep disorder program available to ... , , "Fusion Sleep provides a very important ...
... French . , Montreal, June 25th 2009 ... have two choices: inject them with medication to dissolve the ... open the blocked artery (primary percutaneous coronary intervention (PCI)). Guidelines ... that do not take "real-life" conditions into account. The latest ...
Cached Medicine News:Health News:Colin Powell Applauds Lions for Leadership in Volunteerism as Interest in Volunteer Service Grows 2Health News:Popular Jellyfish Sting Treatment Also Proven Effective on Stings From Portuguese Man-of-War 2Health News:Popular Jellyfish Sting Treatment Also Proven Effective on Stings From Portuguese Man-of-War 3Health News:CPF Announces Dates for Seventh Annual National Pulmonary Fibrosis Awareness Week 2Health News:CPF Announces Dates for Seventh Annual National Pulmonary Fibrosis Awareness Week 3Health News:CPF Announces Dates for Seventh Annual National Pulmonary Fibrosis Awareness Week 4Health News:Planned Parenthood Recognizes National HIV Testing Day 2Health News:UnitedHealthcare and Fusion Sleep Announce New Agreement 2Health News:Research: Improving treatment of patients with heart attack 2
(Date:6/3/2015)... , June 3, 2015  Diomics today announced that ... senior official, has joined the company,s board of directors, ... Intelligence Studies Project and Clinical Professor at the Lyndon ... of Texas at Austin. "Steve brings ... served 28 years as a member of CIA,s clandestine ...
(Date:6/3/2015)... CORONA, Calif. , June 3, 2015  Giving ... is the ultimate mission of the International Academy ... offer treatments and resources that are at the forefront ... eye care professionals in the technology and latest treatment ... that has not been remedied with traditional means. Recently, ...
(Date:6/3/2015)... -- Research and Markets ( http://www.researchandmarkets.com/research/t3kkhg/the_future_of ) has ... of Pharmaceutical Outsourcing" report to their offering. ... need to develop better drugs with high success ... increasingly utilizing external resources to increase their efficiency ... internal operation. Their outsourcing demands and proportions have ...
Breaking Medicine Technology:Former CIA Clandestine Service Senior Official Stephen B. Slick joins Diomics Board of Directors 2International Academy of Low Vision Specialists Announces Training of Doctors in Six New States and Canada 2International Academy of Low Vision Specialists Announces Training of Doctors in Six New States and Canada 3International Academy of Low Vision Specialists Announces Training of Doctors in Six New States and Canada 4The Future of Pharmaceutical Outsourcing: 2015 Report 2
... (NYSE: AME ) today announced that it ... of custom, fine-featured components used in the medical device ... in Montevideo, MN, has annual sales of approximately $25 ... of businesses that serve the highly attractive medical device ...
... NEW YORK, April 28, 2011 Reportlinker.com ... is available in its catalogue: ... Healthcare System and Drug Regulatory Overview: Cost-containment ... http://www.reportlinker.com/p0487111/Pharmaceutical-Key-Trends-2011---Healthcare-System-and-Drug-Regulatory-Overview-Cost-containment-and-regulatory-pressures-intensify.html ...
Cached Medicine Technology:AMETEK ACQUIRES AVICENNA TECHNOLOGY 2Reportlinker Adds Pharmaceutical Key Trends 2011 - Healthcare System and Drug Regulatory Overview: Cost-containment and regulatory pressures intensify 2Reportlinker Adds Pharmaceutical Key Trends 2011 - Healthcare System and Drug Regulatory Overview: Cost-containment and regulatory pressures intensify 3Reportlinker Adds Pharmaceutical Key Trends 2011 - Healthcare System and Drug Regulatory Overview: Cost-containment and regulatory pressures intensify 4Reportlinker Adds Pharmaceutical Key Trends 2011 - Healthcare System and Drug Regulatory Overview: Cost-containment and regulatory pressures intensify 5Reportlinker Adds Pharmaceutical Key Trends 2011 - Healthcare System and Drug Regulatory Overview: Cost-containment and regulatory pressures intensify 6
...
... A wide range of miniTHERM incubators is ... appropriate application solution for their specific requirements. ... liters, are compact and extremely space saving. ... microwave oven. It is possible to stack ...
... miniTHERM incubators is available, ensuring the customers ... their specific requirements. miniTHERM incubators have a ... extremely space saving. Their size corresponds approximately ... possible to stack up to three units ...
... miniTHERM incubators is available, ensuring the customers ... their specific requirements. miniTHERM incubators have a ... extremely space saving. Their size corresponds approximately ... possible to stack up to three units ...
Medicine Products: