Navigation Links
$1 million from W.M. Keck Foundation spurs development of new generation 3-D 'Cell-CT' imaging
Date:3/2/2011

The W. M. Keck Foundation has awarded Arizona State University (ASU) a $1 million grant to the team of scientists led by Deirdre Meldrum, Ph.D., at the Biodesign Institute. The team is working to build a next-generation, three-dimensional (3D) imaging microscope, called a "Cell-CT" scanner, that will perform functional computed tomographic (CT) imaging of individual living cells. This groundbreaking technology will allow researchers to observe and assess the cellular function and disease status of living cells, enabling scientists to gain new insights into the metabolic pathways of disease, such as cancer.

This next-generation Cell-CT scanner offers a transformative view of the biological structural and functional inter-relationships at the single cell level. Leveraging leading-edge technology developed by VisionGate, Inc. (Phoenix, AZ, http://www.visiongate3d.com/) in collaboration with Meldrum's team, this project will advance applications in basic and clinical science, deepening scientific understanding of metabolism and disease processes, and expanding the horizons of medical diagnostics.

The Biodesign Institute at ASU is boldly pushing the frontiers of science and medicine to uncover transformative solutions to the most urgent and complex challenges in human health, national security, and the well-being of our planet. Driven by passion and collaborative synergy, scientific inquiry and technology research and development, and fusing biosciences, engineering, and advanced computing to fuel the translation of research advances into real solutionsBiodesign and Meldrum's Center for Biosignature Discovery Automation (CBDA) are finding the clues that will enable us to diagnose and treat cancer sooner, in more targeted ways.

In Computed Tomography (CT), multiple 2D images taken from many perspectives are analyzed computationally to create a 3D rendering of a living structure or tissue. In diagnostic radiology, x-ray CT takes hundreds of perspective views around a single axis to create a cross sectional view through the patient's anatomy. Similarly, the Cell-CT combines hundreds of submicron-resolution optical images taken while rotating a single cell to render a functional 3D image of the cell. That image reveals important metabolic and disease processes in action.

One of the biggest challenges in the Cell-CT scanner's development is finding the best way to rotate cells precisely without harming them. Initially, two methods will be explored: the first rotates cells in a microfluidic vortex, and the second rotates cells with an infrared light beam. The technology will be validated through comparison studies between Cell-CT scanned cells grown in culture that represent various stages of cancers, and cells taken from human biopsies spanning the same disease spectrum.

The four-year effort is led by Professor Meldrum, who is head of CBDA at the Biodesign Institute and a leader in microdevices for biological research. Also at CBDA are Roger Johnson, Ph.D., an expert in instrumentation and algorithms for 3D tomographic reconstruction, who will oversee project operations and lead algorithmic and image processing research. Laimonas Kelbauskas, Ph.D., a specialist in laser physics and complex optical system design,will lead the optical physics and engineering team to design and build the new-generation Cell-CT system for living cells. Joining Meldrum from Turku University in Finland is Lea Sistonen, Ph.D., a renowned expert in the effects of cell stress on signaling and gene expression. The strength of this project team is its combination of expertise and experience.

"We're tremendously excited by the potential this technology presents for important breakthroughs, not only in cellular biology but also in medicine and ultimately personalized health care," Meldrum said. The Cell-CT scanner may enable, for the first time, rapid 3D spatial localization of proteins, and assessment of their concentrations in subcellular compartments and microdomains, providing powerful insights concerning relationships between cell structure and function in disease.


'/>"/>

Contact: Joe Caspermeyer
joseph.caspermeyer@asu.edu
480-727-0369
Arizona State University
Source:Eurekalert  

Related medicine news :

1. $1 million USDA grant aims to reduce obesity in preschoolers
2. $7.9 million grant to improve food security, nutrition in Mozambique
3. McKesson Foundation awards $1.3 million in 6 Mobilizing for Health Research grants
4. $1.9 million NIH grant supports research in the most common soft tissue tumor in children
5. 3.1 Million Hispanic Americans Struggle With Arthritis
6. 4.7 million Californians to gain coverage under health reform, new study estimates
7. Fossil Suggests Humans Walked Upright 3 Million Years Ago
8. Johns Hopkins School of Medicine grants $5 million to study cognitive disorders
9. Apica Cardiovascular receives $5.1 million investment for improved heart surgery system
10. Researchers predict nearly 1.3 million cancer deaths in Europe in 2011
11. MDA awards $13.5 million in grants for research treatments for neuromuscular diseases
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
$1 million from W.M. Keck Foundation spurs development of new generation 3-D 'Cell-CT' imaging
(Date:3/24/2017)... (PRWEB) , ... March 24, 2017 , ... ... Center, Sedona, Arizona’s Premier Center for Shamanic Healing and Spiritual Awakening, proudly ... Delgado, June 9--24, 2017. This sacred and spiritual journey during the Summer ...
(Date:3/24/2017)... ... March 24, 2017 , ... ... the Advanced ERISA Benefit Claims Litigation seminar in Chicago, Illinois. She will ... The majority of cases litigated under ERISA involve claims for long-term disability benefits. ...
(Date:3/24/2017)... ... March 24, 2017 , ... Empower Brokerage, located ... training and leads programs. , In February, 2017, Empower Brokerage introduced their new ... Partners is designed to teach how to maximize their sales efforts, as well ...
(Date:3/24/2017)... ... March 24, 2017 , ... “Vintage and Harvest A ... minister and college Bible teacher residing in North Carolina with his wife, Anna Marie. ... blessed them with six grandchildren. David is also the author of “Shadow and Substance.” ...
(Date:3/23/2017)... ... , ... A recent report from the National Council on Teacher Quality (NCTQ) ... suggests, based on a review of GPA and SAT/ACT requirements at 221 institutions in ... It argues that this higher bar should be set by states, by the Council ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... , March 24, 2017 Today Stock-Callers.com ... stocks, which are: Neovasc Inc. (NASDAQ: NVCN), Hologic Inc. (NASDAQ: ... (NASDAQ: SSH ). These companies are part of ... gains on Thursday, March 23 rd , 2017, with the ... shares of health care companies in the S&P 500 were ...
(Date:3/24/2017)... 23, 2017  HealthMine surveys with 9,250 insured consumers ... health plan members want help from their plans in ... in their health, 2) help closing gaps in care, ... health and 5) relevant, real-time guidance. Meeting these needs ... costs. A Reason to Stay ...
(Date:3/24/2017)... -- The Board of Directors of Nordic Nanovector ... including the complete 2016 Annual Accounts with notes. The report ... website in the section Investor Relations/Reports and presentations/Annual Reports. ... For further ... Financial Officer Cell: +47-91-51-95-76 Email: ir@nordicnanovector.com ...
Breaking Medicine Technology: