Navigation Links
$2.2M NIH grant to develop drugs to suppress cocaine cravings
Date:11/16/2007

The University of Illinois at Chicago College of Pharmacy has received a $2.2 million federal grant to develop therapeutics to suppress the cravings of cocaine addicts.

Compounds developed by a research team led by Alan Kozikowski, professor of medicinal chemistry and pharmacognosy, will target one particular family of serotonin receptors in the brain. Recent evidence, he said, strongly suggests that these receptors, called 5-HT2 receptors, are important in controlling a person's desire to use drugs.

Researchers looking for therapies for cocaine addiction have largely overlooked the 5-HT2 receptor as a target, Kozikowski said, and focused on dopamine receptors instead.

"In large part, the field of cocaine medications research has been dominated by the so-called 'dopamine hypothesis,' where cocaine is known to block the re-uptake of the neurotransmitter dopamine.

"The higher levels of dopamine present in the cleft between neighboring neurons leads to cocaine's high," Kozikowski said. "This has led to years of work on the discovery of compounds that might displace cocaine from its binding site on the dopamine transporter, while still allowing dopamine to be taken up through the transporter.

"Success with this particular approach has been marginal at best."

The new target is a broad group of receptors that bind serotonin, also called 5-HT for its chemical name, 5-hydroxytryptamine. It is a neurotransmitter that controls a wide variety of behaviors, including anger, cognition, sleep, attention, sexuality and appetite. Low levels of serotonin may be associated with many health disorders, including clinical depression, obsessive-compulsive disorder, migraine headaches, irritable bowel syndrome and bipolar disorder.

The mode of action of 5-HT is complex, and at least seven different receptor 'families' are known, each located in various parts of the body and triggering different responses. Kozikowski's team is investigating the 5-HT2 family, of which there are three subtypes.

"The 5-HT2a and 5-HT2c receptors may play a role in the strong conditioned associations made between cocaine and environmental cues," Kozikowski said. Drugs highly specific for just those receptors will need to be developed, he said, because interactions with other members of the family can cause hallucinations and heart valve problems.

Kozikowski's collaborators -- a research team led by Dr. Bryan Roth of the University of North Carolina, Chapel Hill -- have identified an antidepressant drug as a possible lead candidate to identify other 5-HT2c-receptor-binding compounds that may be useful. This compound emerged after nearly 800 compounds in a chemical library were screened.

New 5-HT2c-receptor-binding compounds might be useful "both as research tools and as potential therapeutics for use in treating cocaine addiction and possibly other disorders, including obesity," Kozikowski said.

"We have already generated about 100 new [receptor-binding compounds] showing much higher potency and subtype selectivity than shown by the original 'hit' compound," Kozikowski said. "Further structure-activity studies are underway to fine-tune the compounds to a point where high activity is maintained at the 5-HT2c sub-type with little or no activity at the other subtypes."

Kozikowski said tests are currently being conducted in animal models at the University of Texas Medical Branch in Galveston by his collaborators Kenneth Johnson Jr. and Kathryn Cunningham.


'/>"/>

Contact: Sam Hostettler
samhos@uic.edu
312-355-2522
University of Illinois at Chicago
Source:Eurekalert

Related medicine news :

1. UVa researcher awarded $3.6 million grant to fight drug-resistant bacteria
2. UT Southwesterns obesity research receives $22 million NIH Roadmap grant
3. $21.8 Million NIH Grant for Fragile X Research
4. Bioniche Receives $2 Million Government Grant For Market Development Related to its E. coli O157:H7 Cattle Vaccine
5. Boston University School of Medicine researcher recipient of Memory Ride Grant
6. RAND researchers offer options to improve immigrant health care quality, access
7. Pennsylvania Department of Aging Receives Grant to Improve Alzheimers Support
8. CAS Medical Systems, Inc. Awarded $2.8 Million Grant by National Institutes of Health
9. NIH awards Einstein multimillion dollar grant to extend studies of exceptional longevity
10. Johns Hopkins receives $100 million grant to speed research from clinic to community
11. Major grant advances UWs clinical and translational research enterprise
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/21/2017)... Raton, FL (PRWEB) , ... January 21, 2017 , ... ... Germany, announced it is bringing its product to the United States as part of ... over the last 25 years, Alcovit aims to reduce the productions of nasty toxins ...
(Date:1/21/2017)... ... January 21, 2017 , ... ... Relations, Dianne Travis-Teague, the electrifying line-up of events for its annual meeting “Coming ... friends, and community. “Coming Home 2017” will be held on Friday January ...
(Date:1/21/2017)... Austin, Texas (PRWEB) , ... January 21, 2017 ... ... surgeries performed by Austin, Texas Periodontist Dr. Dan Holtzclaw in media for its ... features two surgeries performed by Dr. Holtzclaw in which he utilizes creos™ ...
(Date:1/20/2017)... ... 20, 2017 , ... Source Vitál Apothecary, a skin and body care company ... the company had a successful visit to the 2017 ECRM Diet, Vitamin & Sports ... work in the nutritional, sports and health industries a chance to meet in private ...
(Date:1/20/2017)... ... January 20, 2017 , ... ... to enhance people’s everyday lives, recently attended the January ECRM Trade Show in ... Science is known for its large range of supplements that keep the body ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... Calif. , Jan. 19, 2017 Accuray ... its CyberKnife® and TomoTherapy® Systems continue to set the ... received the highest composite overall user satisfaction rating among ... the Q4 2016 MD Buyline Market Intelligence Briefing™. The ... the highest composite ratings among industry peers for 11 ...
(Date:1/19/2017)... BOCA RATON, Fla. , Jan. 19, 2017 ... ), a medical device company specializing in the ... conditions, such as keloids, with superficial radiation therapy, ... quarter and full year 2016 financial results on Thursday, ... The Company will hold a conference call ...
(Date:1/19/2017)... 19, 2017   Science Exchange , the leading ... that the first five replication studies from the ... published in eLife today. Despite intense scrutiny around ... practical evaluation of reproducibility rates that may identify ... other assessments of reproducibility, the results of this ...
Breaking Medicine Technology: