Navigation Links
$1 million from W.M. Keck Foundation spurs development of new generation 3-D 'Cell-CT' imaging

The W. M. Keck Foundation has awarded Arizona State University (ASU) a $1 million grant to the team of scientists led by Deirdre Meldrum, Ph.D., at the Biodesign Institute. The team is working to build a next-generation, three-dimensional (3D) imaging microscope, called a "Cell-CT" scanner, that will perform functional computed tomographic (CT) imaging of individual living cells. This groundbreaking technology will allow researchers to observe and assess the cellular function and disease status of living cells, enabling scientists to gain new insights into the metabolic pathways of disease, such as cancer.

This next-generation Cell-CT scanner offers a transformative view of the biological structural and functional inter-relationships at the single cell level. Leveraging leading-edge technology developed by VisionGate, Inc. (Phoenix, AZ, in collaboration with Meldrum's team, this project will advance applications in basic and clinical science, deepening scientific understanding of metabolism and disease processes, and expanding the horizons of medical diagnostics.

The Biodesign Institute at ASU is boldly pushing the frontiers of science and medicine to uncover transformative solutions to the most urgent and complex challenges in human health, national security, and the well-being of our planet. Driven by passion and collaborative synergy, scientific inquiry and technology research and development, and fusing biosciences, engineering, and advanced computing to fuel the translation of research advances into real solutionsBiodesign and Meldrum's Center for Biosignature Discovery Automation (CBDA) are finding the clues that will enable us to diagnose and treat cancer sooner, in more targeted ways.

In Computed Tomography (CT), multiple 2D images taken from many perspectives are analyzed computationally to create a 3D rendering of a living structure or tissue. In diagnostic radiology, x-ray CT takes hundreds of perspective views around a single axis to create a cross sectional view through the patient's anatomy. Similarly, the Cell-CT combines hundreds of submicron-resolution optical images taken while rotating a single cell to render a functional 3D image of the cell. That image reveals important metabolic and disease processes in action.

One of the biggest challenges in the Cell-CT scanner's development is finding the best way to rotate cells precisely without harming them. Initially, two methods will be explored: the first rotates cells in a microfluidic vortex, and the second rotates cells with an infrared light beam. The technology will be validated through comparison studies between Cell-CT scanned cells grown in culture that represent various stages of cancers, and cells taken from human biopsies spanning the same disease spectrum.

The four-year effort is led by Professor Meldrum, who is head of CBDA at the Biodesign Institute and a leader in microdevices for biological research. Also at CBDA are Roger Johnson, Ph.D., an expert in instrumentation and algorithms for 3D tomographic reconstruction, who will oversee project operations and lead algorithmic and image processing research. Laimonas Kelbauskas, Ph.D., a specialist in laser physics and complex optical system design,will lead the optical physics and engineering team to design and build the new-generation Cell-CT system for living cells. Joining Meldrum from Turku University in Finland is Lea Sistonen, Ph.D., a renowned expert in the effects of cell stress on signaling and gene expression. The strength of this project team is its combination of expertise and experience.

"We're tremendously excited by the potential this technology presents for important breakthroughs, not only in cellular biology but also in medicine and ultimately personalized health care," Meldrum said. The Cell-CT scanner may enable, for the first time, rapid 3D spatial localization of proteins, and assessment of their concentrations in subcellular compartments and microdomains, providing powerful insights concerning relationships between cell structure and function in disease.


Contact: Joe Caspermeyer
Arizona State University

Related medicine news :

1. $1 million USDA grant aims to reduce obesity in preschoolers
2. $7.9 million grant to improve food security, nutrition in Mozambique
3. McKesson Foundation awards $1.3 million in 6 Mobilizing for Health Research grants
4. $1.9 million NIH grant supports research in the most common soft tissue tumor in children
5. 3.1 Million Hispanic Americans Struggle With Arthritis
6. 4.7 million Californians to gain coverage under health reform, new study estimates
7. Fossil Suggests Humans Walked Upright 3 Million Years Ago
8. Johns Hopkins School of Medicine grants $5 million to study cognitive disorders
9. Apica Cardiovascular receives $5.1 million investment for improved heart surgery system
10. Researchers predict nearly 1.3 million cancer deaths in Europe in 2011
11. MDA awards $13.5 million in grants for research treatments for neuromuscular diseases
Post Your Comments:
Related Image:
$1 million from W.M. Keck Foundation spurs development of new generation 3-D 'Cell-CT' imaging
(Date:11/25/2015)... ... 25, 2015 , ... Additional breast cancers found with MRI ... to a study published online in the journal Radiology. Researchers said that in ... a change in treatment. , Breast MRI is the most sensitive technique for ...
(Date:11/25/2015)... ... November 25, 2015 , ... As part ... For Empowerment ™ attracts volunteers together who want to combine talents and resources ... key stakeholders in the process. The non-profit launched its first major fundraiser on ...
(Date:11/25/2015)... ... 2015 , ... The holiday season is jam-packed with family ... of attendees is of the utmost importance. Whether you are cooking at home ... recipes a try this holiday season. , Turkey Croquettes ,     Ingredients: ...
(Date:11/25/2015)... MN (PRWEB) , ... November 25, 2015 , ... Finnleo, ... through Christmas Eve on several models of traditional and far-infrared saunas. , ... Nordic Spruce is the most traditional Finnish sauna wood, and Finnleo uses only European ...
(Date:11/25/2015)... ... November 25, 2015 , ... Medical Solutions, one of the ... stellar workplace culture with the company’s Cincinnati office being named a finalist among ... was named a finalist in Cincinnati Business Courier’s 13th annual Greater Cincinnati Best ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... DUBLIN , Nov. 25, 2015 /PRNewswire/ ... announced the addition of the "Global ... to their offering. --> ... "Global Brain Monitoring Devices Market 2015-2019" ... Research and Markets ( ) ...
(Date:11/25/2015)... global healthcare industry is expected to grow at a rate ... has the highest projected growth at 12.7%, and ... is second with growth projected at 11.5%. ... 2013-2014, total government funded healthcare was nearly 68%. Federal government ... 2013-2014. In real terms, out of pocket expenditure increased by ...
(Date:11/25/2015)... , Nov. 25, 2015  Amgen (NASDAQ: ... License Application (BLA) with the United States ... ABP 501, a biosimilar candidate to Humira ® ... biosimilar application submitted to the FDA and represents Amgen,s ... Sean E. Harper , M.D., executive vice president ...
Breaking Medicine Technology: