Navigation Links
$1.9 million NIH grant supports research in the most common soft tissue tumor in children
Date:2/20/2011

A nearly $2 million grant from the National Institutes of Health (NIH) will help investigators at Nationwide Children's Hospital search for biomarkers that may be linked to the development and outcome of hemangiomas, the most common soft tissue tumor in children. Nationwide Children's is home to the only Hemangioma and Vascular Malformations Clinic in the United States with an NIH-sponsored clinical study.

A hemangioma is an abnormal buildup of blood vessels in the skin or internal organs. Hemangiomas appear as a red to reddish-purple, raised lesion or as a massive, raised tumor.

"Hemangiomas can be extremely disfiguring and life-threatening, resulting in significant distress for the families of affected children," said the grant's principal investigator, Gayle Gordillo, MD, director of the Hemangioma and Vascular Malformations Clinic in Plastic and Reconstructive Surgery at Nationwide Children's Hospital. "A critical barrier to improving the clinical outcomes for affected children is the lack of low-risk treatment options. The most effective treatment options all have life-threatening side effects."

Dr. Gordillo's laboratory research using a mouse-model has shown that the formation of these soft tissue tumors depends on nox-4. Nox-4 is an enzyme involved in the production of reactive oxygen species, a natural part of a healthy cellular environment. However, excessive production of reactive oxygen species can result in significant damage to the cell.

As part of the NIH-funded study, Dr. Gordillo and colleagues at both Nationwide Children's Hospital and The Ohio State University Medical Center, will examine urine and blood samples from patients with hemangioma beginning from the time they enroll in the study until they are 2 years of age. They will also perform ultrasound on each patient to measure the size of the hemangioma and velocity of the blood flowing to the tumor. Recruitment for study participants will take place at Nationwide Children's.

By comparing samples from these patients with samples from age-matched healthy children, Dr. Gordillo's team will be able to investigate how nox-4 regulates growth of endothelial cells that develop into tumors. They will also search to determine whether biological products caused by nox-4 function can be used as biomarkers to determine patient outcome.

"This is the first prospective, longitudinal study aimed at identifying biomarkers in children with hemangiomas," said Dr. Gordillo, also a faculty member at The Ohio State University College of Medicine. "Our goal is to further understand the role oxidant production has on hemangioma formation. Our findings could help identify potential new treatment targets and establish biomarkers that can be used to design clinical trials to test new therapeutics to treat these soft tissue tumors."


'/>"/>

Contact: Mary Ellen Peacock
MaryEllen.Peacock@NationwideChildrens.org
614-355-0495
Nationwide Children's Hospital
Source:Eurekalert

Related medicine news :

1. 3.1 Million Hispanic Americans Struggle With Arthritis
2. 4.7 million Californians to gain coverage under health reform, new study estimates
3. Fossil Suggests Humans Walked Upright 3 Million Years Ago
4. Johns Hopkins School of Medicine grants $5 million to study cognitive disorders
5. Apica Cardiovascular receives $5.1 million investment for improved heart surgery system
6. Researchers predict nearly 1.3 million cancer deaths in Europe in 2011
7. MDA awards $13.5 million in grants for research treatments for neuromuscular diseases
8. U-M Medical School researchers set new record in NIH funding: $368.7 million
9. UofL awarded $9.56 million to form first-ever multicenter cardiovascular research network
10. $2.8 million grant boosts cystic fibrosis research at Queens
11. Cedars-Sinai research team awarded $1.9 million from CIRM to develop new tools and technologies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/8/2016)... ... 2016 , ... The Compretta Insurance Agency, a family owned insurance and financial ... Hancock County area, is announcing the launch of a charity effort aimed at raising ... Food Pantry has worked for more than 30 years to meet the food needs ...
(Date:12/7/2016)... ... December 07, 2016 , ... DrugDev again demonstrated its ... is one of the early adopters completing EU-U.S. Privacy Shield Certification from the U.S. ... companies on both sides of the Atlantic with a mechanism to comply with EU ...
(Date:12/7/2016)... Kenosha, Wisconsin (PRWEB) , ... December 07, 2016 , ... ... the extraordinary new MedMaster™ MPCNGX . The MPCNGX is a multi-function, sealed, LED ... the right amount of light where and when it’s needed. , A ...
(Date:12/7/2016)... ... December 07, 2016 , ... Wavelink, an industry ... Control through a new partnership with Splashtop Inc. This remote control for Android ... to help businesses maximize their uptime and productivity. , Wavelink offers powerful enterprise ...
(Date:12/7/2016)... ... December 07, 2016 , ... In the early morning of October 30, ... medical call when he lost control of his patrol car. The vehicle overturned into ... he was transported to Atlanta Medical Center, where he later succumbed to his injuries. ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... , Dec. 8, 2016  EIP Pharma, LLC ... obtained proof-of-mechanism for neflamapimod (previously code named VX-745), ... 2a clinical trials that demonstrated significant Alzheimer,s disease ... (12-week treatment) and Study 303 (6-week treatment) are ... in Alzheimer,s Disease (CTAD) scientific conference in ...
(Date:12/8/2016)... 2016 Dignitana, a world leader in medical ... Technology, creator of the award-winning, patented Boa® system, to ... the DigniCap® scalp cooling system. DigniCap® was cleared by ... and is the first medical scalp cooling device to ... system features a patented tight-fitting silicone cooling cap that ...
(Date:12/8/2016)... SAN DIEGO , Dec. 8, 2016 /PRNewswire/ ... dedicated to improving cancer patient care from diagnosis ... the company,s recently completed Phase 1b study in ... at the San Antonio Breast Cancer Symposium. ... Cancer Center at UC San Diego Health, delivered ...
Breaking Medicine Technology: