Navigation Links
$12 million NIH grant to study acute lung injury
Date:7/29/2011

Researchers at the University of Illinois at Chicago College of Medicine have been awarded more than $11.7 million to study the pathology of severe lung injury.

The study, part of a multi-pronged investigation into acute lung injury, or ALI, is funded by the National Heart, Lung and Blood Institute, one of the National Institutes of Health.

ALI and its even more severe form, acute respiratory distress syndrome, result from pulmonary edema -- leaky blood vessels -- and inflammation. Direct lung injury from infection or indirect injury from trauma, sepsis, pancreatitis, transfusions, radiation or drug overdose can trigger ALI. It is fatal almost 40 percent of the time.

"We are now ready to address the very important, clinically relevant aspects of the pathobiology of ALI and investigate novel therapeutic approaches," said Natarajan, program director and professor of pharmacology and medicine at UIC, who has been studying ALI for 20 years. Natarajan also co-directs the Institute for Personalized Respiratory Medicine at UIC with Dr. Joe G.N. "Skip" Garcia, University of Illinois vice president for health affairs, UIC vice chancellor for research and Earl M. Bane Professor of Medicine.

The NIH Program Project Grant is an interdisciplinary investigation of a bio-active lipid called sphingosine-1-phosophate, or S1P, and its receptors and their role in lung cell signaling, inflammation and injury caused by sepsis or radiation.

One project, led by Natarajan, will use animal and cell-culture models to investigate how S1P is generated inside cells and how it exerts a protective effect in ALI -- an effect which Garcia, Natarajan and their collaborators had demonstrated previously in animal models of ALI.

A second project, headed by Garcia, will investigate the role of S1P receptors in ALI.

"Dr. Garcia brings cutting-edge expertise in genomics, genetics and clinical medicine to the project," Natarajan said, "and will address the very important question of modulating the S1P receptors to thwart ALI."

Dr. Steve Dudek, associate professor in pulmonary, critical care and sleep medicine at UIC, will lead a third project, working with researchers at the City University of New York to develop analogues of S1P and another molecule to increase their therapeutic potential.

"Our goal ultimately is drug development, working through the Institute for Personalized Respiratory Medicine to actually test some of these analogues in the clinical setting," said Natarajan.

The final project, led by Dr. Jeffrey Jacobson, associate professor in pulmonary, critical care and sleep medicine, and Dr. Ralph Weichselbaum, chief of services in radiation oncology at UIC and chairman of radiation and cellular oncology at the University of Chicago, will investigate ALI using the radiation-induced lung injury animal model.

"Radiation also can cause ALI in people," said Natarajan. "This study is likely to facilitate the development of tailor-made S1P analogues alone or in combination with statins to combat different forms of ALI."

Natarajan said the team "wants to quickly move from bench to bedside, finding ways to minimize the lung injury, and propel the patients on a path of rapid recovery."


'/>"/>

Contact: Jeanne Galatzer-Levy
jgala@uic.edu
312-996-1583
University of Illinois at Chicago
Source:Eurekalert

Related medicine news :

1. WU studies obesity, cancer link with $9.2 million grant
2. NIH awards WSU researcher $1.7 million to study non-alcoholic fatty liver disease
3. Harvard School of Public Health receives $14.1 million to test childbirth checklist
4. INFORMS study: OR models of hepatitis B prove decisive in treating millions in US, China
5. Penn receives $10 million to create center for orphan disease research and therapy
6. Study: Doctors differ in how best to care for Americas 12 million cancer survivors
7. BUSM/BMC researchers awarded $3.5 million grant from the NIDA
8. Lifestyle Changes Might Prevent Millions of Cases of Alzheimers
9. Columbia University Medical Center receives $38.9 million to help translate science into treatment
10. New therapy provides hope for millions of people suffering from bowel incontinence
11. UCSF receives $112 million to help translate science into cures
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/10/2016)... ... February 10, 2016 , ... United Benefit ... as the latest addition to its growing list of Partner Firms. S.S. ... Southeast, from Orlando to Huntsville and in between. , Harnessing the experience and ...
(Date:2/10/2016)... ... February 10, 2016 , ... AHRA: ... winner and inspirational speaker Jan Fox will serve as keynote speaker at the ... provide participants with tools to more effectively communicate with their own organizational staff ...
(Date:2/10/2016)... ... February 10, 2016 , ... ... it has been awarded the prestigious Distinguished Emerald Club of the World award, ... by BoardRoom magazine, one of the most respected trade publications serving private clubs. ...
(Date:2/10/2016)... Petaluma, CA (PRWEB) , ... February 10, 2016 , ... ... newest and most versatile series of monitor mounts ever. , “Our goal was ... flexible and easy to install system that we have ever created.” said Darren Hulsey, ...
(Date:2/10/2016)... ... February 09, 2016 , ... A new leadership team for Mid-South ... President Joe Wiley made the announcement Monday night, Feb. 8, prior to the evening ... of FHU and the creator of GO! Camp, has been named director. Gayle McDonald, ...
Breaking Medicine News(10 mins):
(Date:2/9/2016)... , February 9, 2016 ... announced a collaboration with 10x Genomics to develop ... single-cell biology and bioinformatics. --> QGEN ... collaboration with 10x Genomics to develop and promote ... and bioinformatics. --> QIAGEN N.V. (NASDAQ: ...
(Date:2/9/2016)... 9, 2016 Mast Therapeutics, Inc. (NYSE ... sickle cell disease and heart failure, today announced that it ... purchase common stock in an underwritten public offering.  The offering ... be no assurance as to whether or when the offering ... terms of the offering.   --> ...
(Date:2/9/2016)... FRANCISCO , February 9, 2016 ... biotechnology company focused on developing products for Regenerative Medicine, ... be a featured presenting company at Source Capital Group,s ... on February 10-11, 2016 in New York ... on Wednesday, February 10, 2016 at 12:30 pm by ...
Breaking Medicine Technology: