Navigation Links
$2.4 million grant for study of corneal infections associated with contact lenses
Date:3/20/2008

Contact lens wearers are often warned to properly clean their lenses to prevent infections that can lead to severe inflammation, intense pain, and sight impairment.

Researchers from University Hospitals Case Medical Center and Case Western Reserve University School of Medicine have been awarded a $2.4 million grant over five years from the National Eye Institute (NEI) to study corneal infection (keratitis) brought on by disease-causing fungi that can be lurking on contact lenses, in the air, in the dirt, or even on common household surfaces.

They will set their sights on Fusarium solani, the ubiquitous fungus that achieved international notoriety in 2005 and 2006 after an outbreak of corneal infections related to a contact lens care solution in the United States.

The researchers will study the bodys immune response to Fusarium and other pathogenic fungi, and will identify factors that fuel the infections.

Leading the study are Eric Pearlman, Ph.D., research director and research professor in the Department of Ophthalmology and Visual Sciences, and Mahmoud Ghannoum, Ph.D., director of the Center for Medical Mycology in the Department of Dermatology. This award recognizes the complementary expertise of the two researchers. Dr. Pearlman is an expert in microbial infections and immune defense, while Dr. Ghannoum is expert in fungal pathogenesis.

Fusarium solani was already well-known as an important cause of eye infections in warm, humid areas of the U.S., and in southern and southeastern Asia, where this fungus can be picked up from the digging of dirt in agricultural work, Dr. Pearlman said. A couple of years ago, we saw it cause a lot of trouble in contact lens wearers because cleaning solutions werent able to scrub it away. Once it got into peoples eyes, it caused many problems and led to a recall of a cleaning solution.

Earlier this year, this research team published a study that described how fungal cells formed biofilms, highly resistant structures held together with a glue-like matrix material.

Once they live in that type of state, the cells become resistant to lens solutions and immune to the bodys own defense system, said Dr. Ghannoum.

UH Case Medical Center and Case Western Reserve University School of Medicine, mainly through the Department of Ophthalmology and the Visual Sciences Research Center, receive more than $41 million in vision research grants from the NEI, one of the National Institutes of Health. The NEI conducts and supports research to help prevent and treat eye diseases and other disorders of vision.


'/>"/>

Contact: George Stamatis
george.stamatis@UHhospitals.org
216-844-3667
University Hospitals of Cleveland
Source:Eurekalert

Related medicine news :

1. Alseres Pharmaceuticals, Inc. Raises $5 Million
2. Good luck indeed: 53 million-year-old rabbits foot bones found
3. Brookdale Board of Directors Authorizes $150 Million Share Repurchase Program
4. Columbia University Medical Center/NYPH receive $28 million donation toward curing diabetes
5. GSK Charitable Support Valued at $564 Million in 2007
6. Exploring the Aaah ... $1 Million Grant Advances Aquatic Health Research
7. Aflac Reaches $40 Million Milestone in Donations to the Aflac Cancer Center and Blood Disorders Service of Childrens Healthcare of Atlanta
8. 10 Million Baby Boomers Face Alzheimers, Report Predicts
9. Attorney General Corbett Announces $36.7 Million Multi-State Settlement With CVS/Caremark in National Dosage-Switching Investigation
10. CVS Caremark Corp. to Pay $36.7 Million to U.S., 23 States, & D.C. to Settle Medicaid Prescription Drug Fraud Allegations
11. CVS, Americas Largest Pharmacy Chain, Pays Nearly $37 Million to Settle Federal and State Generic Drug Switching Charges
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... CA (PRWEB) , ... June 25, 2016 , ... As ... with Magna Cum Laude and his M.D from the David Geffen School of Medicine ... and returned to Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published June 14 ... The article goes on to state that individuals are now more comfortable seeking to ... operations such as calf and cheek reduction. The Los Angeles area medical group, Beverly ...
(Date:6/24/2016)... Texas (PRWEB) , ... June 24, 2016 , ... ... International Conference and Scientific Sessions in Dallas that it will receive two significant ... of the grants came as PHA marked its 25th anniversary by recognizing patients, ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway ... call for a minimum wage raise to $12 an hour by 2020 and then adjusting ... restore the lost value of the minimum wage, assure the wage floor does not erode ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... Grove Investment Group (TGIG), has initiated cultivation and processing operations at its production ... and Pahrump, Nevada. , Puradigm is the manufacturer of a complete system of ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Research and Markets has announced the addition of ... report to their offering. ... The World Market for Companion Diagnostics covers the world market ... the report includes the following: , World ... Region (N. America, EU, ROW), 2015-2020 , World IVD ...
(Date:6/24/2016)... Tenn. , June 24, 2016  Arkis ... providing less invasive and more durable cerebrospinal fluid ... in funding.  The Series-A funding is led by ... Lighthouse Fund, and other private investors.  Arkis, new ... neurosurgical instrumentation and the market release of its ...
(Date:6/23/2016)... Research and Markets has announced ... Type (Organic Chemical (Sugar, Petrochemical, Glycerin), Inorganic Chemical), Functionality ... - Global Forecast to 2021" report to their ... global pharmaceutical excipients market is projected to reach USD ... in the forecast period 2016 to 2021. ...
Breaking Medicine Technology: