Navigation Links
$16.8 million study will breathe new life into cancer battle
Date:6/18/2009

University of Manchester scientists are among a multinational collaborative group to have been awarded 12 million for cancer research by the European Union.

The research will focus on tumour hypoxia, which describes an oxygen-deprived state that is common to all solid tumours.

Hypoxia causes a huge problem in cancer therapy because hypoxic cells are resistant to radiotherapy and most forms of chemotherapy; as a result, patients with hypoxic tumours respond less well to treatment.

Furthermore, hypoxia also appears to increase the chance that a tumour will spread and form metastases in other parts of the body. If a tumour begins to spread to other areas it becomes much more difficult to treat and so most cancer-related deaths are associated with metastases.

Recent advances in biological research have meant that there is now a greater understanding of the process of metastasis and why hypoxia plays such a key role. The researchers in this study aim to build on these advances and translate biological findings into clinically relevant treatments that will ultimately lead to improved patient response.

The Manchester team, led by Dr Kaye Williams in the School of Pharmacy and Pharmaceutical Sciences, will investigate how hypoxia changes cell behaviour and makes them more likely to metastasise. The scientists will then examine how these events can be targeted using specific therapies.

Further collaborative studies will attempt to develop novel ways of identifying patients with hypoxic tumours, which will mean their anti-cancer treatment can be tailored towards their specific tumour type.

"Working alongside our internationally leading colleagues within the rest of the research consortium, there is a huge opportunity to develop new therapies and imaging strategies that will benefit many cancer patients with solid malignancies," said Dr Williams.

"Hypoxia causes huge problems in the effective treatment of many cancers, so understanding how it alters the behaviour of cells will be a major breakthrough and should help us to develop therapeutic interventions that will make tumours less deadly."


'/>"/>

Contact: Aeron Haworth
aeron.haworth@manchester.ac.uk
44-161-275-8383
University of Manchester
Source:Eurekalert

Related medicine news :

1. Cardinal Health Foundation Awards $1 Million to Fund Patient Safety Initiatives
2. Arena Pharmaceuticals to Receive $100 Million from Deerfield Management
3. Cell Therapeutics Announces Preliminary Results of its Fixed Price Exchange Offers for Any and All of its $118.9 Million Convertible Notes Outstanding
4. GlaxoSmithKline Opens $600million Vaccine Plant In Singapore
5. GE Launches Program to Doctors, Hospitals to Accelerate EMR Adoption; First $100 Million of healthymagination Commitment
6. PDI, Inc. Announces New Business Wins Exceeding $18 Million
7. Saint Thomas Health Services Partners With Curaspan on Patient Flow Initiative Resulting in Estimated Savings of Nearly $6 Million
8. Quest Diagnostics Announces Pricing of Tender Offer for Up to $200 Million Aggregate Principal Amount of Certain of its Outstanding Notes
9. Former Gov. Bill Clements Makes Historic Gift to UT Southwestern With $100 Million Transformative Contribution
10. With 15 Million Kids Expected to Go Hungry This Summer, Boys & Girls Clubs of America Partners With Morgan Stanley to Launch Million Meal Summer Program
11. State to Invest $11.1 Million in Expansion of Doylestown Hospital
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/10/2016)... IN (PRWEB) , ... February 10, 2016 , ... ... benefits advisory organization, welcomes S.S. Nesbitt as the latest addition to its growing ... has seven other locations throughout the Southeast, from Orlando to Huntsville and in ...
(Date:2/10/2016)... ... February 10, 2016 , ... Pediatric therapists are challenged ... Research shows that the Goal Attainment Scale (GAS) captures 20% more change in ... learn more about the Goal Attainment Scale, Education Resources Inc. is offering a ...
(Date:2/10/2016)... ... February 10, 2016 , ... ... and accessories. These PEEK-lined stainless steel (PLS) columns combine the strength of traditional ... ensures the integrity of biological samples while operating at ultra-high pressures of 20,000 ...
(Date:2/10/2016)... ... February 10, 2016 , ... Anxiety of older Americans over steep cost ... Part D a decade ago, according to The Senior Citizens League (TSCL). ... they are coping with rapidly rising costs. “The implications are chilling, particularly for ...
(Date:2/10/2016)... ... February 09, 2016 , ... Traumatic Brian Injury is ... may be one of many possible sources: sports, car accidents, falls, work accidents, ... Mastering Rehab Solutions for the Complexities of Concussions is designed for ...
Breaking Medicine News(10 mins):
(Date:2/9/2016)...  Sangamo BioSciences, Inc. (NASDAQ: SGMO ), ... its fourth quarter and full year 2015 financial ... therapeutic genome editing," said Edward Lanphier, Sangamo,s president ... (ZFN) technology leads the therapeutic genome editing field ... to move our ground-breaking genome editing programs through ...
(Date:2/9/2016)... Mast Therapeutics, Inc. (NYSE MKT: MSTX), ... disease and heart failure, today announced that it intends to ... stock in an underwritten public offering.  The offering is subject ... assurance as to whether or when the offering may be ... the offering.   --> --> ...
(Date:2/9/2016)... The global prefilled syringes market accounted for $3,905.1 million ... with a CAGR of 12.9% during 2015-2020. Among the ... global prefilled syringes market, with 90.1% share in 2014. ... global market of prefilled syringes is up surging with ... demand for vaccines, increasing prevalence of chronic and lifestyle ...
Breaking Medicine Technology: