Alpha-1 Antitrypsin Deficiency

Alpha-1 antitrypsin deficiency
Definition:
Alpha-1 antitrypsin deficiency is a lack of a liver protein that blocks the destructive effects of certain enzymes. The condition may lead to emphysema and liver disease.
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Alpha-1 antitrypsin deficiency (AATD) is a lack of alpha-1 antitrypsin, a protein made by the liver that is released into the bloodstream. AATD is a genetic disease that can affect the liver or lung.
What causes AATD?
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Alpha-1 antitrypsin deficiency results from a genetic defect. The mechanism that causes associated liver disease and emphysema in some people with this deficiency is not known, however some evidence suggests that it may be related to inflammation.
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Alpha-1 Antitrypsin Deficiency - Source:MedicineNet
Chronic Obstructive Pulmonary Disease - Learn about COPD - Chronic Obstructive Pulmonary Disease which is primarily two related diseases - chronic bronchitis and emphysema. Source:MedicineNet ...
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An inherited disorder (passed down from parents) called alpha-1 antitrypsin deficiency, or AAT deficiency, can also cause emphysema. If you are a smoker AND have this genetic disorder, the lungs become damaged more quickly.
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American Thoracic Society/European Respiratory Society (2003). ATS/ERS: Standards for the diagnosis and management of individuals with alpha-1 antitrypsin deficiency. American Journal of Respiratory and Critical Care Medicine, 168(7): 820"822.
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These include diseases that cause excess copper or iron to be deposited in the liver as well as alpha-1 antitrypsin deficiency — ...
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