Navigation Links
$12 million NIH grant to study acute lung injury
Date:7/29/2011

Researchers at the University of Illinois at Chicago College of Medicine have been awarded more than $11.7 million to study the pathology of severe lung injury.

The study, part of a multi-pronged investigation into acute lung injury, or ALI, is funded by the National Heart, Lung and Blood Institute, one of the National Institutes of Health.

ALI and its even more severe form, acute respiratory distress syndrome, result from pulmonary edema -- leaky blood vessels -- and inflammation. Direct lung injury from infection or indirect injury from trauma, sepsis, pancreatitis, transfusions, radiation or drug overdose can trigger ALI. It is fatal almost 40 percent of the time.

"We are now ready to address the very important, clinically relevant aspects of the pathobiology of ALI and investigate novel therapeutic approaches," said Natarajan, program director and professor of pharmacology and medicine at UIC, who has been studying ALI for 20 years. Natarajan also co-directs the Institute for Personalized Respiratory Medicine at UIC with Dr. Joe G.N. "Skip" Garcia, University of Illinois vice president for health affairs, UIC vice chancellor for research and Earl M. Bane Professor of Medicine.

The NIH Program Project Grant is an interdisciplinary investigation of a bio-active lipid called sphingosine-1-phosophate, or S1P, and its receptors and their role in lung cell signaling, inflammation and injury caused by sepsis or radiation.

One project, led by Natarajan, will use animal and cell-culture models to investigate how S1P is generated inside cells and how it exerts a protective effect in ALI -- an effect which Garcia, Natarajan and their collaborators had demonstrated previously in animal models of ALI.

A second project, headed by Garcia, will investigate the role of S1P receptors in ALI.

"Dr. Garcia brings cutting-edge expertise in genomics, genetics and clinical medicine to the project," Natarajan said, "and will address the very important question of modulating the S1P receptors to thwart ALI."

Dr. Steve Dudek, associate professor in pulmonary, critical care and sleep medicine at UIC, will lead a third project, working with researchers at the City University of New York to develop analogues of S1P and another molecule to increase their therapeutic potential.

"Our goal ultimately is drug development, working through the Institute for Personalized Respiratory Medicine to actually test some of these analogues in the clinical setting," said Natarajan.

The final project, led by Dr. Jeffrey Jacobson, associate professor in pulmonary, critical care and sleep medicine, and Dr. Ralph Weichselbaum, chief of services in radiation oncology at UIC and chairman of radiation and cellular oncology at the University of Chicago, will investigate ALI using the radiation-induced lung injury animal model.

"Radiation also can cause ALI in people," said Natarajan. "This study is likely to facilitate the development of tailor-made S1P analogues alone or in combination with statins to combat different forms of ALI."

Natarajan said the team "wants to quickly move from bench to bedside, finding ways to minimize the lung injury, and propel the patients on a path of rapid recovery."


'/>"/>

Contact: Jeanne Galatzer-Levy
jgala@uic.edu
312-996-1583
University of Illinois at Chicago
Source:Eurekalert

Related medicine news :

1. WU studies obesity, cancer link with $9.2 million grant
2. NIH awards WSU researcher $1.7 million to study non-alcoholic fatty liver disease
3. Harvard School of Public Health receives $14.1 million to test childbirth checklist
4. INFORMS study: OR models of hepatitis B prove decisive in treating millions in US, China
5. Penn receives $10 million to create center for orphan disease research and therapy
6. Study: Doctors differ in how best to care for Americas 12 million cancer survivors
7. BUSM/BMC researchers awarded $3.5 million grant from the NIDA
8. Lifestyle Changes Might Prevent Millions of Cases of Alzheimers
9. Columbia University Medical Center receives $38.9 million to help translate science into treatment
10. New therapy provides hope for millions of people suffering from bowel incontinence
11. UCSF receives $112 million to help translate science into cures
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... (PRWEB) , ... June 27, 2016 , ... ... for mental health professionals, announced today its affiliation with Tennessee Counseling Association. ... solutions to the network of the Tennessee Counseling Association, adding exclusive benefits and ...
(Date:6/26/2016)... PLAINSBORO, N.J. (PRWEB) , ... June 27, 2016 , ... ... same sources, yet in many ways they remain in the eye of the beholder, ... Oncology (EBO), a publication of The American Journal of Managed Care. For the full ...
(Date:6/26/2016)... ... June 26, 2016 , ... Brent Kasmer, a legally blind and certified personal trainer is ... a fitness app. The fitness app plans to fix the two major problems leading the ... one size fits all type program , They don’t eliminate all the reasons ...
(Date:6/25/2016)... ... 25, 2016 , ... The temporary closing of Bruton Memorial Library on June 21 due to ... a new, often overlooked aspect of head lice: the parasite’s ability to live away from ... common occurrence, but a necessary one in the event that lice have simply gotten out ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. ... from injury. Recently, he has implemented orthobiologic procedures as a method for treating ... one of the first doctors to perform the treatment. Orthobiologics are substances that ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 Research ... World Market for Companion Diagnostic Tests" report to their ... Market for Companion Diagnostics The World Market ... and personalized medicine diagnostics. Market analysis in the report includes ... Test Market (In Vitro Diagnostic Kits) by Region (N. America, ...
(Date:6/24/2016)... 24, 2016  Arkis BioSciences, a leading innovator ... more durable cerebrospinal fluid treatments, today announced it ... funding is led by Innova Memphis, followed by ... private investors.  Arkis, new financing will accelerate the ... market release of its in-licensed Endexo® technology. ...
(Date:6/23/2016)... 2016 Research and Markets has ... by Type (Organic Chemical (Sugar, Petrochemical, Glycerin), Inorganic Chemical), ... Parenteral) - Global Forecast to 2021" report to ... The global pharmaceutical excipients market is projected to reach ... 6.1% in the forecast period 2016 to 2021. ...
Breaking Medicine Technology: