Sickle cell trait

Sickle cell trait - The child is carrying the defective gene, HbS, but also has some normal hemoglobin, HbA. This is referred to as HbAS. Children with sickle cell trait are usually without symptoms of the disease. Mild anemia may occur.
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About 8% of African Americans have sickle cell trait; that is, they are heterozygotes, usually symptomless carriers who have inherited a normal hemoglobin gene from one parent and hemoglobin-S from the other.
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One abnormal gene causes a condition called sickle cell trait. This occurs in eight to 10 percent of African Americans and is only rarely associated with health complaints.
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People with sickle cell trait usually have no symptoms of sickle cell anemia, but they can pass the gene for sickle cell hemoglobin to their children.
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Sickle cell trait is a mendelian trait. It refers to the situation in which a person has one copy (and one copy only) of the gene for sickle cell but does not have sickle cell disease (which requires two copies of the sickle cell gene).
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Sickle cell anemia can only result when two carriers with sickle cell trait have a child together. Therefore, genetic counseling is recommended for all carriers of sickle cell trait (about 1 in 12 African Americans has sickle cell trait).
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To determine if a person has sickle cell anemia or sickle cell trait, physicians may order a number of blood tests (e.g., hemoglobin electrophoresis, sickle cell test). Newborns are routinely screened for the abnormal gene in many states.
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Because sickle cell anemia is inherited, it can be prevented if couples who both carry the sickle cell trait gene do not have children.
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Those who have one HbA gene and one HbS gene are said to have sickle cell trait. They are carriers of sickle cell anaemia and are only at risk of problems under extreme conditions, such as during major surgery.
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Serum Sickness
Sickle Cell Trait (Sickle Cell Anemia)
Sickle Cell Anemia
Thalassemia
Thalassemia Major (Thalassemia)
Thalassemia Minor (Thalassemia)
Thromboembolic State (Thromboembolism)
Thromboembolism ...
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