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$12 million NIH grant to study acute lung injury
Date:7/29/2011

nd will address the very important question of modulating the S1P receptors to thwart ALI."

Dr. Steve Dudek, associate professor in pulmonary, critical care and sleep medicine at UIC, will lead a third project, working with researchers at the City University of New York to develop analogues of S1P and another molecule to increase their therapeutic potential.

"Our goal ultimately is drug development, working through the Institute for Personalized Respiratory Medicine to actually test some of these analogues in the clinical setting," said Natarajan.

The final project, led by Dr. Jeffrey Jacobson, associate professor in pulmonary, critical care and sleep medicine, and Dr. Ralph Weichselbaum, chief of services in radiation oncology at UIC and chairman of radiation and cellular oncology at the University of Chicago, will investigate ALI using the radiation-induced lung injury animal model.

"Radiation also can cause ALI in people," said Natarajan. "This study is likely to facilitate the development of tailor-made S1P analogues alone or in combination with statins to combat different forms of ALI."

Natarajan said the team "wants to quickly move from bench to bedside, finding ways to minimize the lung injury, and propel the patients on a path of rapid recovery."


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Contact: Jeanne Galatzer-Levy
jgala@uic.edu
312-996-1583
University of Illinois at Chicago
Source:Eurekalert

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