Navigation Links
$2.4 million grant for study of corneal infections associated with contact lenses
Date:3/20/2008

Contact lens wearers are often warned to properly clean their lenses to prevent infections that can lead to severe inflammation, intense pain, and sight impairment.

Researchers from University Hospitals Case Medical Center and Case Western Reserve University School of Medicine have been awarded a $2.4 million grant over five years from the National Eye Institute (NEI) to study corneal infection (keratitis) brought on by disease-causing fungi that can be lurking on contact lenses, in the air, in the dirt, or even on common household surfaces.

They will set their sights on Fusarium solani, the ubiquitous fungus that achieved international notoriety in 2005 and 2006 after an outbreak of corneal infections related to a contact lens care solution in the United States.

The researchers will study the bodys immune response to Fusarium and other pathogenic fungi, and will identify factors that fuel the infections.

Leading the study are Eric Pearlman, Ph.D., research director and research professor in the Department of Ophthalmology and Visual Sciences, and Mahmoud Ghannoum, Ph.D., director of the Center for Medical Mycology in the Department of Dermatology. This award recognizes the complementary expertise of the two researchers. Dr. Pearlman is an expert in microbial infections and immune defense, while Dr. Ghannoum is expert in fungal pathogenesis.

Fusarium solani was already well-known as an important cause of eye infections in warm, humid areas of the U.S., and in southern and southeastern Asia, where this fungus can be picked up from the digging of dirt in agricultural work, Dr. Pearlman said. A couple of years ago, we saw it cause a lot of trouble in contact lens wearers because cleaning solutions werent able to scrub it away. Once it got into peoples eyes, it caused many problems and led to a recall of a cleaning solution.

Earlier this year, this research team published a study that described how fungal cells formed biofilms, highly resistant structures held together with a glue-like matrix material.

Once they live in that type of state, the cells become resistant to lens solutions and immune to the bodys own defense system, said Dr. Ghannoum.

UH Case Medical Center and Case Western Reserve University School of Medicine, mainly through the Department of Ophthalmology and the Visual Sciences Research Center, receive more than $41 million in vision research grants from the NEI, one of the National Institutes of Health. The NEI conducts and supports research to help prevent and treat eye diseases and other disorders of vision.


'/>"/>

Contact: George Stamatis
george.stamatis@UHhospitals.org
216-844-3667
University Hospitals of Cleveland
Source:Eurekalert

Related medicine news :

1. Alseres Pharmaceuticals, Inc. Raises $5 Million
2. Good luck indeed: 53 million-year-old rabbits foot bones found
3. Brookdale Board of Directors Authorizes $150 Million Share Repurchase Program
4. Columbia University Medical Center/NYPH receive $28 million donation toward curing diabetes
5. GSK Charitable Support Valued at $564 Million in 2007
6. Exploring the Aaah ... $1 Million Grant Advances Aquatic Health Research
7. Aflac Reaches $40 Million Milestone in Donations to the Aflac Cancer Center and Blood Disorders Service of Childrens Healthcare of Atlanta
8. 10 Million Baby Boomers Face Alzheimers, Report Predicts
9. Attorney General Corbett Announces $36.7 Million Multi-State Settlement With CVS/Caremark in National Dosage-Switching Investigation
10. CVS Caremark Corp. to Pay $36.7 Million to U.S., 23 States, & D.C. to Settle Medicaid Prescription Drug Fraud Allegations
11. CVS, Americas Largest Pharmacy Chain, Pays Nearly $37 Million to Settle Federal and State Generic Drug Switching Charges
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/12/2016)... ... February 12, 2016 , ... Erlanger Agency has announced a new partnership in ... latest campaign focuses on the fight against breast cancer, fundraising for a local woman ... here . , Carmen is a loving single mother of two boys who also ...
(Date:2/12/2016)... ... , ... Miami Dental Specialists is excited to bring patients the choice of ... January, Miami Dental Specialists will offer the non-metal implants as a safe, holistic and ... chosen by the dental implant manufacturer, Straumann, to bring this cutting-edge technology to Miami. ...
(Date:2/12/2016)... York, NY (PRWEB) , ... February 12, 2016 ... ... edition of “Revolutionizing Cancer Care.” , The print component of “Revolutionizing ... Chicago, Dallas, Pittsburgh/Cleveland, New York, Washington DC/Baltimore, and Seattle, with a circulation of ...
(Date:2/12/2016)... ... February 12, 2016 , ... Homeowners ... exterior design possibilities. CertainTeed, North America’s leading brand of building products, has improved ... offerings showcased in the mobile version of the ColorView® Exterior Style and Color ...
(Date:2/12/2016)... ... February 12, 2016 , ... Healthcare careers in the medical laboratory, nursing, ... via the website of healthcare staffing leader Aureus Medical Group during the month of ... travel therapy positions and in travel and direct hire opportunities in other ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... Inc. (NYSE: DPLO ) is pleased to announce the promotion of Paul Urick ... 23, 2016. To learn more about our ... ... ... In his redefined ...
(Date:2/12/2016)... 12, 2016   HeartWare International, Inc . (NASDAQ: ... webcast to discuss its financial results for the three ... February 25, 2016 at 8:00 a.m. ET.  The company ... conference call and webcast.  On the conference call and ... from the fourth quarter and business outlook.   ...
(Date:2/12/2016)... 12, 2016  Sequent Medical, Inc. announced today that ... evaluate the safety and effectiveness of the WEB™ Aneurysm ... intracranial aneurysms.  Prof Laurent Spelle , MD, Head ... Paris, France and Principal Investigator of the ... France and Germany.  Although patients with ruptured ...
Breaking Medicine Technology: