Navigation Links
$16.8 million study will breathe new life into cancer battle

University of Manchester scientists are among a multinational collaborative group to have been awarded 12 million for cancer research by the European Union.

The research will focus on tumour hypoxia, which describes an oxygen-deprived state that is common to all solid tumours.

Hypoxia causes a huge problem in cancer therapy because hypoxic cells are resistant to radiotherapy and most forms of chemotherapy; as a result, patients with hypoxic tumours respond less well to treatment.

Furthermore, hypoxia also appears to increase the chance that a tumour will spread and form metastases in other parts of the body. If a tumour begins to spread to other areas it becomes much more difficult to treat and so most cancer-related deaths are associated with metastases.

Recent advances in biological research have meant that there is now a greater understanding of the process of metastasis and why hypoxia plays such a key role. The researchers in this study aim to build on these advances and translate biological findings into clinically relevant treatments that will ultimately lead to improved patient response.

The Manchester team, led by Dr Kaye Williams in the School of Pharmacy and Pharmaceutical Sciences, will investigate how hypoxia changes cell behaviour and makes them more likely to metastasise. The scientists will then examine how these events can be targeted using specific therapies.

Further collaborative studies will attempt to develop novel ways of identifying patients with hypoxic tumours, which will mean their anti-cancer treatment can be tailored towards their specific tumour type.

"Working alongside our internationally leading colleagues within the rest of the research consortium, there is a huge opportunity to develop new therapies and imaging strategies that will benefit many cancer patients with solid malignancies," said Dr Williams.

"Hypoxia causes huge problems in the effective treatment of many cancers, so understanding how it alters the behaviour of cells will be a major breakthrough and should help us to develop therapeutic interventions that will make tumours less deadly."


Contact: Aeron Haworth
University of Manchester

Related medicine news :

1. Cardinal Health Foundation Awards $1 Million to Fund Patient Safety Initiatives
2. Arena Pharmaceuticals to Receive $100 Million from Deerfield Management
3. Cell Therapeutics Announces Preliminary Results of its Fixed Price Exchange Offers for Any and All of its $118.9 Million Convertible Notes Outstanding
4. GlaxoSmithKline Opens $600million Vaccine Plant In Singapore
5. GE Launches Program to Doctors, Hospitals to Accelerate EMR Adoption; First $100 Million of healthymagination Commitment
6. PDI, Inc. Announces New Business Wins Exceeding $18 Million
7. Saint Thomas Health Services Partners With Curaspan on Patient Flow Initiative Resulting in Estimated Savings of Nearly $6 Million
8. Quest Diagnostics Announces Pricing of Tender Offer for Up to $200 Million Aggregate Principal Amount of Certain of its Outstanding Notes
9. Former Gov. Bill Clements Makes Historic Gift to UT Southwestern With $100 Million Transformative Contribution
10. With 15 Million Kids Expected to Go Hungry This Summer, Boys & Girls Clubs of America Partners With Morgan Stanley to Launch Million Meal Summer Program
11. State to Invest $11.1 Million in Expansion of Doylestown Hospital
Post Your Comments:
(Date:11/25/2015)... , ... November 25, 2015 , ... Dental professionals who ... Cleveland, OH , are invited to attend Dr. Mark Iacobelli’s Advanced Implant Mentoring (AIM) ... in Cleveland, OH. , As the co-founders of Advanced Implant Mentoring (AIM), Dr. ...
(Date:11/25/2015)... IL (PRWEB) , ... November 25, 2015 , ... The ... announce a recent successful appellate decision obtained by Attorneys Francisco J. Botto and Alex ... Adcock v. Illinois Workers’ Compensation Comm’n, 2015 IL App (2d) 130884WC. , According to ...
(Date:11/25/2015)... (PRWEB) , ... November 25, 2015 , ... ... a double board certified facial plastic surgeon specializing in both surgical and non-surgical ... of The Skin Spa at Hobgood Facial Plastic Surgery. , Highly trained ...
(Date:11/25/2015)... ... November 25, 2015 , ... In an ongoing Clinical Study ... (RMC) in Chicago, IL, UV Angel is evaluating the efficacy of its product and ... care units (totaling 30 beds) from May 2014 through October 2015 at a 360-bed, ...
(Date:11/25/2015)... Missouri (PRWEB) , ... November 25, 2015 , ... ... HEAL, will provide scholarships for people struggling with eating disorders as a result ... from the second annual event, held at Fox Run Golf Club in Eureka, ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... SAN FRANCISCO , November 26, 2015 ... 1.82 billion by 2022, according to a new report by ... as Chronic Kidney Disease (CKD) which demands kidney transplantation is ... convenient and cost effective substitute for organ transplantation. --> ... 1.82 billion by 2022, according to a new report by ...
(Date:11/26/2015)... 26, 2015 ... of the  "2016 Future Horizons and ... Surface Testing Market: Supplier Shares, Competitive ... offering.  --> ) ... "2016 Future Horizons and Growth Strategies ...
(Date:11/26/2015)... , Nov. 26, 2015 Research and Markets ... "Advanced Wound Care Market by Type (Dressings, Therapy ... User (In-Patient Facility, Out-Patient Facility), and Geography - Global ... --> --> The ... definition and forecast of the global advanced wound care ...
Breaking Medicine Technology: