Navigation Links
$1.3M NIH grant to fund Parkinson's disease study
Date:5/28/2008

BINGHAMTON, NY -- A Binghamton University researcher will receive $1.33 million from the National Institutes of Health to support Parkinson's research that will focus not only on the treatment of the disease but also in the side effects of treatment.

"Parkinson's disease patients have trouble with movement," said Christopher Bishop, assistant professor of psychology. "They move more slowly. They have rigidity in their limbs. They have balance problems and tremors."

The cardinal symptoms are a result of a deficit of dopamine in the brain. Dopamine is a neurotransmitter that's essential for movement; it also plays an important role in behavior, cognition and sleep. In Parkinson's patients, neurons in the brain that make dopamine die. Scientists still aren't sure why; genetic factors are believed to play only a small role.

This deficit of dopamine can be reversed with treatment using a compound called L-DOPA, which has been the gold standard in Parkinson's treatment for about 50 years. The brain converts L-DOPA into dopamine, which is why it's an effective replacement therapy for patients. For five to 10 years, this treatment works well. "The problem," Bishop explained, "is that Parkinson's is a progressive disease. You lose more and more of these neurons as time goes on, so therapeutically, doses of L-DOPA must increase."

While that works for some people, many patients suffer troubling side effects as the dosage increases. "By year 10," Bishop said, "as many as 90 percent of patients will start to suffer from motor fluctuations and something called L-DOPA-induced dyskinesia. So you go from a state of no treatment where you're not moving well, to a state where the drug is working well and you're moving fluidly, to a point where L-DOPA doses are very high and you're producing these abnormal, involuntary movements."

The excessive movements patients display aren't a result of the Parkinson's disease, but rather a symptom of the chronic L-DOPA. And patients can't simply stop taking L-DOPA; if they do, they face a nearly "frozen" life with incredibly limited ability to move.

Bishop and his colleagues at Wayne State University's medical school and the Veterans Administration hospital in Chicago hope to find a way to reduce dyskinesia and suppress these movements. There are very few treatments available, in part because how dyskinesia develops is still a mystery.

"We are beginning to believe that dyskinesia is actually the inability to suppress motor memories as a result of the drug's stimulation," Bishop said.

One possible treatment relates to glutamate, a neurotransmitter in the brain that can play a role in these memory processes, helping to lay down new pathways for motor memories. The five-year grant from the National Institute for Neurological Disorders and Stroke will allow Bishop and his team to study serotonin compounds that reduce glutamate following L-DOPA treatment. Bishop's work has also been supported by the American Parkinson's Disease Association.

According to Bishop, Parkinson's is an increasingly urgent medical concern. Roughly 1 million people in the United States have Parkinson's; 50,000 more Americans are diagnosed with the disease each year.

"That's only going to increase as our population ages," Bishop said. "This is not something that's going away.


'/>"/>

Contact: Gail Glover
gglover@binghamton.edu
607-777-2174
Binghamton University
Source:Eurekalert  

Related medicine news :

1. Cornell receives federal grants to create fabrics to render toxic chemicals harmless
2. Video/Online Games for Health: 12 Research Teams From Across U.S. To Receive Major Grants
3. ClearWay Minnesota(SM) Board Approves $1.4 Million in New Grants to Reduce Tobaccos Harm
4. Five Heart Heroines Honored With Cheerios Sisters Saving Hearts(TM) Grants
5. Research Grant to Fund Free Surgeries for Women Suffering From Blocked Fallopian Tubes
6. Forty-Two Free Clinics Across State Share $1 Million in Grants From Blue Cross Blue Shield of Michigan
7. Healthy Farms, Healthy Schools Grant Applications Available
8. International Diabetes Federation gives grant to diabetes screening & prevention program in Vietnam
9. Kresge Foundation Employs New Funding Methods in its First Quarter Grant Awards of Nearly $43 Million
10. International Diabetes Federation gives grant to metabolic syndrome research project in Australia
11. Video: Pediatric Brain Tumor Foundation Gives $6 Million Grant to Duke
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
$1.3M NIH grant to fund Parkinson's disease study
(Date:2/21/2017)... ... ... Along with Valentine’s Day, February marks American Heart Month, a great time to ... lifetime of heart health. In addition, it is a time to prepare your ... Society of New Jersey (ATSNJ) is urging sports programs to prepare comprehensive guidelines for ...
(Date:2/20/2017)... Wis. (PRWEB) , ... February 21, 2017 , ... ... guidebook offering readers a way to “ Getting Over the Bump in the Road ... tips and lessons learned on how to cope with the ups and downs experienced ...
(Date:2/20/2017)... ... February 20, 2017 , ... Scrubbing in for his ... Houston, Dr. Christopher Pezzi remembers the excitement of the surgeon training him. , “He ... us to do this? Don’t tell anyone, but I would do it for free,’” ...
(Date:2/20/2017)... ... February 20, 2017 , ... ... a cloud-based self-service technology that runs on the Posiflex XT-series of touch screen ... during HIMSS17 in Orlando, Florida. The terminal provider Posiflex is helping ...
(Date:2/20/2017)... ... February 20, 2017 , ... ... you to stop by for a visit this week at HIMSS 2017 Conference ... executives from around the globe. Sensogram will be featured in the conference’s Connected ...
Breaking Medicine News(10 mins):
(Date:2/21/2017)... IBM ) Research has today announced new research developments ... retina. The Melbourne based IBM researchers ... in retina images, which could in the future offer doctors ... who may be at risk of eye diseases – such ... world. The research began in 2015 and ...
(Date:2/21/2017)... , Feb. 21, 2017 Diabetic Shoes Market: Overview ... ... be described as a disease, which is marked by high ... and insulin action. The disease has become a global epidemic ... Diabetes affects several organs of the body including eyes, kidneys, ...
(Date:2/21/2017)... -- /PR Newswire/ -- UBM Medica,s Eye Care Group ( ... Modern Retina ( www.modernretina.com ), a new ... Built upon the success of Ophthalmology Times , ... in the areas of retinal surgery, clinical information, research, ... informational needs and filling existing educational gaps, Modern ...
Breaking Medicine Technology: