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$1.4 million grant awarded to study 2 little-understood neurological disorders
Date:12/18/2007

NEW YORK (Dec. 17, 2007) -- The Leon Levy Foundation has awarded over $1.4 million in grants to NewYork-Presbyterian Hospital/Weill Cornell Medical Center in New York City in support of collaborative research into two little-understood neurological disorders: chemotherapy-related cognitive dysfunction in adult cancer patients and Normal Pressure Hydrocephalus (NPH), also known as "water on the brain," a progressive neurologic disorder in older adults that may be present in as many as 5 percent of dementia cases.

The three-year joint study on chemotherapy-related cognitive dysfunction will assess changes in brain structure, particularly in the hippocampus and the white matter, and cognitive functions in adult cancer patients treated with chemotherapy prior to receiving a stem-cell transplant.

"A significant number of cancer patients treated with chemotherapy experience changes in memory and other cognitive functions that interfere with their ability to lead a normal life. Yet despite the seriousness of the problem, little is known about it," says the study's principal investigator, Dr. Denise D. Correa, assistant professor of neuropsychology in Neurology at Weill Cornell Medical College and a neuropsychologist at NewYork-Presbyterian/Weill Cornell and at Memorial Sloan-Kettering Cancer Center.

The collaborative study involving researchers from Weill Cornell, Memorial Sloan-Kettering Cancer Center (MSKCC) and City University of New York (CUNY) will be the first to test the hypothesis that chemotherapy affects specific brain structures, particularly the hippocampus and white matter.

Dr. Correa hopes the research leads to efforts to identify "neuroprotective agents" that may minimize or prevent chemotherapy-related cognitive dysfunction.

A second three-year study will investigate techniques to improve detection of Normal Pressure Hydrocephalus (NPH), a condition in which an excess of fluid compresses the brain, causing d
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Contact: Andrew Klein
ank2017@med.cornell.edu
212-821-0560
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Source:Eurekalert

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