Navigation Links
$1.3M NIH grant to fund Parkinson's disease study
Date:5/28/2008

BINGHAMTON, NY -- A Binghamton University researcher will receive $1.33 million from the National Institutes of Health to support Parkinson's research that will focus not only on the treatment of the disease but also in the side effects of treatment.

"Parkinson's disease patients have trouble with movement," said Christopher Bishop, assistant professor of psychology. "They move more slowly. They have rigidity in their limbs. They have balance problems and tremors."

The cardinal symptoms are a result of a deficit of dopamine in the brain. Dopamine is a neurotransmitter that's essential for movement; it also plays an important role in behavior, cognition and sleep. In Parkinson's patients, neurons in the brain that make dopamine die. Scientists still aren't sure why; genetic factors are believed to play only a small role.

This deficit of dopamine can be reversed with treatment using a compound called L-DOPA, which has been the gold standard in Parkinson's treatment for about 50 years. The brain converts L-DOPA into dopamine, which is why it's an effective replacement therapy for patients. For five to 10 years, this treatment works well. "The problem," Bishop explained, "is that Parkinson's is a progressive disease. You lose more and more of these neurons as time goes on, so therapeutically, doses of L-DOPA must increase."

While that works for some people, many patients suffer troubling side effects as the dosage increases. "By year 10," Bishop said, "as many as 90 percent of patients will start to suffer from motor fluctuations and something called L-DOPA-induced dyskinesia. So you go from a state of no treatment where you're not moving well, to a state where the drug is working well and you're moving fluidly, to a point where L-DOPA doses are very high and you're producing these abnormal, involuntary movements."

The excessive movements patients display aren't a result of the Parkinson's disease, but rather a symptom of the chronic L-DOPA. And patients can't simply stop taking L-DOPA; if they do, they face a nearly "frozen" life with incredibly limited ability to move.

Bishop and his colleagues at Wayne State University's medical school and the Veterans Administration hospital in Chicago hope to find a way to reduce dyskinesia and suppress these movements. There are very few treatments available, in part because how dyskinesia develops is still a mystery.

"We are beginning to believe that dyskinesia is actually the inability to suppress motor memories as a result of the drug's stimulation," Bishop said.

One possible treatment relates to glutamate, a neurotransmitter in the brain that can play a role in these memory processes, helping to lay down new pathways for motor memories. The five-year grant from the National Institute for Neurological Disorders and Stroke will allow Bishop and his team to study serotonin compounds that reduce glutamate following L-DOPA treatment. Bishop's work has also been supported by the American Parkinson's Disease Association.

According to Bishop, Parkinson's is an increasingly urgent medical concern. Roughly 1 million people in the United States have Parkinson's; 50,000 more Americans are diagnosed with the disease each year.

"That's only going to increase as our population ages," Bishop said. "This is not something that's going away.


'/>"/>

Contact: Gail Glover
gglover@binghamton.edu
607-777-2174
Binghamton University
Source:Eurekalert  

Related medicine news :

1. Cornell receives federal grants to create fabrics to render toxic chemicals harmless
2. Video/Online Games for Health: 12 Research Teams From Across U.S. To Receive Major Grants
3. ClearWay Minnesota(SM) Board Approves $1.4 Million in New Grants to Reduce Tobaccos Harm
4. Five Heart Heroines Honored With Cheerios Sisters Saving Hearts(TM) Grants
5. Research Grant to Fund Free Surgeries for Women Suffering From Blocked Fallopian Tubes
6. Forty-Two Free Clinics Across State Share $1 Million in Grants From Blue Cross Blue Shield of Michigan
7. Healthy Farms, Healthy Schools Grant Applications Available
8. International Diabetes Federation gives grant to diabetes screening & prevention program in Vietnam
9. Kresge Foundation Employs New Funding Methods in its First Quarter Grant Awards of Nearly $43 Million
10. International Diabetes Federation gives grant to metabolic syndrome research project in Australia
11. Video: Pediatric Brain Tumor Foundation Gives $6 Million Grant to Duke
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
$1.3M NIH grant to fund Parkinson's disease study
(Date:2/5/2016)... ... February 05, 2016 , ... Give To Cure today announced that ... donate to Give To Cure’s campaign that is crowdfunding clinical trials to help find ... share payments through a smart device. In 2015 alone, Venmo processed $7.5 billion in ...
(Date:2/5/2016)... ... , ... At its annual meeting held last week, the American Parkinson Disease ... of Directors. Mr. McDermott succeeds former APDA Chairman, Fred Greene. , "We are pleased ... APDA President and CEO. “Pat has tirelessly served APDA since 2001 when he was ...
(Date:2/5/2016)... ... February 05, 2016 , ... ... CitiDent, announces that it is now welcoming orthodontist, Dr. Amanda Cheng, to ... a complete range of oral health care, including general dentistry, cosmetic treatments, periodontics, ...
(Date:2/5/2016)... ... February 05, 2016 , ... Health and wellness is a topic ... in the event they are experiencing an illness. Migraines are a severe form of ... afflicted with migraines would not wish the pain on their worst enemy, the feeling ...
(Date:2/5/2016)... ... , ... Calls Blacklist has just been updated by mobile app developer Vlad ... has fixed known bugs within the app. Calls Blacklist allows its users to only ... any of their device’s battery power or memory. It provides a powerful call blocker ...
Breaking Medicine News(10 mins):
(Date:2/4/2016)... Calif. , Feb. 4, 2016  Edwards Lifesciences ... patient-focused innovations for structural heart disease and critical care ... accelerated share repurchase (ASR) agreement with Morgan Stanley & ... stock.  This repurchase is part of the Company,s previously ... the Company,s common stock.  --> ...
(Date:2/4/2016)... 2016   Bernstein Liebhard LLP today announced that ... States District Court for the District of Arizona ... of all persons or entities who purchased common shares of ... ) from March 3, 2015 through January 25, 2016 (the ... officers with violations of the Securities Exchange Act of 1934.  ...
(Date:2/4/2016)... LODI, N.J. , Feb. 4, 2016  Montoya ... Pinnacle Professional in the field of Pharmaceuticals. Montoya is ... . ... and supplies, Becton Dickinson provides healthcare institutions, ... medical equipment throughout fifty countries across the globe. ...
Breaking Medicine Technology: