Navigation Links
$1 million from W.M. Keck Foundation spurs development of new generation 3-D 'Cell-CT' imaging
Date:3/2/2011

The W. M. Keck Foundation has awarded Arizona State University (ASU) a $1 million grant to the team of scientists led by Deirdre Meldrum, Ph.D., at the Biodesign Institute. The team is working to build a next-generation, three-dimensional (3D) imaging microscope, called a "Cell-CT" scanner, that will perform functional computed tomographic (CT) imaging of individual living cells. This groundbreaking technology will allow researchers to observe and assess the cellular function and disease status of living cells, enabling scientists to gain new insights into the metabolic pathways of disease, such as cancer.

This next-generation Cell-CT scanner offers a transformative view of the biological structural and functional inter-relationships at the single cell level. Leveraging leading-edge technology developed by VisionGate, Inc. (Phoenix, AZ, http://www.visiongate3d.com/) in collaboration with Meldrum's team, this project will advance applications in basic and clinical science, deepening scientific understanding of metabolism and disease processes, and expanding the horizons of medical diagnostics.

The Biodesign Institute at ASU is boldly pushing the frontiers of science and medicine to uncover transformative solutions to the most urgent and complex challenges in human health, national security, and the well-being of our planet. Driven by passion and collaborative synergy, scientific inquiry and technology research and development, and fusing biosciences, engineering, and advanced computing to fuel the translation of research advances into real solutionsBiodesign and Meldrum's Center for Biosignature Discovery Automation (CBDA) are finding the clues that will enable us to diagnose and treat cancer sooner, in more targeted ways.

In Computed Tomography (CT), multiple 2D images taken from many perspectives are analyzed computationally to create a 3D rendering of a living structure or tissue. In diagnostic radiology, x-ray CT takes hundreds of perspective views around a single axis to create a cross sectional view through the patient's anatomy. Similarly, the Cell-CT combines hundreds of submicron-resolution optical images taken while rotating a single cell to render a functional 3D image of the cell. That image reveals important metabolic and disease processes in action.

One of the biggest challenges in the Cell-CT scanner's development is finding the best way to rotate cells precisely without harming them. Initially, two methods will be explored: the first rotates cells in a microfluidic vortex, and the second rotates cells with an infrared light beam. The technology will be validated through comparison studies between Cell-CT scanned cells grown in culture that represent various stages of cancers, and cells taken from human biopsies spanning the same disease spectrum.

The four-year effort is led by Professor Meldrum, who is head of CBDA at the Biodesign Institute and a leader in microdevices for biological research. Also at CBDA are Roger Johnson, Ph.D., an expert in instrumentation and algorithms for 3D tomographic reconstruction, who will oversee project operations and lead algorithmic and image processing research. Laimonas Kelbauskas, Ph.D., a specialist in laser physics and complex optical system design,will lead the optical physics and engineering team to design and build the new-generation Cell-CT system for living cells. Joining Meldrum from Turku University in Finland is Lea Sistonen, Ph.D., a renowned expert in the effects of cell stress on signaling and gene expression. The strength of this project team is its combination of expertise and experience.

"We're tremendously excited by the potential this technology presents for important breakthroughs, not only in cellular biology but also in medicine and ultimately personalized health care," Meldrum said. The Cell-CT scanner may enable, for the first time, rapid 3D spatial localization of proteins, and assessment of their concentrations in subcellular compartments and microdomains, providing powerful insights concerning relationships between cell structure and function in disease.


'/>"/>

Contact: Joe Caspermeyer
joseph.caspermeyer@asu.edu
480-727-0369
Arizona State University
Source:Eurekalert  

Related medicine news :

1. $1 million USDA grant aims to reduce obesity in preschoolers
2. $7.9 million grant to improve food security, nutrition in Mozambique
3. McKesson Foundation awards $1.3 million in 6 Mobilizing for Health Research grants
4. $1.9 million NIH grant supports research in the most common soft tissue tumor in children
5. 3.1 Million Hispanic Americans Struggle With Arthritis
6. 4.7 million Californians to gain coverage under health reform, new study estimates
7. Fossil Suggests Humans Walked Upright 3 Million Years Ago
8. Johns Hopkins School of Medicine grants $5 million to study cognitive disorders
9. Apica Cardiovascular receives $5.1 million investment for improved heart surgery system
10. Researchers predict nearly 1.3 million cancer deaths in Europe in 2011
11. MDA awards $13.5 million in grants for research treatments for neuromuscular diseases
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
$1 million from W.M. Keck Foundation spurs development of new generation 3-D 'Cell-CT' imaging
(Date:2/5/2016)... ... February 05, 2016 , ... Stuart Bentkover, MD, FACS ... Designed to provide the most effective tattoo removal today, Dr. Bentkover is the only ... Developed by Cynosure, the PicoSure has been approved by the Food and Drug Administration ...
(Date:2/5/2016)... ... 05, 2016 , ... Colorize is a web theme package created ... next using Colorize's dynamic moving camera. Colorize is perfect for personal and web related ... environment with 1 to 5 focus points per scene, stage floor scene presets that ...
(Date:2/5/2016)... ... ... Health and wellness is a topic that should concern all Americans; however, ... an illness. Migraines are a severe form of a headache and often are accompanied ... the pain on their worst enemy, the feeling can last for many hours and ...
(Date:2/5/2016)... Ramsey, NJ (PRWEB) , ... February 05, 2016 ... ... Optimizing Primary Care for Patients with Rare Diseases, a continuing medical education (CME) ... conference is the first of its kind—and a first for ACCORD, whose mission ...
(Date:2/5/2016)... ... February 05, 2016 , ... KICVentures ( http://www.kicventures.com ) announced ... in New York City on Thursday, January 21, 2016. Kingsley R. Chin, ... alumnus of the varsity Columbia soccer program) spoke at the event, offering professional ...
Breaking Medicine News(10 mins):
(Date:2/4/2016)...  The Senior Care Pharmacy Coalition (SCPC) today ... Jason Chaffetz (R-UT) and Ranking Member ... , "Developments in the Prescription Drug Market," to ... about abusive pharmacy benefit manager (PBM) pricing practices. ... Member Elijah Cummings (D-MD) are diligent, serious lawmakers ...
(Date:2/4/2016)... , Feb. 4, 2016  Montoya Love is ... in the field of Pharmaceuticals. Montoya is the Regulatory ... Manufacturing and ... Becton Dickinson provides healthcare institutions, clinical laboratories ... throughout fifty countries across the globe. ...
(Date:2/4/2016)... Mettler-Toledo International Inc. (NYSE: MTD ) today announced ... highlights: , Sales in local currency increased ... Reported sales decreased 3% as currency reduced sales growth ... per diluted share as reported (EPS) were $4.44, compared ... was $4.65, an increase of 10% over the prior-year ...
Breaking Medicine Technology: