Navigation Links
$2.2M NIH grant to develop drugs to suppress cocaine cravings
Date:11/16/2007

The University of Illinois at Chicago College of Pharmacy has received a $2.2 million federal grant to develop therapeutics to suppress the cravings of cocaine addicts.

Compounds developed by a research team led by Alan Kozikowski, professor of medicinal chemistry and pharmacognosy, will target one particular family of serotonin receptors in the brain. Recent evidence, he said, strongly suggests that these receptors, called 5-HT2 receptors, are important in controlling a person's desire to use drugs.

Researchers looking for therapies for cocaine addiction have largely overlooked the 5-HT2 receptor as a target, Kozikowski said, and focused on dopamine receptors instead.

"In large part, the field of cocaine medications research has been dominated by the so-called 'dopamine hypothesis,' where cocaine is known to block the re-uptake of the neurotransmitter dopamine.

"The higher levels of dopamine present in the cleft between neighboring neurons leads to cocaine's high," Kozikowski said. "This has led to years of work on the discovery of compounds that might displace cocaine from its binding site on the dopamine transporter, while still allowing dopamine to be taken up through the transporter.

"Success with this particular approach has been marginal at best."

The new target is a broad group of receptors that bind serotonin, also called 5-HT for its chemical name, 5-hydroxytryptamine. It is a neurotransmitter that controls a wide variety of behaviors, including anger, cognition, sleep, attention, sexuality and appetite. Low levels of serotonin may be associated with many health disorders, including clinical depression, obsessive-compulsive disorder, migraine headaches, irritable bowel syndrome and bipolar disorder.

The mode of action of 5-HT is complex, and at least seven different receptor 'families' are known, each located in various parts of the body and triggering different responses. Kozikowski's te
'/>"/>

Contact: Sam Hostettler
samhos@uic.edu
312-355-2522
University of Illinois at Chicago
Source:Eurekalert

Page: 1 2

Related medicine news :

1. UVa researcher awarded $3.6 million grant to fight drug-resistant bacteria
2. UT Southwesterns obesity research receives $22 million NIH Roadmap grant
3. $21.8 Million NIH Grant for Fragile X Research
4. Bioniche Receives $2 Million Government Grant For Market Development Related to its E. coli O157:H7 Cattle Vaccine
5. Boston University School of Medicine researcher recipient of Memory Ride Grant
6. RAND researchers offer options to improve immigrant health care quality, access
7. Pennsylvania Department of Aging Receives Grant to Improve Alzheimers Support
8. CAS Medical Systems, Inc. Awarded $2.8 Million Grant by National Institutes of Health
9. NIH awards Einstein multimillion dollar grant to extend studies of exceptional longevity
10. Johns Hopkins receives $100 million grant to speed research from clinic to community
11. Major grant advances UWs clinical and translational research enterprise
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2015)... DC (PRWEB) , ... September 03, 2015 , ... ... of nominations to determine who among America’s policymakers, public servants, activists, corporate executives, ... the nation’s health care. This year, that process led the magazine to tap ...
(Date:9/2/2015)... ... 02, 2015 , ... Chris Harrison of Harrison’s Footwear of Poulsbo announces the ... really,” says Chris. “We have a lot of repeat customers, and many of them ... for them—so we’ve given them the convenience of ordering from home.” , Harrison’s Footwear ...
(Date:9/2/2015)... ... 02, 2015 , ... Healthegy, a leading producer of conferences, ... will deliver keynote presentations at the upcoming Digital Healthcare Innovation Summit ( http://www.digitalhealthcaresummit.com/ ... , Larry Renfro, CEO of Optum, will deliver the morning address. In his ...
(Date:9/2/2015)... Los Angeles, CA (PRWEB) , ... September 02, 2015 , ... ... working to expand their fleet of truly superb luxury vehicles based on which of ... are pleased to announce the latest step forward in pursuit of this goal: a ...
(Date:9/2/2015)... ... September 02, 2015 , ... ... the Abraham and Mildred Goldstein Charitable Trust to establish the Abraham and Mildred ... comes six months after WCHN recruited nationally known gynecologic oncologist Thomas J. Rutherford, ...
Breaking Medicine News(10 mins):Health News:NLN CEO Dr. Beverly Malone Named One of 100 Most Influential in Health Care 2Health News:NLN CEO Dr. Beverly Malone Named One of 100 Most Influential in Health Care 3Health News:Harrison's Comfort Footwear Announces Expansion with New CHarrison Online Store 2Health News:Larry Renfro, CEO of Optum and Jonathan Bush, CEO of AthenaHealth to Address Healthcare Entrepreneurs and Investors at 5th Annual Digital Healthcare Innovation Summit 2Health News:Larry Renfro, CEO of Optum and Jonathan Bush, CEO of AthenaHealth to Address Healthcare Entrepreneurs and Investors at 5th Annual Digital Healthcare Innovation Summit 3Health News:Luxury Line Auto Rental Announces Addition of the Rolls Royce Wraith to their Luxury Fleet 2Health News:Western Connecticut Health Network Receives $1 Million Gift to Establish Ovarian Cancer Research Endowment 2Health News:Western Connecticut Health Network Receives $1 Million Gift to Establish Ovarian Cancer Research Endowment 3
... is helping to increase understanding about normal vaginal biology ... women prone to infections and other diseases, and ... suffer from insidious health problems, including bacterial vaginosis and ... to seek medical treatment, said Larry Forney, a professor ...
... times as much food as conventional farming on the ... refute the long-standing assumption that organic farming methods cannot ... ,Researchers from the University of Michigan found that ... and conventional farms. In developing countries, food production could ...
... found that children with Tourettes syndromean inherited neurological disorder ... learn certain mental grammar skills much faster than their ... at Georgetown University Medical Center and the Kennedy Krieger ... linked to tics in Tourettes syndrome may also result ...
... of Havana have found that two compounds from lobster ... properties. ,The researchers said that the compounds could ... and antiseptic properties, as well as to increase growth ... a very common polymer present in nature as part ...
... Laboratories announced primary results for its large-scale clinical ... non-hormonal, non-prescription Zestra(R) Feminine Arousal Fluid for ... study, designed and managed by David M. Ferguson, ... parallel design trial intended to expand on the ...
... day, the Australian police finally announced that the Dr.Mohammed ... charged with providing reckless support to terrorists by ... ,His cousin Sabeel Ahmed 26, who worked at Halton ... of having information that could have helped police prevent ...
Cached Medicine News:Health News:Vaginal Bacteria Vary Among Healthy Women 2Health News:Organic Farming Can Feed the World 2Health News:Organic Farming Can Feed the World 3Health News:Tourettes Syndrome in Children may also Result in Superior Learning Skills 2Health News:Lobster Shells Have Great Healing and Antiseptic Properties 2Health News:Study Shows Positive Results for Zestra(R) Feminine Arousal Fluid 2Health News:Three Doctors Charged So Far in the UK Bombing Case 2Health News:Three Doctors Charged So Far in the UK Bombing Case 3Health News:Three Doctors Charged So Far in the UK Bombing Case 4
(Date:9/2/2015)... LONDON , Sept. 2, 2015 ... Forecasts Summary Advanced dressings have steadily ... treatment of a variety of wound indications, such ... fluid management, infection control, and physical protection become ... a greater role in standard therapy. This ...
(Date:9/2/2015)... , Sept. 2, 2015 STAAR Surgical Company (NASDAQ: ... implantable lenses and delivery systems for the eye, today announced ... Wall to the Company,s Board. Mr. ... Boston -based investment firm, for more than ... Board of Directors, and chair of the Corporate Governance Committee ...
(Date:9/2/2015)... -- Research and Markets ( http://www.researchandmarkets.com/research/hcb7bz/pharmaceutical ) has announced ... UK - November 16-18, 2015)" conference to their offering. ... including Columbia, Peru , Brazil ... Uruguay , Paraguay , Venezuela ... , Chile This seminar can be ...
Breaking Medicine Technology:Advanced Wound Dressings - 5EU Analysis and Market Forecasts 2William P. Wall Appointed to STAAR Surgical Board of Directors 2Pharmaceutical Regulatory Affairs in Latin America Seminar - London, UK - November 16-18, 2015 2
... NetMotion Wireless, a leading provider of mobile productivity ... mobile Virtual Private Network (VPN) solution, Mobility XE, has ... hundreds of mobile workers for accessing wireless data and ... advance medical care, improve staff productivity and increase practice ...
... Sept. 7 MAP Pharmaceuticals, Inc. (Nasdaq: MAPP ) ... conferences in September: Morgan Stanley Global Healthcare Conference ... York Stifel Nicolaus 2010 Healthcare ConferenceWednesday, September 15, at ... Conference Tuesday, September 21, at 9:00 a.m. ET in ...
Cached Medicine Technology:NetMotion Wireless Tapped by IDEXX Laboratories to Provide Secure Mobile Access to Field Personnel 2NetMotion Wireless Tapped by IDEXX Laboratories to Provide Secure Mobile Access to Field Personnel 3MAP Pharmaceuticals to Present at Upcoming Healthcare and Scientific Conferences 2
... flexible lighting products. The first is available ... sizes 5", 10", and 15" (refers to ... These lights are for use in procedures ... second group of flexible lights is our ...
These units, though small, still offer sufficient output to ensure current is fully adjustable from 0 to 70 mA. Instruction manual, ball electrodes, battery and leads with alligator clips are include...
These units, though small, still offer sufficient output to ensure current is fully adjustable from 0 to 70 mA. Instruction manual, ball electrodes, battery and leads with alligator clips are include...
... standby switch maintains power to the instrument without generating ... of 50 Hz separated by .75 s; repeats every ... Hz (2 pulses/s) , Tetanus: 50 Hz (50 ... pulses/2 s; repeats every 10 s , Output Current: ...
Medicine Products: