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Proteus Syndrome


Proteus syndrome: A disturbance of cell growth including benign tumors under the skin, overgrowth of the body, often more on one side than the other (hemihypertrophy), and overgrowth of fingers (macrodactyly).
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Examples of overgrowth syndromes include neurofibromatosis, Sotos syndrome, Beckwith-Wiedemann syndrome, Simpson-Golabi-Behmel syndrome, Weaver syndrome, Proteus syndrome, Sturge-Weber syndrome, and fragile X syndrome.
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Both present as an overgrowth of soft tissue and bone, usually in a limb. For many of the very rare combined forms, e.g. Maffucci, Bannayan-Riley-Ruvalcaba, or Proteus syndrome, the vascular anomaly may be a minor component.
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